scholarly journals Design, Synthesis and Inhibitory Activities of 8-(Substituted styrol-formamido)phenyl-xanthine Derivatives on Monoamine Oxidase B

2012 ◽  
Vol 60 (3) ◽  
pp. 385-390 ◽  
Author(s):  
Suwen Hu ◽  
Siyun Nian ◽  
Kuiyou Qin ◽  
Tong Xiao ◽  
Lingna Li ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase B ◽  
Design Synthesis ◽  
Xanthine Derivatives ◽  
Inhibitory Activities

scholarly journals Design, synthesis, molecular modelling and in vitro screening of monoamine oxidase inhibitory activities of novel quinazolyl hydrazine derivatives

2020 ◽  
Vol 7 (4) ◽  
pp. 200050
Author(s):  
Adel Amer ◽  
Abdelrahman H. Hegazi ◽  
Mohammed Khalil Alshekh ◽  
Hany E. A. Ahmed ◽  
Saied M. Soliman ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Monoamine Oxidase ◽  
In Vitro Screening ◽  
Phenyl Substituent ◽  
Design Synthesis ◽  
Mao B ◽  
Mao A ◽  
Ft Ir ◽  
Inhibitory Activities

A new series of N'-substituted benzylidene-2-(4-oxo-2-phenyl-1,4-dihydroquinazolin-3(2H)-yl)acetohydrazide ( 5a–5h ) has been synthesized, characterized by FT-IR, NMR spectroscopy and mass spectrometry and tested against human monoamine oxidase (MAO) A and B. Only (4-hydroxy-3-methoxybenzylidene) substituted compounds gave submicromolar inhibition of MAO-A and MAO-B. Changing the phenyl substituent to methyl on the unsaturated quinazoline ring ( 12a–12d ) decreased inhibition, but a less flexible linker ( 14a–14d ) resulted in selective micromolar inhibition of hMAO-B providing insight for ongoing design.

Design, synthesis, biological evaluation and docking studies of sulfonyl isatin derivatives as monoamine oxidase and caspase-3 inhibitors

MedChemComm ◽  
2016 ◽  
Vol 7 (8) ◽  
pp. 1628-1639 ◽  
Author(s):  
Mohsen Tavari ◽  
Sarel F. Malan ◽  
Jacques Joubert
Keyword(s):  
Monoamine Oxidase ◽  
Caspase 3 ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Multifunctional Agents ◽  
Inhibitory Activities ◽  
Isatin Derivatives ◽  
Micromolar Range

Sulfonyl isatin derivatives as multifunctional agents showing monoamine oxidase and caspase-3 inhibitory activities in the low micromolar range.

Novel, Dual Target‐Directed Annelated Xanthine Derivatives Acting on Adenosine Receptors and Monoamine Oxidase B

ChemMedChem ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. 772-786
Author(s):  
Kamil J. Kuder ◽  
Michał Załuski ◽  
Jakub Schabikowski ◽  
Gniewomir Latacz ◽  
Agnieszka Olejarz‐Maciej ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Adenosine Receptors ◽  
Monoamine Oxidase B ◽  
Xanthine Derivatives ◽  
Dual Target

scholarly journals Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors

2016 ◽  
Vol 24 (20) ◽  
pp. 4835-4854 ◽  
Author(s):  
Ornella Di Pietro ◽  
Nelson Alencar ◽  
Gerard Esteban ◽  
Elisabet Viayna ◽  
Natalia Szałaj ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Biological Evaluation ◽  
Monoamine Oxidase B ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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