scholarly journals Prognostic Significance of Exercise Plasma Noradrenaline Levels for Cardiac Death in Patients With Mild Heart Failure

2002 ◽  
Vol 66 (3) ◽  
pp. 261-261 ◽  
Author(s):  
Toru Kinugawa ◽  
Kazuhide Ogino ◽  
Shuichi Osaki ◽  
Masahiko Kato ◽  
Osamu Igawa ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Death ◽  
Prognostic Significance ◽  
Plasma Noradrenaline ◽  
Mild Heart Failure ◽  
Noradrenaline Levels

scholarly journals Prognostic significance of dipstick proteinuria in heart failure with preserved ejection fraction: insight from the PURSUIT-HFpEF registry

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e049371
Author(s):  
Bolrathanak Oeun ◽  
Shungo Hikoso ◽  
Daisaku Nakatani ◽  
Hiroya Mizuno ◽  
Shinichiro Suna ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Cardiac Death ◽  
Prognostic Significance ◽  
Composite Endpoint ◽  
Preserved Ejection Fraction ◽  
Dipstick Test ◽  
Cox Regression Analysis ◽  
Urine Dipstick ◽  
Urine Dipstick Test

ObjectiveThe semiquantitative urine dipstick test is a simple and convenient method that is available in the smallest community-based healthcare clinics. We sought to clarify the prognostic significance of dipstick proteinuria in patients with heart failure (HF) with preserved ejection fraction (HFpEF).DesignA Prospective mUlticenteR obServational stUdy of patIenTs with Heart Failure with preserved Ejection Fraction (PURSUIT-HFpEF) registry.Participants and settingWe assessed 851 discharged-alive patients in the PURSUIT-HFpEF registry who were initially hospitalised due to an acute decompensated HFpEF (EF≥50%) and elevated N-terminal-pro-brain natriuretic peptide (≥400 ng/L) at Osaka University Hospital and other 30 affiliated hospitals in the Kansai region of Japan. Patients received a urine dipstick test, and were divided into two groups according to the absence or presence of proteinuria. A trace or more of dipstick proteinuria was defined as the presence of proteinuria.Main outcome measuresA composite of cardiac death or HF rehospitalisation.ResultsMedian age was 83 years and 473 patients (55.6%) were female. Five hundred and two patients (59%) were proteinuria (−) and 349 patients (41%) were proteinuria (+). The composite endpoint and HF rehospitalisation occurred more often in proteinuria (+) individuals than proteinuria (−) individuals (log-rank p=0.006 and p=0.007, respectively); but cardiac death did not (log-rank p=0.139). Multivariable Cox regression analysis showed that the presence of proteinuria was associated with the composite endpoint (HR: 1.47, 95% CI 1.07 to 2.01, p=0.016), and HF rehospitalisation (HR: 1.48, 95% CI 1.07 to 2.05, p=0.020), but not with cardiac death (HR: 1.52, 95% CI 0.83 to 2.76, p=0.172).ConclusionsDipstick proteinuria may be a prognostic marker in patients with HFpEF. Evaluation of proteinuria by a urine dipstick test may be a simple but useful method for risk stratification in HFpEF.UMIN-CTR IDUMIN000021831.

scholarly journals Prognostic Significance of Left Ventricular Fibrosis Assessed by T1 Mapping in Patients with Atrial Fibrillation and Heart Failure

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Lei Zhao ◽  
Songnan Li ◽  
Xiaohai Ma ◽  
Rong Bai ◽  
Nian Liu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Cardiac Death ◽  
T1 Mapping ◽  
Volume Fraction ◽  
Adverse Outcome ◽  
Extracellular Volume ◽  
Prognostic Significance ◽  
Multivariable Analysis ◽  
Left Ventricular

Abstract This study sought to investigate whether left ventricular (LV) fibrosis quantified by T1 mapping can be used as a biomarker to predict outcome in patients with atrial fibrillation (AF) and heart failure (HF). 108 patients with AF and HF were included in this study. They underwent cardiac magnetic resonance, including T1 mapping sequence to assess LV fibrosis between May 2014 to May 2016. Patients received catheter ablation for AF and pharmacological treatment for HF. The primary endpoint was a composite adverse outcome of cardiac death, subsequent HF or stroke, subsequent HF was the secondary endpoint. During follow up (median: 23 months, Q1-Q3: 11 to 28 months), 1 cardiac death, 12 strokes, and 42 HF episodes occurred. LV extracellular volume fraction (ECV) was predictive of composite adverse outcome and subsequent HF (all p < 0.001). In multivariable analysis, LV ECV was an independent predictor of composite adverse outcome (hazard ratio (HR): 1.258, 95% confidence interval (CI): 1.140–1.388, p < 0.001) and subsequent HF (HR: 1.223, 95% CI: 1.098–1.363, p < 0.001). LV fibrosis measured by T1 mapping indices significantly predicts composite adverse outcomes and subsequent HF in patients with AF and HF.

514 Prognostic significance of bioelectrical evaluation of body composition in chronic heart failure

2003 ◽  
Vol 2 (1) ◽  
pp. 105
Author(s):  
F MASSARI ◽  
P GUIDA ◽  
F MASTROPASQUA ◽  
M IACOVIELLO ◽  
B RIZZON ◽  
...  
Keyword(s):  
Heart Failure ◽  
Body Composition ◽  
Chronic Heart Failure ◽  
Prognostic Significance

Beta-1 adrenoceptor gene polimorphism in heart failure: clinical and prognostic significance in female patients

2008 ◽  
Vol 7 ◽  
pp. 90-91
Author(s):  
S NODARI ◽  
M METRA ◽  
A MANERBA ◽  
G MILESI ◽  
N BERLINGHIERI ◽  
...  
Keyword(s):  
Heart Failure ◽  
Prognostic Significance ◽  
Female Patients
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