The Influence of Various Organ-Extracts upon the Circulatory System : The Third Report. The Influence of Thymus-Extract upon the Blood Pressure and the Pulse of Rabbits

1937 ◽  
Vol 2 (12) ◽  
pp. 661-665
Author(s):  
Takamasa Fukazawa
2020 ◽  
pp. 30-40
Author(s):  
M. G. Melnik

Purpose. To study the dynamics of blood pressure (BP) indicators under the influence of exogenously administered melatonin (Melatonin-SZ, Severnaya Zvezda, Russia) with various manifestations of desynchronosis of circadian BP rhythms (arterial hypertension – AH, high normal blood pressure) to determine the scheme of their effective compensation. Material and methods. The study included 101 patients with desynchronosis of circadian rhythms of blood pressure – 52 patients with hypertension, constituting the first and second groups, and 49 individuals with high normal blood pressure, representing the third and fourth groups. Patients of the second and fourth groups received conservative therapy, patients of the first and third groups combined it with melatonin. All patients underwent measurements of office blood pressure, home monitoring of blood pressure (ABPM), electrocardiography, 24-hour blood pressure monitoring (ABPM). Results and discussion. In patients of the first and third groups, compared with the traditional treatment groups, by the end of the observation period, a significantly (p < 0.05) decrease in office systolic blood pressure (SBP) / diastolic blood pressure (DBP) was established: in the first group compared with the second – 1.11 / 1.13 times, in the third group compared to the fourth – 1.43 / 1.58 times; significantly more (p < 0.05) pronounced decrease in SBP / DBP during DMAD – by 1.08 / 1.17 and 1.58 / 1.62 times, respectively, Significantly (p < 0.05) more pronounced decrease in average daily, average daily and average nighttime SBP / DBP during ABPM – by 1.13 / 1.20, 1.11 / 1.20, 1.23 / 1.25 and 1.47 / 1.31, 1.42 / 1.19, 1.54 / 1.41 times, respectively; reliably (p < 0.05) more frequent registration of the dipper rhythm type SBP / DBP – 1.6 / 1.4 and 1.6 / 1.4 times, respectively. In addition, the dynamics of patients in the first and third groups showed a significant (p < 0.05) decrease in the mean daily and mean nighttime SBP / DBP variability (SBP in the first group by 27.3 and 41.3 %, respectively; DBP in the first group by 20.1 and 26.3 %, respectively; SBP in the third group by 13.5 and 25.2 %, respectively; DBP in the third group by 12.2 and 28.2 %, respectively). Conclusions. With various manifestations of desynchronosis of circadian rhythms of blood pressure (AH, high normal blood pressure), the prescription of melatonin (Melatonin-SZ, Severnaya Zvezda, Russia) at a dose of 3 mg per day 30–40 minutes before bedtime for a month against the background of non-drug therapy and antihypertensive drugs led to a significantly more effective decrease in blood pressure at its office measurement, DMAD, ABPM with an improvement in the circadian rhythm of blood pressure and normalization of blood pressure variability.


Author(s):  
Sergey Aleksandrovich Kuzmin ◽  
Lyubov Kuzminichna Grigorieva ◽  
Kargla Amanzhulovna Izbagambetova

In the context of the reform of the Armed Forces of the Russian Federation, the issues of recruiting troops with healthy, physically developed and mentally stable young conscripts are of paramount importance. Only citizens "A" - fit for military service and "B" fit for military service with minor restrictions are subject to conscription. When analyzing the results of medical examination of persons of military age, it was found that over the studied period of time, fitness for military service for health reasons decreased by 3.8% (from 78.3% in 2016 to 74.5% in 2020). However, despite the general decrease in fitness for military service, there is an increase in the fitness for military service "A" by 13.5% (from 23.4% in 2016 to 36.9% in 2020). Every year, during the period of work of the draft commissions, a significant number of citizens (more than 10%) were sent for additional examination to medical organizations. As a rule, the examination of conscripts was carried out on an outpatient basis (up to 85%) and much less often in an inpatient setting (up to 15%). The first place was occupied by diseases of the musculoskeletal system and connective tissue, which accounted for 24.9%. Mental and behavioral disorders ranked second with an indicator of 18.7%. The third place was taken by diseases of the circulatory system - 14.9%. Diseases of the eye and adnexa ranked fourth - 8.2%. Diseases of the digestive system were less common, accounting for only 4.5%. Thus, in total, the listed diseases accounted for 71.2% and were the main ones in determining the fitness of conscripts for military service for health reasons.


Author(s):  
Mariman Tjendera ◽  
Isramilda Isramilda

Noise in the workplace is often a separate problem for the workforce so that it can cause mental-emotional disturbance as well as the heart and circulatory system. According to the 2013 Basic Health Research, the prevalence of high blood pressure in Indonesia at the age of ≥18 years is 25.8%. So the researchers wanted to find a relationship between noise intensity and blood pressure. This research method was observational analytic with a cross-sectional approach conducted at PT. Bintang Intipersada Shipyard, Batam City. The sampling technique was a total sampling with a population of 100 workers in 2018 and obtained results of 61 workers determined by inclusion and exclusion criteria. The results of the study were analyzed with a frequency distribution tabulated and tested with the Pearson Product Moment Test. The results of this study worker who were exposed to noise intensity ≤85 dBA had a normal blood pressure of 8 (36.5%) people, in workers who were exposed to noise intensity ≤85 dBA had blood pressure with Pre-hypertension as many as 12 (54.5% ) people, for workers exposed to noise intensity ≤85 dBA have 1 (4.5%) blood pressure with Stage 1 Hypertension, workers who are exposed to noise intensity ≤85 dBA have blood pressure with Stage 2 Hypertension as much as 1 (4.5 %) person. While workers who are exposed to noise intensity> 85 dBA have normal blood pressure of 0 (0%) people, workers who are exposed to noise intensity> 85 dBA have blood pressure with Pre-hypertension as much as 2 (5.1%) people, workers are exposed to noise intensity> 85 dBA had blood pressure with Stage 1 Hypertension as many as 14 (35.9%) people, then workers exposed to noise intensity> 85 dBA had blood pressure with Stage 2 Hypertension as many as 23 (59%) workers. The results of the Pearson Product Moment analysis value of p = 0,000 <α 0.05, there is a relationship between noise intensity and blood pressure with the magnitude of the correlation coefficient (r) which is 0.795 meaning, there is a strong relationship. Based on this study it can be concluded that there is a significant relationship between noise intensity and blood pressure.


1982 ◽  
Vol 101 (2) ◽  
pp. 273-280 ◽  
Author(s):  
E. B. Pedersen ◽  
A. B. Rasmussen ◽  
P. Johannesen ◽  
H. J. Kornerup ◽  
S. Kristensen ◽  
...  

Abstract. Plasma renin concentration (PRC), plasma aldosterone concentration (PAC), and blood pressure were determined in the third trimester in pregnancy, 5 days and 6 months after delivery in pre-eclampsia, essential and transient hypertension in pregnancy and in normotensive pregnant and non-pregnant control subjects. PRC and PAC were elevated several fold above non-pregnant level in all groups during pregnancy. In pre-eclampsia PRC and PAC were 220 and 160%, respectively, above the levels 6 months after delivery, and thus lower than the corresponding values, 360 and 402%, in normotensive pregnancy. In essential and transient hypertension PRC and PAC increased to the same degree as during normotensive pregnancy. Urinary sodium excretion, serum sodium and creatinine clearance were reduced in pre-eclampsia, but not in essential and transient hypertension when compared to normotensive pregnant controls. All the parameters determined were the same as in non-pregnant controls 6 months after delivery in all groups. There were no correlations between blood pressure and PRC or PAC in any of the groups neither in pregnancy nor after delivery. It is concluded that the renin-aldosterone system is stimulated in lesser degree in pre-eclampsia than in both essential hypertension, transient hypertension and normotensive pregnancy, and there was no evidence for a causal relationship between the renin-aldosterone system and blood pressure neither in normotensive nor hypertensive pregnancy.


2020 ◽  
Vol 2020 ◽  
Author(s):  
Agussalim

Hypertension is a disease that usually occurs in the circulatory system which can cause an increase in blood pressure above the normal value, which exceeds 140/90 mmHg. The intention of this study aims to understand the relationship between lifestyle and the incidence of hypertension in Antang Makassar Public Health Center in 2018. This research method uses quantitative analytic motives using a cross sectional approach with a population of 46 people and a sample of 36 respondents. This research was conducted on July 14-16 June. The method used is simple random sampling and the tool used to obtain data is a questionnaire. The scale used is Liker and Guttmann scale with univariate, bivariate analysis and chi-square test with significant a = 0, 05. The results of this study indicate there is a relationship between lifestyle and the incidence of hypertension in the Makassar Antang Health Center with P = 0, 01 smaller than the value of a = 0.05. Suggestions are for hypertensive patients, namely the need to check their health routinely to health workers in order to know the development of blood pressure and obtain information from health workers.


2020 ◽  
Vol 5 (2) ◽  
pp. 99-104
Author(s):  
Evgenii L. Borschuk ◽  
Dmitrii N. Begun ◽  
Tatyana V. Begun

Objectives - to study the mortality indicators, their dynamics and structure, in the population of the Orenburg region in the period of 2011-2017. Material and methods. The study was conducted using the data from the territorial authority of statistics in the Orenburg region in the period from 2011 to 2017. The analytical, demographic and statistical methods were implemented for the study of the demographic indicators. Results. Cities and municipal settlements of the Orenburg region with high mortality indicators were included in the second and fourth clusters during the cluster analysis. The first and third clusters included cities and municipal settlements with an average mortality. The most favorable position has the Orenburg area with the lowest mortality rate in the region in 2017 - 8.4%. The dynamics of mortality rates among the male and female population tends to decrease, more pronounced dynamics is in men. Though, the male population is characterized by higher mortality rates in all age groups. The leading position among the causes of death is taken by diseases of the circulatory system (46.3% of the total mortality). The second position is occupied by tumors (17.2%), the third - by external causes (8.4%). Mortality from circulatory system diseases and from external causes has reduced. The dynamics of mortality from tumors does not change significantly. The rank of leading causes of death is not identical in the clusters: in the third and fourth clusters, the other causes occupy the second place in the structure of mortality, while tumors occupy the third. Conclusion. In the Orenburg region, the mortality rate is higher than overage in the Russian Federation by 0.9 per 1000 people. The study revealed significant territorial differences in the mortality rates. In general, the mortality among men in all age groups is higher than the mortality of women. The mortality rate from diseases of the circulatory system plays the leading role in the structure of mortality, but has the tendency for decline. Until 2006, the mortality from external causes ranked the second place, now the second place is taken by death from tumors The mortality from external causes is decreasing; mortality from tumors does not change significantly. The obtained results could be used by local authorities in developing the program of public health protection and assessing its effectiveness.


Author(s):  
S. N. Vadzyuk ◽  
L. I. Horban ◽  
I. Ya. Papinko

Background. The individual and typological features of the central nervous system are interpreted as highly genetically determined. Each somatotype is characterized by morphofunctional features of the activity of different systems, including the circulatory system. Objective. The aim of the research was to study the features of the main individual and typological parameters of higher nervous activity in persons of different somatotype with normal and high blood pressure (BP). Methods. In the control group of the surveyed patients the BP value corresponded to the optimal level according to the WHO classification (125 people). The second group consisted of individuals, whose systolic blood pressure exceeded 130 mmHg at the time of the study and (or) diastolic – 85 mmHg (135 people). Somatotyping technique by Carter and Heath was used. Functional mobility (FMNP) and strength of nervous processes (SNP) were determined using the Diagnost-1 program (Makarenko and Lizogub). Results. In the individuals with predominance of ecto- and mesomorphic somatotype component, higher levels of major nervous processes were reported in response to strenuous processing of information, which was associated with more advanced mechanisms of information processing, its neurophysiological support. In people with endomorphic somatotype the lower levels of FMNP and SNP were clearly detected that could indicate that the speed characteristics of the nervous processes in them are at a lower level. Conclusions. In normal blood pressure, the highest indicator of FMNP was found in the individuals with predominance of ecto- and mesomorphic component. In the group with high blood pressure, the indicator at the level below the average was in endomorphs. Predominance of the ectomorphic component tended to increase in the surveyed, and in the mesomorphs was at the average level. The lowest level of SNP was found in the individuals with endomorphic somatotype of both groups.


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