scholarly journals Double-Blind, Multicenter, Active-Controlled, Randomized Clinical Trial to Assess the Safety and Efficacy of Orally Administered Nicorandil in Patients With Stable Angina Pectoris in China

2007 ◽  
Vol 71 (6) ◽  
pp. 826-833 ◽  
Author(s):  
Wen-Ling Zhu ◽  
Yuan-Dong Shan ◽  
Jing-Xuan Guo ◽  
Jia-Ping Wei ◽  
Xin-Chun Yang ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Angina Pectoris ◽  
Randomized Clinical Trial ◽  
Stable Angina ◽  
Stable Angina Pectoris ◽  
Double Blind ◽  
Safety And Efficacy

scholarly journals Efficacy and safety of oral Guanxinshutong capsules in patients with stable angina pectoris in China: a prospective, multicenter, double-blind, placebo-controlled, randomized clinical trial

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yang Li ◽  
Lei Zhang ◽  
Shuzheng Lv ◽  
Xiaozeng Wang ◽  
Jian Zhang ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Placebo Group ◽  
Angina Pectoris ◽  
Randomized Clinical Trial ◽  
Stable Angina ◽  
Efficacy And Safety ◽  
Stable Angina Pectoris ◽  
Double Blind ◽  
Double Blind Placebo ◽  
St Segment

Abstract Background To assess the efficacy and safety of oral Guanxinshutong (GXST) capsules in Chinese patients with stable angina pectoris (SAP) in a prospective, multicenter, double-Blind, placebo-controlled, randomized clinical trial (clinicaltrials.gov Identifier: NCT02280850). Methods Eligible patients were randomized 1:1 to the GXST or placebo group. Current standard antianginal treatment except for nitrate drugs was continued in both groups, who received an additional 4-week treatment of GXST capsule or placebo. Primary endpoint was the change from baseline in angina attack frequency after the 4-week treatment. Secondary endpoints included the reduction of nitroglycerin dose, score of Seatntle Agina Questionnaire, exercise tolerance test defined as time to onset of chest pain and ST-segment depression at least 1 mm greater than the resting one. Results A total of 300 SAP patients from 12 centers in China were enrolled between January 2013 and October 2015, and they were randomly divided into the GXST group and the placebo group (150 patients in each group). Of whom, 287 patients completed the study (143 patients in the GXST group, 144 patients in the placebo group). The baseline characteristics of the two groups were comparable. After 4-week treatment with GXST capsules, the number of angina attacks and the consumption of short-acting nitrates were significantly reduced. In addition, the quality of life of patients were also substantially improved in the GXST group. No significant differences in the time of onset of angina and 1-mm ST segment depression were noted between the two groups. 7 patients (4.1%) in the GXST group and 3 patients (2.1%) in the placebo group reported at least one adverse event, respectively. Conclusions GXST capsules are beneficial for the treatment of SAP patients.

Comparison of safety and efficacy of carvedilol and metoprolol in stable angina pectoris

1999 ◽  
Vol 83 (5) ◽  
pp. 643-649 ◽  
Author(s):  
Reinhard van der Does ◽  
Ulrike Hauf-Zachariou ◽  
Egon Pfarr ◽  
Werner Holtbrügge ◽  
Steffen König ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Stable Angina Pectoris ◽  
Safety And Efficacy
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