scholarly journals Apoptosis Induction of Mouse Splenic Cells by Exposure to High-Level 17β-Estradiol and Endocrine Disrupting Chemicals

2004 ◽  
Vol 50 (3) ◽  
pp. 248-256 ◽  
Author(s):  
Humitoshi Sakazaki ◽  
Hitoshi Ueno ◽  
Katsuhiko Nakamuro
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Apoptosis Induction ◽  
Endocrine Disrupting ◽  
Splenic Cells ◽  
17Β Estradiol ◽  
High Level

Assessing Estrogenic Activities of Selected Endocrine Disrupting Chemicals and their Combination Effects

2013 ◽  
Vol 765-767 ◽  
pp. 2944-2948 ◽  
Author(s):  
Xiao Ling Shao ◽  
Wen Qi Zhong ◽  
Xiao Yan Ma ◽  
Ang Gao ◽  
Xiang Yang Wu ◽  
...  
Keyword(s):  
Binary Systems ◽  
Endocrine Disrupting Chemicals ◽  
Concentration Addition ◽  
Multicomponent Mixtures ◽  
Yeast Two Hybrid ◽  
Yeast Two Hybrid System ◽  
Endocrine Disrupting ◽  
17Β Estradiol ◽  
Ethylhexyl Phthalate ◽  
Two Hybrid

Yeast two-hybrid system was used to investigate the estrogenic activities of 13 kinds of representative endocrine disrupting chemicals (EDCs) and their combinary effects. Results show that the order of estrogenic potencies for these chemicals is: 17α-ethynylestradiol>diethylstilbestrol >17β-estradiol>estrone>estriol>branchedp-nonylphenol>4-t-octylphenol>bisphenol A>diethyl phthalate>4-n-nonylphenol>di-(2-ethylhexyl) phthalate>dibutyl phthalate>dimethyl phthalate. The mixture effects of multiple EDCs were compared to those obtained from individual chemicals, using the model of concentration addition. Results reveal that the estrogenicities of multicomponent mixtures of more than three (including three) of EDCs follow antagonistic effects, while there is no definite conclusion for binary systems. The less than additive effects were also confirmed in the spiked experiments conducted in the extracts of real water samples.

scholarly journals Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor

2020 ◽  
Vol 17 (16) ◽  
pp. 5664 ◽  
Author(s):  
Chao Zhang ◽  
Tiziana Schilirò ◽  
Marta Gea ◽  
Silvia Bianchi ◽  
Angelo Spinello ◽  
...  
Keyword(s):  
Competitive Inhibition ◽  
Estrogenic Activity ◽  
Endocrine Disrupting Chemicals ◽  
Binding Mode ◽  
Inhibition Mechanism ◽  
Aromatase Activity ◽  
Docking Simulations ◽  
Potential Binding ◽  
Endocrine Disrupting ◽  
17Β Estradiol

The intensive use of pesticides has led to their increasing presence in water, soil, and agricultural products. Mounting evidence indicates that some pesticides may be endocrine disrupting chemicals (EDCs), being therefore harmful for the human health and the environment. In this study, three pesticides, glyphosate, thiacloprid, and imidacloprid, were tested for their ability to interfere with estrogen biosynthesis and/or signaling, to evaluate their potential action as EDCs. Among the tested compounds, only glyphosate inhibited aromatase activity (up to 30%) via a non-competitive inhibition or a mixed inhibition mechanism depending on the concentration applied. Then, the ability of the three pesticides to induce an estrogenic activity was tested in MELN cells. When compared to 17β-estradiol, thiacloprid and imidacloprid induced an estrogenic activity at the highest concentrations tested with a relative potency of 5.4 × 10−10 and 3.7 × 10−9, respectively. Molecular dynamics and docking simulations predicted the potential binding sites and the binding mode of the three pesticides on the structure of the two key targets, providing a rational for their mechanism as EDCs. The results demonstrate that the three pesticides are potential EDCs as glyphosate acts as an aromatase inhibitor, whereas imidacloprid and thiacloprid can interfere with estrogen induced signaling.

Direct oxidation treatment by a novel 3-dimensional electrolytic cell reactor

2006 ◽  
Vol 6 (2) ◽  
pp. 87-91
Author(s):  
Y. Sakakibara ◽  
Y. Sena ◽  
M. Prosnansky
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Electrolytic Cell ◽  
Chlorinated Phenols ◽  
Direct Oxidation ◽  
Nonyl Phenol ◽  
Oxidation Treatment ◽  
3 Dimensional ◽  
Endocrine Disrupting ◽  
Cell Reactor ◽  
17Β Estradiol

The\ performance of a novel 3-dimensional electrolytic cell reactor for the treatment of dilute solutions was investigated using different dyes (potassium indigotrisulfonate (PI), Orange 2 and Amaranth) and endocrine disrupting chemicals (EDCs). Continuous experiments demonstrated that the present electrolytic cell reactor was able to directly oxidize the dyes on the surface of the electrode very quickly in response to a change in electric current. It is interesting to note that the energy consumption for the oxidation of PI and Orange 2 was significantly smaller than for the commercially available ozone generators. The electrolytic reactor was also successfully applied to the treatment of trace EDCs including 17β-estradiol, bisphenol-A, nonyl-phenol and chlorinated phenols.

2D/2D Bi2WO6/Protonated g-C3N4 Step-scheme Heterojunctions for Enhancing Photodegradation of 17β-Estradiol: Promotional Role of Electrostatic Interaction

2022 ◽  
Author(s):  
Yashi Qing ◽  
Yanxiang Li ◽  
Dan Hu ◽  
Zhiwei Guo ◽  
Yujie Yang ◽  
...  
Keyword(s):  
Human Health ◽  
Electrostatic Interaction ◽  
Estrogenic Activity ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting ◽  
17Β Estradiol

17β-Estradiol (E2) is a type of endocrine disrupting chemicals (EDCs) with the strongest estrogenic activity which poses a huge threat to the ecosystems and human health even at extremely low...

Enhanced treatment of endocrine disrupting chemicals by a granular bed electrochemical reactor

2010 ◽  
Vol 62 (10) ◽  
pp. 2218-2224 ◽  
Author(s):  
Y. Sakakibara ◽  
T. Kounoike ◽  
H. Kashimura
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Electrochemical Reactor ◽  
Granular Bed ◽  
Reactor Performance ◽  
Rate Limiting Step ◽  
Endocrine Disrupting ◽  
Film Mass Transfer ◽  
17Β Estradiol ◽  
Rate Limiting ◽  
Good Agreement

Continuous treatments of trace endocrine disrupting chemicals (EDCs) such as 17β-estradiol (E2), bisphenol-A, nonylephenol, 4-t-octyl phenol and pentachlorophenol were carried out using a granular bed electrolytic reactor. Experimental results showed that the EDCs were removed by the reactor over 150 days and removal efficiencies were nearly the same in the presence and absence of humic substance. Energy consumption for the treatment was around several Wh/m3. For longer operation or higher loading conditions, Fenton oxidation was effective to regenerate electrodes. Calculated results by a mathematical model developed assuming liquid film mass-transfer as a rate-limiting step were in good agreement with observed results. Based on the model, enhancement of reactor performance was discussed.

A survey of endocrine disrupting chemicals in sewage and a preliminary treatment trial

2005 ◽  
Vol 52 (8) ◽  
pp. 1-7 ◽  
Author(s):  
J.Q. Jiang ◽  
Q. Yin ◽  
P. Pearce ◽  
J. Zhou
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Sewage Treatment ◽  
Preliminary Treatment ◽  
Biological Processes ◽  
Oxidation Processes ◽  
Treatment Processes ◽  
Low Concentrations ◽  
Endocrine Disrupting ◽  
17Β Estradiol ◽  
Low Levels

This paper demonstrates that synthetic endocrine disrupting chemicals (EDCs) (e.g. bisphenol-A) and natural EDCs (e.g. estrone and 17β-estradiol) were found in the crude sewage from two sewage treatment works. Conventional biological processes can lower EDC concentrations to several hundred nanograms per litre. Because natural EDCs (e.g. estrone and 17β1-estradiol) have biological activity and an adverse impact on the environment at extremely low concentrations (several tens of nanograms per litre), and because the existing wastewater/sewage treatment processes are not adequate to reduce natural EDC concentrations lower than 100ngL−1, further treatment after conventional biological processes is required. Preliminary trials with ferrate(VI) and electrochemical oxidation processes demonstrated that the former is more effective than the latter in reducing EDC concentrations, and that both the processes can effectively reduce EDCs to very low levels, ranging between 20 and 100ngL−1.

Evaluation of reproductivity of medaka (Oryzias latipes) exposed to chemicals using a 2-week reproduction test

2000 ◽  
Vol 42 (7-8) ◽  
pp. 53-60 ◽  
Author(s):  
T. Shioda ◽  
M. Wakabayashi
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Oryzias Latipes ◽  
Test Method ◽  
Diethylhexyl Phthalate ◽  
Reproductive Ability ◽  
Tributyltin Chloride ◽  
Endocrine Disrupting ◽  
Reproduction Test ◽  
17Β Estradiol ◽  
Estrogenic Chemicals

Effects of endocrine disrupting chemicals on reproductive ability of medaka (Oryzias latipes) were investigated. Exposure of male medaka to estrogenic chemicals such as 17β-estradiol (E2), p-nonylphenol (NP), 4-t-butylphenol (BP) and bisphenol-A (BPA) caused a decrease in the numbers of eggs hatched rather than those of eggs spawned, which seemed to be affected by estrogen-like effects of these chemicals. Exposure of female medaka to E2 and NP reduced the numbers of eggs spawned rather than those of eggs hatched. The concentrations at which reproductivity of female decreased (E2:0.1 nmol/L, NP:0.03 μmu;mol/L) were lower than those of male (E2:3 nmol/L, NP:μ>0.3 μmu;mol/L). Diethylhexyl phthalate, benzophenone and tributyltin chloride did not affect reproductivity. In this study, adverse effects of estrogenic chemicals on reproductivity of medaka could be detected, so the materials and methods used in this study were considered to be able to be applied for a screening test method.

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