scholarly journals Combined Treatment of Sustained-Release Basic Fibroblast Growth Factor and Sarpogrelate Enhances Collateral Blood Flow Effectively in Rabbit Hindlimb Ischemia

2006 ◽  
Vol 70 (9) ◽  
pp. 1190-1194 ◽  
Author(s):  
Keiichi Hirose ◽  
Masatoshi Fujita ◽  
Akira Marui ◽  
Yoshio Arai ◽  
Hisashi Sakaguchi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Growth Factor ◽  
Sustained Release ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Combined Treatment ◽  
Fibroblast Growth ◽  
Collateral Blood Flow ◽  
Hindlimb Ischemia

Basic fibroblast growth factor enhances myocardial collateral flow in a canine model

1994 ◽  
Vol 266 (4) ◽  
pp. H1588-H1595 ◽  
Author(s):  
E. F. Unger ◽  
S. Banai ◽  
M. Shou ◽  
D. F. Lazarous ◽  
M. T. Jaklitsch ◽  
...  
Keyword(s):  
Blood Flow ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Numerical Density ◽  
Collateral Flow ◽  
Fibroblast Growth ◽  
Collateral Blood Flow ◽  
Basic Fgf ◽  
And Control

Basic fibroblast growth factor (FGF) is a multifunctional peptide that may play an integral role in angiogenesis associated with coronary collateral formation and myocardial infarct healing. We sought to determine the effects of exogenously administered basic FGF on collateral blood flow to ischemic myocardium. Ameroid constrictors were used to cause gradual occlusion of the left circumflex coronary artery in dogs. Basic FGF (110 micrograms, n = 9) or saline (n = 12) was given as a daily bolus injection directly into the collateral-dependent zone, beginning 10 days after placement of the Ameroid and continuing for 28 days. Collateral flow was assessed weekly as the ratio of collateral to normal zone (CZ/NZ) blood flow during maximal pharmacologically induced coronary vasodilation. The CZ/NZ increased in both treated and control dogs as a function of time; however, transmural collateral flow in basic FGF-treated dogs significantly exceeded that of control dogs by the second week of treatment. Final CZ/NZ blood flow ratios were 0.49 +/- 0.05 and 0.35 +/- 0.02 in the treated and control groups, respectively (means +/- SE, P = 0.0002). Treatment with basic FGF was also associated with significant increases in the numerical density of distribution vessels and endothelial cell DNA synthesis within the CZ. We also found that basic FGF had acute effects as a coronary vasodilator. Thus exogenous administration of basic FGF enhances maximal collateral blood flow in dogs with myocardial ischemia secondary to single-vessel coronary occlusion, an effect that is likely mediated through the direct angiogenic effects of the peptide, although its acute vasodilatory effects may also play a role.

Exercise training enhances basic fibroblast growth factor-induced collateral blood flow

1998 ◽  
Vol 274 (6) ◽  
pp. H2053-H2061 ◽  
Author(s):  
H. T. Yang ◽  
Robert W. Ogilvie ◽  
Ronald L. Terjung
Keyword(s):  
Blood Flow ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Calf Muscle ◽  
Muscle Performance ◽  
Fibroblast Growth ◽  
Collateral Blood Flow ◽  
Collateral Vessel ◽  
Blood Flows

This study evaluated whether daily exercise would enhance the peripheral collateral vessel development found in response to exogenous basic fibroblast growth factor (bFGF) infusion. After bilateral femoral occlusion, male Sprague-Dawley rats (∼325 g) received intra-arterial infusions of either bFGF (1 μg/day; n = 15) or carrier solution ( n = 13) via osmotic pumps for 2 wk. Subgroups of each treatment were kept sedentary (cage activity) or trained by walking at 20 m/min at 15% grade, two times a day, 5 days/wk for 4 wk. Training markedly increased citrate synthase activity in the active muscle ( P < 0.001). Muscle function and blood flows (85Sr microsphere) were evaluated using an isolated hindquarter perfused at 100 mmHg via the abdominal aorta. The significant increase in blood flow to the entire hindlimb in the sedentary animals, caused by bFGF infusion ( P < 0.05), was further increased ( P < 0.01) in the bFGF-trained group. The quantitatively largest increases in blood flows were observed in the collateral-dependent tissues of the distal hindlimb. Blood flows to the entire calf muscle group increased ∼140% in carrier-trained ( P < 0.001), ∼180% in bFGF sedentary ( P< 0.001), and ∼240% in the bFGF-trained ( P < 0.001) groups compared with the carrier sedentary group. The increases in collateral blood flow were functionally important, as improvements in calf muscle performance correlated with measured blood flows. Our results demonstrate that exogenous bFGF administration in combination with a moderate-intensity exercise program greatly increases collateral-dependent blood flow and improves muscle performance. That physical activity enriched the bFGF response is consistent with the hypothesis that hemodynamic factors are important contributors to collateral vessel enlargement.

scholarly journals Two intracoronary doses of basic fibroblast growth factor enhance collateral blood flow in dogs

1996 ◽  
Vol 27 (2) ◽  
pp. 36 ◽  
Author(s):  
Shamini Rajanayagam ◽  
Matie Shou ◽  
Venugopal Thirumurti ◽  
Everett Hodge ◽  
Daisy F. Lazarous ◽  
...  
Keyword(s):  
Blood Flow ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Collateral Blood Flow
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