scholarly journals Thapsigargin Enhances Cell Death in the Gastrointestinal Stromal Tumor Cell Line, GIST-T1, by Treatment with Imatinib (Glivec)

2006 ◽  
Vol 52 (2) ◽  
pp. 110-117 ◽  
Author(s):  
Toufeng Jin ◽  
Hajime Nakatani ◽  
Takahiro Taguchi ◽  
Hiroshi Sonobe ◽  
Norihito Morimoto ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cell ◽  
Gastrointestinal Stromal Tumor ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Stromal Tumor

scholarly journals STI571 (Glivec) inhibits the interaction between c-KIT and heat shock protein 90 of the gastrointestinal stromal tumor cell line, GIST-T1

2005 ◽  
Vol 96 (2) ◽  
pp. 116-119 ◽  
Author(s):  
Hajime Nakatani ◽  
Michiya Kobayashi ◽  
Toufeng Jin ◽  
Takahiro Taguchi ◽  
Takeki Sugimoto ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cell ◽  
Gastrointestinal Stromal Tumor ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Heat Shock Protein 90 ◽  
Stromal Tumor

scholarly journals Neferine inhibits growth and migration of gastrointestinal stromal tumor cell line GIST-T1 by up-regulation of miR-449a

2019 ◽  
Vol 109 ◽  
pp. 1951-1959 ◽  
Author(s):  
Fangxi Xue ◽  
Zhaoxia Liu ◽  
Jian Xu ◽  
Xiaoguang Xu ◽  
Xingtian Chen ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Gastrointestinal Stromal Tumor ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Stromal Tumor ◽  
And Migration

scholarly journals GCT-46. MULTI-KINASE INHIBITORS AS NOVEL THERAPEUTIC AGENTS AGAINST INTRACRANIAL NON-GERMINOMATOUS GERM CELL TUMORS

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii337-iii337
Author(s):  
Eita Uchida ◽  
Tatsuya Ozawa ◽  
Masamichi Takahashi ◽  
Ryo Nishikawa ◽  
Koichi Ichimura ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cell ◽  
Germ Cell ◽  
Cell Line ◽  
Kinase Inhibitors ◽  
Germ Cell Tumors ◽  
Tumor Cell Line ◽  
Membrane Receptors ◽  
Antitumor Effects ◽  
Novel Therapeutic

Abstract Central nervous system germ cell tumors (CNS GCTs) are rare intracranial malignancies developing in adolescents and young adults which relatively frequently occur in East Asia region of the world including Japan. However, among CNS GCTs, non-germinomatous germ cell tumors (NGGCTs) are highly resistant to the current chemoradiotherapies, and the prognosis of CNS NGGCTs is still extremely poor. Therefore, development of novel therapeutic strategy against CNS NGGCTs is urgently needed. In this study, we screened small molecule inhibitors of kinases specifically targeting cell membrane receptors, such as receptor tyrosine kinases, and their related molecular signaling, which could effectively exert antitumor effects against NGGCT cells. As the NGGCT model cells, the Tcam2 cell, a mixed germ cell tumor cell line composed of germinoma and embryonal carcinoma components, and the YST1 cell, a novel yolk sac tumor cell line established in our institute, were used. As a result, effective induction of cell death in both cell lines was confirmed only by treatment with two multi-kinase inhibitors. Immunoblotting revealed these multi-kinase inhibitors suppressed activation of various kinases concurrently. Furthermore, these multi-kinase inhibitors also triggered cell death in the Tcam2 cell stably expressing mutant KIT, the most common oncogenic driver genes of CNS GCTs, suggesting that these inhibitors would be also effective against CNS GCTs harboring activated KIT mutants. In vivo studies of these multi-kinase inhibitors using CNS GCT xenografts are currently on going.

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