Poly(L-lactic acid) Microfiltration Membrane Formation via Thermally Induced Phase Separation with Drying

2011 ◽  
Vol 44 (7) ◽  
pp. 467-475 ◽  
Author(s):  
Takaaki Tanaka ◽  
Masatou Ueno ◽  
Youhei Watanabe ◽  
Tomoaki Kouya ◽  
Masayuki Taniguchi ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Phase Separation ◽  
Thermally Induced Phase Separation ◽  
Membrane Formation ◽  
Thermally Induced ◽  
Microfiltration Membrane

Structure–property relation of porous poly (l-lactic acid) scaffolds fabricated using organic solvent mixtures and controlled cooling rates and its bio-compatibility with human adipose stem cells

2018 ◽  
Vol 33 (4) ◽  
pp. 397-415 ◽  
Author(s):  
Harish Chinnasami ◽  
Jeff Gimble ◽  
Ram V Devireddy
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Lactic Acid ◽  
Phase Separation ◽  
Mechanical Strength ◽  
Separation Method ◽  
Thermally Induced Phase Separation ◽  
Cooling Rates ◽  
Thermally Induced ◽  
Pore Sizes

Thermally induced phase separation method was used to make porous three-dimensional poly (l-lactic acid) scaffolds. The effect of imposed thermal profile during freezing of the poly (l-lactic acid) in dioxane solution on the scaffold was characterized by their micro-structure, porosity (%), pore sizes’ distribution, and mechanical strength. The porosity (%) decreased considerably with increasing concentrations of poly (l-lactic acid) in the solution, while a decreasing trend was observed with increasing cooling rates. The mechanical strength increases with increase in poly (l-lactic acid) concentration and also with increase in the cooling rate for both types of solvents. Therefore, mechanical strength was increased by higher cooling rates while the porosity (%) remained relatively consistent. Scaffolds made using higher concentrations of poly (l-lactic acid; 7% and 10% w/v) in solvent showed better mechanical strength which improved relatively with increasing cooling rates (1°C–40°C/min). This phenomenon of enhanced structural integrity with increasing cooling rates was more prominent in scaffolds made from higher initial poly (l-lactic acid) concentrations. Human adipose–derived stem cells were cultured on these scaffold (7% and 10% w/v) prepared by thermally induced phase separation at all cooling rates to measure the cell proliferation efficiency as a function of their micro-structural properties. Mean pore sizes played a crucial role in cell proliferation than percent porosity since all scaffolds were >88% porous. The viability percent of human adipose tissue–derived adult stem cells increased consistently with longer periods of culture. Thus, poly (l-lactic acid) scaffolds prepared by thermally controlled thermally induced phase separation method could be a prime candidate for making ex vivo tissue-engineered grafts for surgical implantation.

scholarly journals Membrane Formation via Thermally-Induced Phase Separation from Polypropylene/Fatty Acids Systems.

MEMBRANE ◽  
1994 ◽  
Vol 19 (4) ◽  
pp. 242-249 ◽  
Author(s):  
Jae-Jin Kim ◽  
Jeong Rim Hwang ◽  
Un Young Kim ◽  
Sung Soo Kim
Keyword(s):  
Fatty Acids ◽  
Phase Separation ◽  
Thermally Induced Phase Separation ◽  
Membrane Formation ◽  
Thermally Induced

Effect of diluent on poly(ethylene-co-vinyl alcohol) hollow-fiber membrane formation via thermally induced phase separation

2004 ◽  
Vol 95 (2) ◽  
pp. 219-225 ◽  
Author(s):  
Mengxian Shang ◽  
Hideto Matsuyama ◽  
Masaaki Teramoto ◽  
Junpei Okuno ◽  
Douglas R. Lloyd ◽  
...  
Keyword(s):  
Phase Separation ◽  
Hollow Fiber ◽  
Vinyl Alcohol ◽  
Hollow Fiber Membrane ◽  
Thermally Induced Phase Separation ◽  
Fiber Membrane ◽  
Membrane Formation ◽  
Thermally Induced ◽  
Poly Ethylene
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