scholarly journals Past History of Obesity (Overweight by WHO Criteria) Is Associated With an Increased Risk of Nonfatal Acute Myocardial Infarction

2004 ◽  
Vol 68 (1) ◽  
pp. 41-46 ◽  
Author(s):  
Masakazu Washio ◽  
Ryoko Hayashi ◽  
the Fukuoka Heart Study Group
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Past History ◽  
Who Criteria ◽  
Increased Risk ◽  
History Of ◽  
History Of Obesity

scholarly journals Clinical cases of myocardial infarction in pregnant women: the role of hereditary thrombophilia

2020 ◽  
Vol 48 (5) ◽  
pp. 341-347
Author(s):  
S. R. Mravyan ◽  
T. S. Kovalenko ◽  
I. O. Shuginin ◽  
T. S. Budykina ◽  
S. I. Fedorova
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Pregnant Women ◽  
Myocardial Injury ◽  
Past History ◽  
False Negative ◽  
Hereditary Thrombophilia ◽  
History Of ◽  
Pai 1 ◽  
Clinical Cases

Acute myocardial infarction during pregnancy is a threatening complication with high maternal and perinatal mortality. According to the literature, hereditary thrombophilia is commonly associated with obstetric disorders and susceptibility to venous thrombosis, whereas arterial part of the vasculature, including coronary, is rarely involved. The article describes two clinical cases of pregnant women with acute myocardial infarction and post-infarction cardiosclerosis, in whom hereditary thrombophilia, associated with the gene PAI-1-675 polymorphism, was diagnosed. Mothers of both patients had suffered myocardial infarction at a young age, while past history of only one pregnant woman was remarkable for multiple perinatal losses. Myocardial infarction may manifest with intense headache mirroring systemic angiospasm.Based on the clinical observations of acute myocardial infarction in pregnancy, one could conclude that measurements of troponin levels that might be false negative should be done repeatedly, while the signs of transmural myocardial injury at ECG can evolve into those of an intramural myocardial infarction. Miscarriage and fetoplacental insufficiency have been found in the patients with combination of hereditary thrombophilia and myocardial injury. Coronary artery damage in pregnant women can be the result of hereditary thrombophilia, most often associated with the PAI-1-675 gene polymorphism, as well as its combination with the heterozygous state of other genes.The absence of past perinatal losses and venous thromboembolism in pregnant women with myocardial infarction does not exclude hereditary thrombophilia, and additional work-up of the patient and the proband family is mandatory to exclude the underlying pathology. The course of myocardial infarction may not require an intracoronary intervention, and treatment may consist of non-fractionated or low molecular weight heparin and calcium antagonists.

scholarly journals Risk of ischemic stroke in patients with acute myocardial infarction and new atrial fibrillation: a nationwide analysis

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
L Fauchier ◽  
A Bisson ◽  
A Bodin ◽  
J Herbert ◽  
T Genet ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Atrial Fibrillation ◽  
Acute Myocardial Infarction ◽  
Ischemic Stroke ◽  
Hazard Ratio ◽  
Adjusted Hazard Ratio ◽  
Risk Of Death ◽  
Increased Risk ◽  
History Of

Abstract Background In patients with acute myocardial infarction (AMI), history of atrial fibrillation (AF) and new onset AF during the early phase may be associated with a worse prognosis. Whether both conditions are associated with a similar risk of stroke and should be similarly managed is a matter of debate. Methods Based on the administrative hospital-discharge database, we collected information for all patients treated with AMI between 2010 and 2019 in France. The adverse outcomes were investigated during follow-up. Results Among 797,212 patients with STEMI or NSTEMI, 146,922 (18.4%) had history of AF, and 11,824 (1.5%) had new AF diagnosed between day 1 and day 30 after AMI. Patients with new AF were older and had more comorbidities than those with no AF but were younger and had less comorbidities than those with history of AF. Both groups with history of AF or new AF had less frequent STEMI and anterior MI, less frequent use of percutaneous coronary intervention but more frequent HF at the acute phase than patients with no AF. During follow-up (mean [SD] 1.8 [2.4] years, median [interquartile range] 0.7 [0.1–3.1] years), 163,845 deaths and 20,168 ischemic strokes were recorded. Using Cox multivariable analysis, compared to patients with no AF, history of AF was associated with a higher risk of death during follow-up (adjusted hazard ratio HR 1.06 95% CI 1.05–1.08) while this was not the case for patients with new AF (adjusted HR 0.98 95% CI 0.95–1.02). By contrast, both history of AF and new AF were associated with a higher risk of ischemic stroke during follow-up compared to patients with no AF: adjusted hazard ratio HR 1.29 95% CI 1.25–1.34 for history of AF, adjusted HR 1.72 95% CI 1.59–1.85 for new AF. New AF was associated with a higher risk of ischemic stroke than history of AF (adjusted HR 1.38 95% CI 1.27–1.49). Conclusion In a large and systematic nationwide analysis, AF first recorded in the first 30 days after AMI was associated with an increased risk of ischemic stroke. Specific management should be considered in order to improve outcomes in these patients after AMI. Funding Acknowledgement Type of funding source: None

scholarly journals Particulate Air Pollution and Risk of Cardiovascular Events Among Adults With a History of Stroke or Acute Myocardial Infarction

2021 ◽  
Author(s):  
Noelle S. Liao ◽  
Stephen Sidney ◽  
Kamala Deosaransingh ◽  
Stephen K. Van Den Eeden ◽  
Joel Schwartz ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiovascular Mortality ◽  
State Regulation ◽  
Susceptible Population ◽  
Increased Risk ◽  
Address Data ◽  
History Of ◽  
Increase In Risk ◽  
Cvd Mortality

Background Previous studies have found associations between fine particulate matter <2.5 µm in diameter (PM 2.5 ) and increased risk of cardiovascular disease (CVD) among populations with no CVD history. Less is understood about susceptibility of adults with a history of CVD and subsequent PM 2.5 ‐related CVD events and whether current regulation levels for PM 2.5 are protective for this population. Methods and Results This retrospective cohort study included 96 582 Kaiser Permanente Northern California adults with a history of stroke or acute myocardial infarction. Outcome, covariate, and address data obtained from electronic health records were linked to time‐varying 1‐year mean PM 2.5 exposure estimates based on residential locations. Cox proportional hazard models estimated risks of stroke, acute myocardial infarction, and cardiovascular mortality associated with PM 2.5 exposure, adjusting for multiple covariates. Secondary analyses estimated risks below federal and state regulation levels (12 µg/m 3 for 1‐year mean PM 2.5 ). A 10‐µg/m 3 increase in 1‐year mean PM 2.5 exposure was associated with an increase in risk of cardiovascular mortality (hazard ratio [HR], 1.20; 95% CI, 1.11–1.30), but no increase in risk of stroke or acute myocardial infarction. Analyses of <12 µg/m 3 showed increased risk for CVD mortality (HR, 2.31; 95% CI, 1.96–2.71), stroke (HR, 1.41; 95% CI, 1.09–1.83]), and acute myocardial infarction (HR, 1.51; 95% CI, 1.21–1.89) per 10‐µg/m 3 increase in 1‐year mean PM 2.5 . Conclusions Adults with a history of CVD are susceptible to the effects of PM 2.5 exposure, particularly on CVD mortality. Increased risks observed at exposure levels <12 µg/m 3 highlight that current PM 2.5 regulation levels may not be protective for this susceptible population.

scholarly journals APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease

Cholesterol ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Ikuko Kato ◽  
Susan Land ◽  
Jill Barnholtz-Sloan ◽  
Richard K. Severson
Keyword(s):  
Myocardial Infarction ◽  
Lipid Metabolism ◽  
Odds Ratio ◽  
Genetic Factors ◽  
Past History ◽  
Gallbladder Disease ◽  
Gallstone Disease ◽  
Functional Polymorphisms ◽  
Increased Risk ◽  
History Of

Dysfunctional lipid metabolism plays a central role in pathogenesis of major chronic diseases, and genetic factors are important determinants of individual lipid profiles. We analyzed the associations of two well-established functional polymorphisms (FABP2 A54T and APOE isoforms) with past and family histories of 1492 population samples. FABP2-T54 allele was associated with an increased risk of past history of myocardial infarction (odds ratio (OR) = 1.51). Likewise, the subjects with APOE4, compared with E2 and E3, had a significantly increased risk of past history myocardial infarction (OR = 1.89). The OR associated with APOE4 was specifically increased in women for past history of myocardial infarction but decreased for gallstone disease. Interactions between gender and APOE isoforms were also significant or marginally significant for these two conditions. FABP2-T54 allele may be a potential genetic marker for myocardial infarction, and APOE4 may exert sex-dependent effects on myocardial infarction and gallbladder disease.

Incidence and mortality of myocardial infarction among Catalonian older adults with and without underlying risk conditions: The CAPAMIS study

2018 ◽  
Vol 25 (17) ◽  
pp. 1822-1830 ◽  
Author(s):  
M José Forcadell ◽  
Angel Vila-Córcoles ◽  
Cinta de Diego ◽  
Olga Ochoa-Gondar ◽  
Eva Satué
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Atrial Fibrillation ◽  
Acute Myocardial Infarction ◽  
Population Based ◽  
Chronic Heart Disease ◽  
Increased Risk ◽  
Incidence And Mortality ◽  
History Of ◽  
Artery Disease

Background Population-based data about the epidemiology of acute myocardial infarction is limited. This study investigated incidence and mortality of acute myocardial infarction in older adults with specific underlying chronic conditions and evaluated the influence of these conditions in developing acute myocardial infarction. Design and methods This was a population-based cohort study involving 27,204 individuals ≥ 60 years of age in Tarragona (Catalonia, Spain). Data on all cases of hospitalised acute myocardial infarction were collected from 1 December 2008–30 November 2011. Incidence rates and 30-day mortality were estimated according to age, sex, chronic illnesses and underlying conditions. Multivariable Cox regression analysis was used to calculate hazard ratios and to estimate the association between baseline conditions and risk of developing acute myocardial infarction. Results The incidence of acute myocardial infarction was 475 per 100,000 person-years. Maximum rates appeared among individuals with history of coronary artery disease (2839 per 100,000), chronic severe nephropathy (1407 per 100,000), atrial fibrillation (1226 per 100,000), chronic heart disease (1149 per 100,000), history of stroke (1147 per 100,000) and diabetes mellitus (914 per 100,000). Thirty-day mortality was 15.3% overall, reaching 31.6% among patients over 80 years. In the multivariable analysis, history of coronary artery disease, age > 70 years, sex male, chronic heart disease, history of stroke, atrial fibrillation, diabetes mellitus and hypertension emerged as significantly associated with an increased risk of acute myocardial infarction. Conclusions The incidence and mortality of acute myocardial infarction remain considerable in our setting. Considering classical major risk factors, diabetes mellitus and hypertension were the underlying conditions most strongly associated with an increased risk in our study population.

scholarly journals Association of Level of Physical Exertion with Acute Myocardial Infarction in Bangladeshi Population

2016 ◽  
Vol 8 (2) ◽  
pp. 115-122
Author(s):  
Md Kamrul Azad ◽  
Abdul Wadud Chowdhury ◽  
Mohammad Arifur Rahman ◽  
Shohael M Arafat ◽  
Sheikh Foyez Ahmed ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Physical Exertion ◽  
Cross Sectional Study ◽  
College Hospital ◽  
Cross Sectional ◽  
Metabolic Equivalents ◽  
Increased Risk ◽  
History Of ◽  
Bangladeshi Population

Background: Evidences suggest that heavy physical exertion can trigger the onset of acute myocardial infarction. But there have been no clean cut data in Bangladesh about the risk of myocardial infarction during and after heavy exertion. To address this question the study was conducted.Methods: It was a multicentre cross sectional study was conducted from July 2012 to June 2013 with patient of diagnosed acute myocardial infarction (AMI) admitted in department of cardiology of National Institute of Cardiovascular Diseases (NICVD), Bangabandhu Sheikh Mujib Medical University (BSMMU) and Dhaka Medical College Hospital (DMCH). From selected samples, two hours activity prior to onset of symptom of AMI was asked according to standard questionnaire. Activities were quantified on a scale from 1 to 8 metabolic equivalents (METs) according to generally accepted values. Collected data were analyzed by SPSS version 16.Results: In this study 246 patients (74 .4 percent of whom were men; mean age [±SD], 64.68 ± 7.63 years) were interviewed. The study showed that 11.38% patients were engaged in strenuous physical exertion (e” 6 METs) within two hours prior to symptom onset of AMI. Strenuous exertion group of AMI patients were all most all sedentary worker [26 (92.86%) of 28]. Most of the patients (82.14 %) of strenuous group had history of less than 8 hours work per day. Strenuous exertion group had history of longtime exertion (72.57%, 1-2 hours) than non-strenuous group (42.66%, <0.5 hours). Moreover, 67.86% AMI patients of strenuous exertion group had experienced irregular exertion whereas most of the patients (64.22%) of non strenuous group had a history of regular exertion.Conclusions: The result of the study indicates that a period of strenuous physical activity is associated with increased risk of having AMI, particularly among patients of sedentary worker who have dyslipidemia and who exercise irregularly. Those who exercise regularly have lower chances of AMI as shown by the negative correlation.Cardiovasc. j. 2016; 8(2): 115-122

scholarly journals Outcome of Acute Myocardial Infarction Patients Admitted in a Tertiary Care Hospital

2017 ◽  
Vol 28 (1) ◽  
pp. 6-8
Author(s):  
Mona Islam ◽  
Biplob Bhattacharjee ◽  
Md Abu Yusuf Chowdhury ◽  
Abu Naser Siddique ◽  
Abul Mansur Md Rezaul Karim
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiac Arrest ◽  
Tertiary Care Hospital ◽  
Communicable Disease ◽  
Tertiary Care ◽  
Care Hospital ◽  
Risk Of Death ◽  
Increased Risk ◽  
History Of

Acute myocardial infarction (AMI) is a common non - communicable disease prevailing in developed as well as in developing countries like Bangladesh, causing a great number of mortality and morbidity and impart a huge economic burden to family as well as to society. This study was designed to see the various complications and outcome of the patients of AMI, admitted in a tertiary care hospital in Bangladesh. In this observational study, 100 patient of AMI admitted in Cardiology ward of CMCH were enrolled. Clinical diagnosis was made from history and clinical examination and confirmed by ECG and biochemical markers. Informed written consent was taken from the patient or from the patient's attendant. Among the 100 cases of AMI, 89% were suffering from STEMI and 11% were from NSTEMI. Most of the patients (39%) were in 50-59 years age group. Majority of patient had chest pain (52%), followed by dyspnoea (23%), palpitation 10%, syncopal attack 7% and cardiac arrest 8% respectively. Important risk factors were history of smoking (37%), Diabetes (33%), Hypertension (31%), Dyslipidaemia (21%) and family history of IHD (16%). ECG showed ST-elevation in 80% of patients. It has been revealed that the important complications were cardiogenic shock(31%) followed by acute LVF(21%), bradyarrythmia (12%), tachyarrhythmia (10%), cardiac arrest(8%) and 12% patients died within 24 hours of admission. Patients with AMI have a substantially increased risk of death after hospitalization when shock, LVF or arrhythmias occur during their hospital stay. These complications should have to be treated promptly to achieve a good outcome.Medicine Today 2016 Vol.28(1): 6-8

scholarly journals MiR-126-3p and MiR-223-3p as Biomarkers for Prediction of Thrombotic Risk in Patients with Acute Myocardial Infarction and Primary Angioplasty

2021 ◽  
Vol 11 (6) ◽  
pp. 508
Author(s):  
Milan Hromadka ◽  
Zuzana Motovska ◽  
Ota Hlinomaz ◽  
Petr Kala ◽  
Frantisek Tousek ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Predictive Accuracy ◽  
Cardiovascular Death ◽  
Primary Angioplasty ◽  
Bleeding Complications ◽  
Clinical Predictors ◽  
Thrombotic Risk ◽  
Increased Risk ◽  
One Year

Aim. This study was designed to evaluate the relationship between microRNAs (miRNAs), miR-126-3p and miR-223-3p, as new biomarkers of platelet activation, and predicting recurrent thrombotic events after acute myocardial infarction (AMI). Methods and Results. The analysis included 598 patients randomized in the PRAGUE-18 study (ticagrelor vs. prasugrel in AMI). The measurements of miRNAs were performed by using a novel miRNA immunoassay method. The association of miRNAs with the occurrence of the ischemic endpoint (EP) (cardiovascular death, nonfatal MI, or stroke) and bleeding were analyzed. The miR-223-3p level was significantly related to an increased risk of occurrence of the ischemic EP within 30 days (odds ratio (OR) = 15.74, 95% confidence interval (CI): 2.07–119.93, p = 0.008) and one year (OR = 3.18, 95% CI: 1.40–7.19, p = 0.006), respectively. The miR-126-3p to miR-223-3p ratio was related to a decreased risk of occurrence of EP within 30 days (OR = 0.14, 95% CI: 0.03–0.61, p = 0.009) and one year (OR = 0.37, 95% CI: 0.17–0.82, p = 0.014), respectively. MiRNAs were identified as independent predictors of EP even after adjustment for confounding clinical predictors. Adding miR-223-3p and miR-126-3p to miR-223-3p ratios as predictors into the model calculating the ischemic risk significantly increased the predictive accuracy for combined ischemic EP within one year more than using only clinical ischemic risk parameters. No associations between miRNAs and bleeding complications were identified. Conclusion. The miR-223-3p and the miR-126-3p are promising independent predictors of thrombotic events and can be used for ischemic risk stratification after AMI.

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