Synthesis and Biological Evaluation of Novel 9-Heteroaryl Substituted 7-Chloro-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates (TQX) as (R,S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptor Antagonists

Daniela Catarzi; Vittoria Colotta; Flavia Varano; Guido Filacchioni; Paola Gratteri; Jacopo Sgrignani; Alessandro Galli; Chiara Costagli

doi:10.1248/cpb.56.1085

Synthesis and Biological Evaluation of Novel 9-Heteroaryl Substituted 7-Chloro-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates (TQX) as (R,S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptor Antagonists

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.56.1085 ◽

2008 ◽

Vol 56 (8) ◽

pp. 1085-1091 ◽

Cited By ~ 3

Author(s):

Daniela Catarzi ◽

Vittoria Colotta ◽

Flavia Varano ◽

Guido Filacchioni ◽

Paola Gratteri ◽

...

Keyword(s):

Propionic Acid ◽

Ampa Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: Synthesis and Biological Evaluation of Novel 9-Heteroaryl Substituted 7-Chloro-4,5-dihydro-4-oxo-1,2,4-triazolo [1,5-a]quinoxaline-2-carboxylates (TQX) as (R,S)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptor Antagonists.

ChemInform ◽

10.1002/chin.200903163 ◽

2009 ◽

Vol 40 (3) ◽

Author(s):

Daniela Catarzi ◽

Vittoria Colotta ◽

Flavia Varano ◽

Guido Filacchioni ◽

Paola Gratteri ◽

...

Keyword(s):

Propionic Acid ◽

Ampa Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Synthesis And Biological Evaluation

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Synthesis and Biological Evaluation of Analogues of 7-Chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic Acid (TQX-173) as Novel Selective AMPA Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm030906q ◽

2004 ◽

Vol 47 (1) ◽

pp. 262-272 ◽

Cited By ~ 36

Author(s):

Daniela Catarzi ◽

Vittoria Colotta ◽

Flavia Varano ◽

Francesca Romana Calabri ◽

Guido Filacchioni ◽

...

Keyword(s):

Carboxylic Acid ◽

Ampa Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Synthesis And Biological Evaluation

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Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

Journal of Medicinal Chemistry ◽

10.1021/jm3007323 ◽

2012 ◽

Vol 55 (19) ◽

pp. 8211-8224 ◽

Cited By ~ 82

Author(s):

José Luis Díaz ◽

Rosa Cuberes ◽

Joana Berrocal ◽

Montserrat Contijoch ◽

Ute Christmann ◽

...

Keyword(s):

Biological Evaluation ◽

Receptor Antagonists ◽

Σ1 Receptor ◽

Synthesis And Biological Evaluation

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N-(2,7-Dimethyl-2-alkyl-2H-chromen-6-yl)sulfonamide derivatives as selective serotonin 5-HT6 receptor antagonists: design, synthesis, and biological evaluation

Journal of Molecular Structure ◽

10.1016/j.molstruc.2021.131417 ◽

2021 ◽

pp. 131417

Author(s):

Aizhan Abdildinova ◽

Young Chang Kim ◽

Gee-Hyung Lee ◽

Woo-Kyu Park ◽

Heeyeong Cho ◽

...

Keyword(s):

Biological Evaluation ◽

Selective Serotonin ◽

Receptor Antagonists ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of 4′-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.06.011 ◽

2012 ◽

Vol 20 (15) ◽

pp. 4661-4667 ◽

Cited By ~ 18

Author(s):

Renren Bai ◽

Zhen Wei ◽

Jie Liu ◽

Weijia Xie ◽

Hequan Yao ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Endothelin A Receptor ◽

Endothelin A ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of 2-(5-methyl-1H-pyrazol-1-yl) acetamide derivatives as androgen receptor antagonists

Medicinal Chemistry Research ◽

10.1007/s00044-019-02291-y ◽

2019 ◽

Vol 28 (3) ◽

pp. 380-386

Author(s):

Junze Dong ◽

Jingya Zhang ◽

Zilu Li ◽

Solomon Asnake ◽

Daoguang Zhang ◽

...

Keyword(s):

Androgen Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Androgen Receptor Antagonists

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Synthesis and Biological Evaluation of 3-Aryl-3-(4-phenoxy)-propionic Acid as a Novel Series of G Protein-Coupled Receptor 40 Agonists

Journal of Medicinal Chemistry ◽

10.1021/jm070130j ◽

2007 ◽

Vol 50 (12) ◽

pp. 2807-2817 ◽

Cited By ~ 61

Author(s):

Fengbin Song ◽

Songfeng Lu ◽

Joe Gunnet ◽

Jun Z. Xu ◽

Pam Wines ◽

...

Keyword(s):

G Protein ◽

Propionic Acid ◽

Biological Evaluation ◽

G Protein Coupled Receptor ◽

G Protein Coupled ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y1 receptor antagonists

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.09.014 ◽

2018 ◽

Vol 158 ◽

pp. 302-310 ◽

Cited By ~ 4

Author(s):

Jingjing Peng ◽

Lifen Zhao ◽

Lanlan Wang ◽

Hui Chen ◽

Yunguang Qiu ◽

...

Keyword(s):

Biological Evaluation ◽

P2y1 Receptor ◽

Receptor Antagonists ◽

Urea Derivatives ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of N-hydroxy-aminobenzyloxyarylamide analogues as novel selective κ opioid receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2020.127236 ◽

2020 ◽

Vol 30 (13) ◽

pp. 127236

Author(s):

Guangchao He ◽

Qiao Song ◽

Junwei Wang ◽

Anhua Xu ◽

Kewen Peng ◽

...

Keyword(s):

Opioid Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Opioid Receptor Antagonists ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of novel 3-oxo-4-oxa-5α-androst-17β-amide derivatives as dual 5α-reductase inhibitors and androgen receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2017.05.078 ◽

2017 ◽

Vol 27 (17) ◽

pp. 4212-4217 ◽

Cited By ~ 2

Author(s):

Kejing Lao ◽

Jie Sun ◽

Chong Wang ◽

Ying Wang ◽

Qidong You ◽

...

Keyword(s):

Androgen Receptor ◽

Biological Evaluation ◽

Receptor Antagonists ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Amide Derivatives ◽

Synthesis And Biological Evaluation ◽

Androgen Receptor Antagonists

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