scholarly journals Reaction Mechanism in Aromatic Heterocyclic Compounds. III. Kinetics of the Reaction of 4-Haloquinoline 1-Oxides and Related Compounds with Piperidine.

1960 ◽  
Vol 8 (10) ◽  
pp. 892-899 ◽  
Author(s):  
Toshihiko Okamoto ◽  
Hikoya Hayatsu ◽  
Yoshihiko Baba
Keyword(s):  
Reaction Mechanism ◽  
Heterocyclic Compounds ◽  
Kinetics Of ◽  
Related Compounds ◽  
Aromatic Heterocyclic

The kinetics of hydration of tricalcium silicate

1970 ◽  
Vol 48 (21) ◽  
pp. 3291-3299 ◽  
Author(s):  
K. G. McCurdy ◽  
B. P. Erno
Keyword(s):  
Reaction Mechanism ◽  
Intermediate Product ◽  
Activation Energies ◽  
Tricalcium Silicate ◽  
Rate Data ◽  
Large Excess ◽  
First Order ◽  
Kinetics Of ◽  
Subsequent Decomposition

An investigation has been made of the kinetics of hydration of tricalcium silicate at several temperatures in a large excess of water in the presence of various added ions. The rate data have been interpreted by a reaction mechanism which involves: (a) the first order hydration of tricalcium silicate to form an intermediate product, 1.5CaO•SiO2, which can react by two pathways, (b) the direct first order decomposition of intermediate, 1.5CaO•SiO2, to form lime and silica or (b′) complexing of intermediate with silica and subsequent decomposition to form lime and silica. This reaction mechanism predicts the rate of production of base during the hydration. The effect of various added ions is interpreted in terms of the proposed mechanism.Rate constants and activation energies for the various steps in the proposed mechanism are reported.

The kinetics of the penetration of some representative anthelmintics and related compounds into Ascaris lumbricoides var. suis

Parasitology ◽  
1949 ◽  
Vol 39 (3-4) ◽  
pp. 281-290 ◽  
Author(s):  
A. R. Trim
Keyword(s):  
Ascaris Lumbricoides ◽  
Homogeneous Layer ◽  
Outermost Layer ◽  
Basic Group ◽  
Rate Of Penetration ◽  
Surface Active ◽  
Main Barrier ◽  
Kinetics Of ◽  
Related Compounds ◽  
Active Substances

1. The rate of penetration of some representative drugs into Ascaris lumbricoides var. suis has been measured.2. The series of 4-n-alkyl resorcinols shows a typical homologous series effect.3. l-Nicotine penetrates relatively slowly.4. Its rate of penetration is greatly influenced by the extent of dissociation of its methyl pyrrolidine basic group.5. The rate of penetration of nicotine is greatly accelerated in the presence of some surface active substances.6. Chloroform is the most rapidly penetrating substance studied, and its penetration is not significantly influenced by the presence of proteins, carbohydrates and fats and their products of digestion.7. An analysis of the experimental results shows that the outermost layer of the cuticle of Ascaris is probably the main barrier to penetration. It behaves as if it were a thin; homogeneous layer of lipoid.8. The significance of these results in the study of anthelmintics is assessed.

Synthesis of biologically active heterocyclic compounds from allenic and acetylenic nitriles and related compounds

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Marthe Carine Djuidje Fotsing ◽  
Dieudonné Njamen ◽  
Zacharias Tanee Fomum ◽  
Derek Tantoh Ndinteh
Keyword(s):  
Michael Addition ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Biologically Active ◽  
Polycyclic Compounds ◽  
One Step ◽  
Pharmaceutical Properties ◽  
Related Compounds ◽  
Acetylenic Acids ◽  
The Michael Addition

Abstract Cyclic and polycyclic compounds containing moieties such as imidazole, pyrazole, isoxazole, thiazoline, oxazine, indole, benzothiazole and benzoxazole benzimidazole are prized molecules because of the various pharmaceutical properties that they display. This led Prof. Landor and co-workers to engage in the synthesis of several of them such as alkylimidazolenes, oxazolines, thiazolines, pyrimidopyrimidines, pyridylpyrazoles, benzoxazines, quinolines, pyrimidobenzimidazoles and pyrimidobenzothiazolones. This review covers the synthesis of biologically active heterocyclic compounds by the Michael addition and the double Michael addition of various amines and diamines on allenic nitriles, acetylenic nitriles, hydroxyacetylenic nitriles, acetylenic acids and acetylenic aldehydes. The heterocycles were obtained in one step reaction and in most cases, did not give side products. A brief discussion on the biological activities of some heterocycles is also provided.

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