scholarly journals Characterization of Dual Layered Pellets for Sustained Release of Poorly Water-Soluble Drug

2007 ◽  
Vol 55 (7) ◽  
pp. 975-979 ◽  
Author(s):  
Tae-Wan Kim ◽  
Hongkee Sah ◽  
Beom-Jin Lee
Keyword(s):  
Sustained Release ◽  
Water Soluble ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

scholarly journals DEVELOPMENT OF NATURAL AND MODIFIED GUM BASED SUSTAINED-RELEASE FILM-COATED TABLETS CONTAINING POORLY WATER-SOLUBLE DRUG

2019 ◽  
pp. 266-271
Author(s):  
AJAY KUMAR SHUKLA ◽  
RAM SINGH BISHNOI ◽  
MANISH KUMAR ◽  
C.P. JAIN
Keyword(s):  
Sustained Release ◽  
Release Rate ◽  
In Vitro Release ◽  
Release Profile ◽  
Water Soluble ◽  
The Core ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Seed Gum ◽  
Poorly Water Soluble Drug

Objective: The objective of this work was to the development of natural and modified gum based sustained-release film-coated tablets containing poorly water-soluble drug. Methods: Tamarind seed gum (TSG), fenugreek seed gum (FSG), sodium trimetaphosphate, hydroxypropyl methylcellulose (HPMC), sodium alginate (SA), and nifedipine (NFD) were used. The core tablets of nifedipine were prepared and evaluated for weight, diameters, thickness, hardness, and disintegration time. The core tablets were coated using 2% w/v solution of TSG, MTSG, FSG, and MFSG. The in vitro release rate of drug from these coated tablets was compared with the release rate of drug from the tablets coated with 2% w/v of HPMC. Results: The tablets coated with natural and modified TSG sustained the release of the drug up to 11 h and 14 h, respectively, and natural and modified FSG sustained release the drug up to 9 h and 11 h, respectively. The tablets coated with HPMC sustained released the drug up to 15 h. The drug release profile of tablets coated with modified TSG was comparable to the release profile of tablets coated with HPMC. Conclusion: On the basis of the release profile, it is concluded that unmodified and modified TSG can be used as release rate-controlling membrane.

scholarly journals Review on Polymer Based Nanoparticles for Increase the Bioavalibilty of Poorly Water Soluble Drug

2021 ◽  
pp. 56-74
Author(s):  
Karishma Mahajan ◽  
Nishant Thakur ◽  
. Simran
Keyword(s):  
Polymeric Nanoparticles ◽  
Water Soluble ◽  
Water Soluble Drug ◽  
Number Of Factors ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Review Study ◽  
And Control ◽  
Poorly Water Soluble Drug

In this review study about the polymeric nanoparticles and how polymer based nanoparticles increase bioavailability of less water soluble drugs. Polymeric nanoparticles have a matrix of biodegradable and biocompatible polymers of synthetic and natural origin. Polymer based nanoparticles are very useful for increase the solubility of the poor water-soluble drugs by decrease the particles size. Polymeric nanoparticles are very useful for targeting the drug to the specific site. Polymeric nanoparticles are also used to maintain and control the release of the drug. In present review study on the type of polymer used for the preparation of the polymer based nanoparticles. The choice of method depends on a number of factors, such as, particles size, area of application and characterization of polymeric nanoparticles.

Sign in / Sign up

Export Citation Format

Share Document