scholarly journals Assessment of Myocardial Perfusion and Fatty Acid Metabolism in a Patient With Churg-Strauss Syndrome Associated With Eosinophilic Heart Disease

2004 ◽  
Vol 68 (6) ◽  
pp. 595-598 ◽  
Author(s):  
Nobuaki Shikama ◽  
Tomoo Nakagawa ◽  
Yasuo Takiguchi ◽  
Nobuyuki Aotsuka ◽  
Yoichi Kuwabara ◽  
...  
Keyword(s):  
Heart Disease ◽  
Fatty Acid ◽  
Myocardial Perfusion ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Churg Strauss Syndrome ◽  
Strauss Syndrome ◽  
Churg Strauss

First-pass myocardial perfusion abnormalities in Churg-Strauss Syndrome with cardiac involvement

2009 ◽  
Vol 25 (5) ◽  
pp. 501-510 ◽  
Author(s):  
Andreas Hansch ◽  
Alexander Pfeil ◽  
Reinhard Rzanny ◽  
Thomas Neumann ◽  
Werner A. Kaiser
Keyword(s):  
Myocardial Perfusion ◽  
Cardiac Involvement ◽  
Churg Strauss Syndrome ◽  
First Pass ◽  
Strauss Syndrome ◽  
Churg Strauss

scholarly journals Serial Alterations and Prognostic Implications of Myocardial Perfusion and Fatty Acid Metabolism in Patients With Acute Myocardial Infarction

2006 ◽  
Vol 70 (11) ◽  
pp. 1466-1474 ◽  
Author(s):  
Akiyoshi Hashimoto ◽  
Tomoaki Nakata ◽  
Nagara Tamaki ◽  
Takeshi Kobayashi ◽  
Takayuki Matsuki ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acid ◽  
Myocardial Perfusion ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Prognostic Implications

Myocardial Fatty Acid Metabolism in Health and Disease

2010 ◽  
Vol 90 (1) ◽  
pp. 207-258 ◽  
Author(s):  
Gary D. Lopaschuk ◽  
John R. Ussher ◽  
Clifford D. L. Folmes ◽  
Jagdip S. Jaswal ◽  
William C. Stanley
Keyword(s):  
Fatty Acids ◽  
Heart Disease ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Contractile Activity ◽  
Myocardial Fatty Acid ◽  
Cardiac Pathology ◽  
Energy Demands ◽  
Obesity And Diabetes

There is a constant high demand for energy to sustain the continuous contractile activity of the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of fatty acid β-oxidation is complex and is aimed at ensuring that the supply and oxidation of the fatty acids is sufficient to meet the energy demands of the heart. The metabolism of fatty acids via β-oxidation is not regulated in isolation; rather, it occurs in response to alterations in contractile work, the presence of competing substrates (i.e., glucose, lactate, ketones, amino acids), changes in hormonal milieu, and limitations in oxygen supply. Alterations in fatty acid metabolism can contribute to cardiac pathology. For instance, the excessive uptake and β-oxidation of fatty acids in obesity and diabetes can compromise cardiac function. Furthermore, alterations in fatty acid β-oxidation both during and after ischemia and in the failing heart can also contribute to cardiac pathology. This paper reviews the regulation of myocardial fatty acid β-oxidation and how alterations in fatty acid β-oxidation can contribute to heart disease. The implications of inhibiting fatty acid β-oxidation as a potential novel therapeutic approach for the treatment of various forms of heart disease are also discussed.

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