scholarly journals A Novel Method for Predicting Disintegration Time in the Mouth of Rapidly Disintegrating Tablet by Compaction Analysis Using TabAll

2004 ◽  
Vol 52 (11) ◽  
pp. 1394-1395 ◽  
Author(s):  
Yusuke Shibata ◽  
Yoshihisa Yamamoto ◽  
Makiko Fujii ◽  
Masuo Kondoh ◽  
Yoshiteru Watanabe
Keyword(s):  
Disintegration Time ◽  
Novel Method ◽  
Rapidly Disintegrating Tablet

scholarly journals A Precise Prediction Method for the Properties of API-Containing Tablets Based on Data from Placebo Tablets

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 601
Author(s):  
Yoshihiro Hayashi ◽  
Kaede Shirotori ◽  
Atsushi Kosugi ◽  
Shungo Kumada ◽  
Kok Hoong Leong ◽  
...  
Keyword(s):  
Experimental Data ◽  
Prediction Method ◽  
Response Surfaces ◽  
Disintegration Time ◽  
Pharmaceutical Ingredients ◽  
Tablet Properties ◽  
Precise Prediction ◽  
Novel Method ◽  
Using Data ◽  
The Relationship

We previously reported a novel method for the precise prediction of tablet properties (e.g., tensile strength (TS)) using a small number of experimental data. The key technique of this method is to compensate for the lack of experimental data by using data of placebo tablets collected in a database. This study provides further technical knowledge to discuss the usefulness of this prediction method. Placebo tablets consisting of microcrystalline cellulose, lactose, and cornstarch were prepared using the design of an experimental method, and their TS and disintegration time (DT) were measured. The response surfaces representing the relationship between the formulation and the tablet properties were then created. This study investigated tablets containing four different active pharmaceutical ingredients (APIs) with a drug load ranging from 20–60%. Overall, the TS of API-containing tablets could be precisely predicted by this method, while the prediction accuracy of the DT was much lower than that of the TS. These results suggested that the mode of action of APIs on the DT was more complicated than that on the TS. Our prediction method could be valuable for the development of tablet formulations.

scholarly journals Evaluation of the Disintegration Time of Rapidly Disintegrating Tablets via a Novel Method Utilizing a CCD Camera

2002 ◽  
Vol 50 (9) ◽  
pp. 1181-1181 ◽  
Author(s):  
Yutaka Morita ◽  
Yuki Tsushima ◽  
Masanobu Yasui ◽  
Ryoji Termoz ◽  
Junko Ajioka ◽  
...  
Keyword(s):  
Ccd Camera ◽  
Disintegration Time ◽  
Novel Method

Formulation and Evaluation of Mouth Dissolving Tablets of Piroxicam

2015 ◽  
Vol 8 (3) ◽  
pp. 2941-2946
Author(s):  
Sudarshan Singh ◽  
S S Shyale ◽  
G Bhosale
Keyword(s):  
Water Solubility ◽  
Stability Study ◽  
High Porosity ◽  
Disintegration Time ◽  
Drug Content ◽  
Weight Variation ◽  
Post Operative Pain ◽  
Novel Method ◽  
Dispersion Technique

Piroxicam, a non-steroidal anti-inflammatory agent, is widely used in rheumatoid arthritis, osteoarthritis, musculo-skeletal disorders, dysmenorrhoeal and post-operative pain. It has poor bioavailability due to its inherent properties. The objective of present study is to enhance water solubility of Piroxicam by solid dispersion technique and to develop novel method of preparing compressed tablets for Piroxicam with high porosity which dissolves rapidly in mouth, using camphor as sublimating agent and super disintegrants such as Crosscarmellose sodium and sodium starch glycollate. The tablets were evaluated for hardness, thickness, friability, weight variation, wetting time, disintegration time, drug content and in vitro drug release. Optimized formulation was evaluated for stability according to ICH guideline. All tablets had hardness in range of 2.8-3.1 kg/cm2 and friability of all formulations was less than 1.0%. Weight variation and drug content were within USP limits. A stability study for optimized F6 formulation 40 °C / 75 % RH for 30 days showed little change in drug content. Therefore, it is concluded that enhance solubility and increased levels of the super disintegrants Cross carmellose sodium and sodium starch glycollate increases the rate of Piroxicam release. Camphor decreases disintegration time of tablets and create high porosity which dissolve rapidly in mouth and could be industrially feasible.

The removal and morphology of intact biofilms from implanted venous access devices

1995 ◽  
Vol 53 ◽  
pp. 1020-1021
Author(s):  
M.A. Gregory ◽  
G.P. Hadley
Keyword(s):  
Patient Selection ◽  
Surgical Oncology ◽  
Venous Access ◽  
Common Procedure ◽  
Indwelling Catheters ◽  
Careful Patient ◽  
Novel Method ◽  
The Subject ◽  
Vascular Catheters ◽  
Venous Access Devices

The insertion of implanted venous access systems for children undergoing prolonged courses of chemotherapy has become a common procedure in pediatric surgical oncology. While not permanently implanted, the devices are expected to remain functional until cure of the primary disease is assured. Despite careful patient selection and standardised insertion and access techniques, some devices fail. The most commonly encountered problems are colonisation of the device with bacteria and catheter occlusion. Both of these difficulties relate to the development of a biofilm within the port and catheter. The morphology and evolution of biofilms in indwelling vascular catheters is the subject of ongoing investigation. To date, however, such investigations have been confined to the examination of fragments of biofilm scraped or sonicated from sections of catheter. This report describes a novel method for the extraction of intact biofilms from indwelling catheters.15 children with Wilm’s tumour and who had received venous implants were studied. Catheters were removed because of infection (n=6) or electively at the end of chemotherapy.

Longitudinal Changes in Individual BrainAGE in Healthy Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

GeroPsych ◽  
2012 ◽  
Vol 25 (4) ◽  
pp. 235-245 ◽  
Author(s):  
Katja Franke ◽  
Christian Gaser
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Healthy Aging ◽  
Brain Aging ◽  
Elderly Subjects ◽  
Additional Increase ◽  
Longitudinal Changes ◽  
Novel Method ◽  
The Brain

We recently proposed a novel method that aggregates the multidimensional aging pattern across the brain to a single value. This method proved to provide stable and reliable estimates of brain aging – even across different scanners. While investigating longitudinal changes in BrainAGE in about 400 elderly subjects, we discovered that patients with Alzheimer’s disease and subjects who had converted to AD within 3 years showed accelerated brain atrophy by +6 years at baseline. An additional increase in BrainAGE accumulated to a score of about +9 years during follow-up. Accelerated brain aging was related to prospective cognitive decline and disease severity. In conclusion, the BrainAGE framework indicates discrepancies in brain aging and could thus serve as an indicator for cognitive functioning in the future.

Novel method of mitral annular enlargement for implantation of an oversized mitral valve prosthesis

2014 ◽  
Vol 62 (S 02) ◽  
Author(s):  
J. Photiadis ◽  
M. Musci ◽  
O. Miera ◽  
S. Ovroutski ◽  
A. Mekkawy ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Valve Prosthesis ◽  
Mitral Valve Prosthesis ◽  
Novel Method
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