scholarly journals Biomarkers of Exposure to Polycyclic Aromatic Hydrocarbons and Related Compounds

2007 ◽  
Vol 53 (6) ◽  
pp. 631-638 ◽  
Author(s):  
Akira Toriba ◽  
Kazuichi Hayakawa
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Biomarkers Of Exposure ◽  
Polycyclic Aromatic ◽  
Related Compounds

scholarly journals Understanding the reactivity of polycyclic aromatic hydrocarbons and related compounds

2020 ◽  
Vol 11 (15) ◽  
pp. 3769-3779 ◽  
Author(s):  
Israel Fernández
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Decomposition Analysis ◽  
Energy Decomposition Analysis ◽  
Energy Decomposition ◽  
Analysis Methods ◽  
Polycyclic Aromatic ◽  
Strain Model ◽  
Related Compounds

This perspective article summarizes recent applications of the combined activation strain model of reactivity and the energy decomposition analysis methods to the study of the reactivity of polycyclic aromatic hydrocarbons and related compounds.

scholarly journals Nicotine and Toxicant Exposure Among Concurrent Users (Co-Users) of Tobacco and Cannabis

2019 ◽  
Vol 22 (8) ◽  
pp. 1354-1363 ◽  
Author(s):  
Danielle M Smith ◽  
Richard J O’connor ◽  
Binnian Wei ◽  
Mark Travers ◽  
Andrew Hyland ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Health Effects ◽  
Aromatic Hydrocarbons ◽  
Tobacco Product ◽  
Cannabis Use ◽  
Urine Samples ◽  
Potential Health ◽  
Biomarker Of Exposure ◽  
Biomarkers Of Exposure ◽  
Polycyclic Aromatic

Abstract Background Smoking cannabis may potentially increase exposure to numerous toxic chemicals that are commonly associated with tobacco use. There is a paucity of data related to toxicant exposures among concurrent users of tobacco and cannabis (co-users). Methods Data are from the Population Assessment of Tobacco and Health Study Wave 1 Biomarker Restricted-Use Files. Analyses focused on adults who provided urine samples (N = 5859). Urine samples were analyzed for biomarkers of exposure to nicotine, tobacco-specific nitrosamines, polycyclic aromatic hydrocarbons, and volatile organic compounds. Using weighted linear regression, we compared adjusted geometric mean concentrations of 15 biomarkers between user groups of various tobacco product types according to their self-reported past 30-day cannabis use. Results Past 30-day cannabis use was similar across various types of tobacco product use subgroups (range: 13%–23%) and significantly more common compared to non-tobacco users (1.0%; p < .001). Across all groups of tobacco users, those who co-used cannabis exhibited significantly higher concentrations of the biomarker of exposure to acrylonitrile (CYMA) compared to non-cannabis users (by 39%–464%). Tobacco–cannabis co-users also showed significantly elevated levels of the biomarker of exposure to acrylamide (AAMA) compared to exclusive tobacco users, and significantly higher exposure to many polycyclic aromatic hydrocarbons (including fluorene and pyrene). Conclusions Co-users exhibited higher concentrations for biomarkers of exposure to many combustion byproducts, compared to exclusive tobacco users. More robust measurements of cannabis use can address potential confounding in assessments of exposures to tobacco-related constituents, and potential health effects resulting from co-use. Implications With disproportionately greater rates of cannabis use occurring among tobacco users, it is critical to consider how concurrent cannabis use may influence health-related outcomes among smokers. Our findings suggest potential additive toxicant exposures among co-users of tobacco and cannabis. Lack of consideration and measurement of cannabis use in assessing tobacco-related exposures may confound estimates thought to be attributable to tobacco, particularly for non-specific biomarkers. Assessing tobacco and cannabis use in tandem will allow for more precise measurement of outcomes related to one or both substances, and can provide additional information on potential health effects related to co-use.

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