scholarly journals Determination of Selected Corticosteroids in Sewage-treatment-plant Samples by Liquid Chromatography-mass Spectrometry

2010 ◽  
Vol 56 (5) ◽  
pp. 547-556 ◽  
Author(s):  
Yuko Kitaichi ◽  
Aoi Miyamoto ◽  
Kazuo Uchikura
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Sewage Treatment ◽  
Sewage Treatment Plant ◽  
Treatment Plant ◽  
Liquid Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry ◽  
Plant Samples

scholarly journals Simultaneous Determination of Pharmaceuticals by Solid-phase Extraction and Liquid Chromatography–tandem Mass Spectrometry: A Case Study from Sharjah Sewage Treatment Plant

2019 ◽  
Author(s):  
Mohammad H. Semreen ◽  
Abdallah Shanableh ◽  
Lucy Semerjian ◽  
Hasan Alniss ◽  
Muath Mousa ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Solid Phase ◽  
Sewage Treatment ◽  
Sewage Treatment Plant ◽  
Treatment Plant ◽  
Tandem Mass ◽  
Phase Extraction

The present work describes the optimization and validation of a highly selective and sensitive analytical method using solid phase extraction and liquid chromatography tandem mass spectrometry (SPE LC-MS/MS) for the determination of some frequently prescribed pharmaceuticals in urban wastewater received and treated by Sharjah sewage treatment plant (STP). The extraction efficiency of different SPE cartridges was tested and the simultaneous extraction of pharmaceuticals was successfully accomplished using hydrophilic-lipophilic-balanced reversed phase Waters® Oasis HLB cartridge (200 mg/ 6 mL) at pH 3. The analytes were separated on an Aquity BEH C18 column (1.7 µm, 2.1 mm x 150 mm) using gradient elution and the mass spectrometric analysis were performed in multiple reactions monitoring (MRM) selecting two precursor ions to produce ion transition for each pharmaceutical using positive electrospray ionization (+ESI) mode. The correlation coefficient values in the linear calibration plot for each target compound exceeded 0.99 and the recovery percentages of the investigated pharmaceuticals were more than 84%. Limit of detection (LOD) varied between 0.1-1.5 ng/L and limit of quantification (LOQ) was 0.3-5 ng/L for all analytes. The precision of the method was calculated as the relative standard deviation (RSD%) of replicate measurements and was found to be in the ranges of 2.2% to 7.7% and 2.2% to 8.6% for inter and intra-day analysis, respectively. All of the obtained validation parameters satisfied the requirements and guidelines of analytical method validation.

scholarly journals Determination of regulatory ionophore coccidiostat residues in feedstuffs at carry-over levels by liquid chromatography-mass spectrometry

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0182831 ◽  
Author(s):  
Loredana Annunziata ◽  
Pierina Visciano ◽  
Arianna Stramenga ◽  
Maria Novella Colagrande ◽  
Guido Campana ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Liquid Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry ◽  
Carry Over
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