Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors: Part I. Synthesis and Structure–Activity Relationship of 1-Alkoxymethyl-5-alkyl-6-naphthylmethyl Uracils as HEPT Analogues

Ge Meng; Fen-Er Chen; Erik De Clercq; Jan Balzarini; Christophe Pannecouque

doi:10.1248/cpb.51.779

Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors: Part I. Synthesis and Structure–Activity Relationship of 1-Alkoxymethyl-5-alkyl-6-naphthylmethyl Uracils as HEPT Analogues

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.51.779 ◽

2003 ◽

Vol 51 (7) ◽

pp. 779-789 ◽

Cited By ~ 33

Author(s):

Ge Meng ◽

Fen-Er Chen ◽

Erik De Clercq ◽

Jan Balzarini ◽

Christophe Pannecouque

Keyword(s):

Reverse Transcriptase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Relationship Of ◽

Hiv 1

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Discovery of potent HIV ‐1 non‐nucleoside reverse transcriptase inhibitors by exploring the structure–activity relationship of solvent‐exposed regions I

Chemical Biology & Drug Design ◽

10.1111/cbdd.13429 ◽

2019 ◽

Vol 93 (4) ◽

pp. 430-437 ◽

Cited By ~ 5

Author(s):

Dongwei Kang ◽

Zhao Wang ◽

Meng Chen ◽

Da Feng ◽

Gaochan Wu ◽

...

Keyword(s):

Reverse Transcriptase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Relationship Of ◽

Hiv 1

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Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors. Part 1. Synthesis and Structure—Activity Relationship of 1-Alkoxymethyl-5-alkyl-6-naphthylmethyl Uracils as HEPT Analogues.

ChemInform ◽

10.1002/chin.200350163 ◽

2003 ◽

Vol 34 (50) ◽

Author(s):

Ge Meng ◽

Fen-Er Chen ◽

Erik De Clercq ◽

Jan Balzarini ◽

Christophe Pannecouque

Keyword(s):

Reverse Transcriptase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Relationship Of ◽

Hiv 1

Download Full-text

Rational design and Structure−Activity relationship of coumarin derivatives effective on HIV-1 protease and partially on HIV-1 reverse transcriptase

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.111900 ◽

2020 ◽

Vol 186 ◽

pp. 111900 ◽

Cited By ~ 3

Author(s):

Mei Zhu ◽

Ling Ma ◽

Jiajia Wen ◽

Biao Dong ◽

Yujia Wang ◽

...

Keyword(s):

Reverse Transcriptase ◽

Rational Design ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Coumarin Derivatives ◽

Structure Activity ◽

Relationship Of ◽

Hiv 1

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Urea−PETT Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 3. Synthesis and Further Structure−Activity Relationship Studies of PETT Analogues

Journal of Medicinal Chemistry ◽

10.1021/jm990095j ◽

1999 ◽

Vol 42 (20) ◽

pp. 4150-4160 ◽

Cited By ~ 47

Author(s):

Marita Högberg ◽

Christer Sahlberg ◽

Per Engelhardt ◽

Rolf Noréen ◽

Jussi Kangasmetsä ◽

...

Keyword(s):

Reverse Transcriptase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

New Class ◽

Structure Activity ◽

Hiv 1

Download Full-text

Structure–Activity Relationship of Pyrrolyl Diketo Acid Derivatives as Dual Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

Journal of Medicinal Chemistry ◽

10.1021/jm501799k ◽

2015 ◽

Vol 58 (4) ◽

pp. 1915-1928 ◽

Cited By ~ 44

Author(s):

Giuliana Cuzzucoli Crucitti ◽

Mathieu Métifiot ◽

Luca Pescatori ◽

Antonella Messore ◽

Valentina Noemi Madia ◽

...

Keyword(s):

Reverse Transcriptase ◽

Structure Activity Relationship ◽

Ribonuclease H ◽

Activity Relationship ◽

Structure Activity ◽

Dual Inhibitors ◽

Relationship Of ◽

Hiv 1

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Docking, molecular dynamics and quantitative structure-activity relationship studies for HEPTs and DABOs as HIV-1 reverse transcriptase inhibitors

Journal of Molecular Modeling ◽

10.1007/s00894-011-1236-8 ◽

2011 ◽

Vol 18 (5) ◽

pp. 2185-2198 ◽

Cited By ~ 23

Author(s):

Yating Mao ◽

Yan Li ◽

Ming Hao ◽

Shuwei Zhang ◽

Chunzhi Ai

Keyword(s):

Molecular Dynamics ◽

Reverse Transcriptase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Hiv 1

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Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Parallel synthesis, molecular modelling and structure–activity relationship studies on O-[2-(hetero)arylethyl]-N-phenylthiocarbamates

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2007.12.050 ◽

2008 ◽

Vol 16 (7) ◽

pp. 4160-4172 ◽

Cited By ~ 10

Author(s):

Sara Cesarini ◽

Andrea Spallarossa ◽

Angelo Ranise ◽

Paola Fossa ◽

Paolo La Colla ◽

...

Keyword(s):

Reverse Transcriptase ◽

Molecular Modelling ◽

Structure Activity Relationship ◽

Parallel Synthesis ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Hiv 1

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Parallel synthesis, molecular modelling and further structure–activity relationship studies of new acylthiocarbamates as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2008.10.032 ◽

2009 ◽

Vol 44 (5) ◽

pp. 2190-2201 ◽

Cited By ~ 14

Author(s):

Andrea Spallarossa ◽

Sara Cesarini ◽

Angelo Ranise ◽

Silvia Schenone ◽

Olga Bruno ◽

...

Keyword(s):

Reverse Transcriptase ◽

Molecular Modelling ◽

Structure Activity Relationship ◽

Parallel Synthesis ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Hiv 1

Download Full-text

Urea−PETT Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 3. Synthesis and Further Structure−Activity Relationship Studies of PETT Analogues.

Journal of Medicinal Chemistry ◽

10.1021/jm990572y ◽

2000 ◽

Vol 43 (2) ◽

pp. 304-304 ◽

Cited By ~ 7

Author(s):

Marita Högberg ◽

Christer Sahlberg ◽

Per Engelhardt ◽

Rolf Noréen ◽

Jussi Kangasmetsä ◽

...

Keyword(s):

Reverse Transcriptase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Reverse Transcriptase Inhibitors ◽

New Class ◽

Structure Activity ◽

Hiv 1

Download Full-text

Quantitative Structure-Activity Relationship Study of 2-arylsulfonyl-6-substituted Benzonitriles as Non-nucleoside Reverse Transcriptase Inhibitors of HIV-1

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.1080/1475636021000010932 ◽

2002 ◽

Vol 17 (4) ◽

pp. 219-225 ◽

Cited By ~ 2

Author(s):

B.K. Sharma ◽

Rajendra Kumar ◽

P. Singh

Keyword(s):

Reverse Transcriptase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Structure Activity ◽

Relationship Study ◽

Hiv 1

Download Full-text