scholarly journals Biochemical Studies on the Protective Effect of Betaine on Mitochondrial Function in Experimentally Induced Myocardial Infarction in Rats

2007 ◽  
Vol 53 (6) ◽  
pp. 671-681 ◽  
Author(s):  
Balaraman Ganesan ◽  
Rangasamy Rajesh ◽  
Rangasamy Anandan ◽  
Nanjappan Dhandapani
Keyword(s):  
Myocardial Infarction ◽  
Protective Effect ◽  
Mitochondrial Function ◽  
Biochemical Studies ◽  
Experimentally Induced

scholarly journals Protective effect of morin on cardiac mitochondrial function during isoproterenol-induced myocardial infarction in male Wistar rats

Redox Report ◽  
2012 ◽  
Vol 17 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Khalid S. Al Numair ◽  
Govindasamy Chandramohan ◽  
Mohammed A. Alsaif ◽  
Arul Albert Baskar
Keyword(s):  
Myocardial Infarction ◽  
Protective Effect ◽  
Mitochondrial Function ◽  
Wistar Rats ◽  
Male Wistar Rats

Protective effect of aspartate and glutamate on cardiac mitochondrial function during myocardial infarction in experimental rats

2008 ◽  
Vol 176 (2-3) ◽  
pp. 227-233 ◽  
Author(s):  
Ramalingam Sivakumar ◽  
Pon Velayutham Anandh Babu ◽  
Chennam Srinivasulu Shyamaladevi
Keyword(s):  
Myocardial Infarction ◽  
Protective Effect ◽  
Mitochondrial Function

scholarly journals Protective Effects of Taurine Chloramine on Experimentally Induced Colitis: NFκB, STAT3, and Nrf2 as Potential Targets

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 479
Author(s):  
Seong Hoon Kim ◽  
Hye-Won Yum ◽  
Seung Hyeon Kim ◽  
Wonki Kim ◽  
Su-Jung Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Parent Compound ◽  
Oxidative Stress Marker ◽  
Heme Oxygenase 1 ◽  
Trinitrobenzene Sulfonic Acid ◽  
Protective Effects ◽  
Taurine Chloramine ◽  
Proinflammatory Mediators ◽  
Experimentally Induced

Taurine chloramine (TauCl) is an endogenous anti-inflammatory substance which is derived from taurine, a semi-essential sulfur-containing β-amino acid found in some foods including meat, fish, eggs and milk. In general, TauCl as well as its parent compound taurine downregulates production of tissue-damaging proinflammatory mediators, such as chemokines and cytokines in many different types of cells. In the present study, we investigated the protective effects of TauCl on experimentally induced colon inflammation. Oral administration of TauCl protected against mouse colitis caused by 2,4,6-trinitrobenzene sulfonic acid (TNBS). TauCl administration attenuated apoptosis in the colonic mucosa of TNBS-treated mice. This was accompanied by reduced expression of an oxidative stress marker, 4-hydroxy-2-nonenal and proinflammatory molecules including tumor necrosis factor-α, interleukin-6 and cyclooxygenase-2 in mouse colon. TauCl also inhibited activation of NFκB and STAT3, two key transcription factors mediating proinflammatory signaling. Notably, the protective effect of TauCl on oxidative stress and inflammation in the colon of TNBS-treated mice was associated with elevated activation of Nrf2 and upregulation of its target genes encoding heme oxygenase-1, NAD(P)H:quinone oxidoreductase, glutamate cysteine ligase catalytic subunit, and glutathione S-transferase. Taken together, these results suggest that TauCl exerts the protective effect against colitis through upregulation of Nrf2-dependent cytoprotective gene expression while blocking the proinflammatory signaling mediated by NFκB and STAT3.

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