scholarly journals Identification of Novel Ligands for the Z-DNA Binding Protein by Structure-Based Virtual Screening

2007 ◽  
Vol 55 (2) ◽  
pp. 340-342 ◽  
Author(s):  
Yang-Gyun Kim ◽  
Khac-Minh Thai ◽  
Jieun Song ◽  
Kyeong Kyu Kim ◽  
Hyun-Ju Park
Keyword(s):  
Dna Binding ◽  
Virtual Screening ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Z Dna

scholarly journals Zuotin, a putative Z-DNA binding protein in Saccharomyces cerevisiae.

1992 ◽  
Vol 11 (10) ◽  
pp. 3787-3796 ◽  
Author(s):  
S. Zhang ◽  
C. Lockshin ◽  
A. Herbert ◽  
E. Winter ◽  
A. Rich
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Dna Binding ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Z Dna

scholarly journals Z-DNA Binding Protein Mediates Host Control of Toxoplasma gondii Infection

2016 ◽  
Vol 84 (10) ◽  
pp. 3063-3070 ◽  
Author(s):  
Kelly J. Pittman ◽  
Patrick W. Cervantes ◽  
Laura J. Knoll
Keyword(s):  
Immune Response ◽  
Toxoplasma Gondii ◽  
Dna Binding ◽  
Chronic Infection ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Host Immune Response ◽  
Activated Macrophages ◽  
Content Type ◽  
Z Dna

Intrinsic toToxoplasma gondiiinfection is the parasite-induced modulation of the host immune response, which ensures establishment of a chronic lifelong infection. This manipulation of the host immune response allowsT. gondiito not only dampen the ability of the host to eliminate the parasite but also trigger parasite differentiation to the slow-growing, encysted bradyzoite form. We previously used RNA sequencing (RNA-seq) to profile the transcriptomes of mice andT. gondiiduring acute and chronic stages of infection. One of the most abundant host transcripts during acute and chronic infection was Z-DNA binding protein 1 (ZBP1). In this study, we determined that ZBP1 functions to controlT. gondiigrowth. In activated macrophages isolated from ZBP1 deletion (ZBP1−/−) mice,T. gondiihas an increased rate of replication and a decreased rate of degradation. We also identified a novel function for ZBP1 as a regulator of nitric oxide (NO) production in activated macrophages, even in the absence ofT. gondiiinfection. Upon stimulation,T. gondii-infected ZBP1−/−macrophages display increased proinflammatory cytokines compared to wild-type macrophages under the same conditions. Thesein vitrophenotypes were recapitulatedin vivo, with ZBP1−/−mice having increased susceptibility to oral challenge, higher cyst burdens during chronic infection, and elevated inflammatory cytokine responses. Taken together, these results highlight a role for ZBP1 in assisting host control ofT. gondiiinfection.

5-Methylcytosine containing CG decamer as Z-DNA embedded sequence for a potential Z-DNA binding protein probe

2018 ◽  
Vol 37 (9) ◽  
pp. 485-497
Author(s):  
Vorasit Vongsutilers ◽  
Kulwadee Sawaspaiboontawee ◽  
Bodin Tuesuwan ◽  
Yoko Shinohara ◽  
Gota Kawai
Keyword(s):  
Dna Binding ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Z Dna

scholarly journals Z-DNA-Binding Protein 1 Is Critical for Controlling Virus Replication and Survival in West Nile Virus Encephalitis

2019 ◽  
Vol 10 ◽  
Author(s):  
Hussin A. Rothan ◽  
Komal Arora ◽  
Janhavi P. Natekar ◽  
Philip G. Strate ◽  
Margo A. Brinton ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Dna Binding ◽  
Virus Replication ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
West Nile ◽  
Virus Encephalitis ◽  
West Nile Virus Encephalitis ◽  
Z Dna

Energetics of Z-DNA Binding Protein-Mediated Helicity Reversals in DNA, RNA, and DNA–RNA Duplexes

2013 ◽  
Vol 117 (44) ◽  
pp. 13866-13871 ◽  
Author(s):  
Sangsu Bae ◽  
Yuyoung Kim ◽  
Doyoun Kim ◽  
Kyeong Kyu Kim ◽  
Yang-Gyun Kim ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Rna Duplexes ◽  
Z Dna ◽  
Rna And Dna

scholarly journals Z-DNA binding protein from chicken blood nuclei.

1993 ◽  
Vol 90 (8) ◽  
pp. 3339-3342 ◽  
Author(s):  
A. G. Herbert ◽  
J. R. Spitzner ◽  
K. Lowenhaupt ◽  
A. Rich
Keyword(s):  
Dna Binding ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Z Dna ◽  
Chicken Blood
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