scholarly journals New Triterpene Aldehydes, Lucialdehydes A—C, from Ganoderma lucidum and Their Cytotoxicity against Murine and Human Tumor Cells

2002 ◽  
Vol 50 (6) ◽  
pp. 837-840 ◽  
Author(s):  
Jiang-Jing Gao ◽  
Byung-Sun Min ◽  
Eun-Mi Ahn ◽  
Norio Nakamura ◽  
Hyeong-Kyu Lee ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Ganoderma Lucidum ◽  
Human Tumor ◽  
Human Tumor Cells

Inhibitor or promoter? The performance of polysaccharides from Ganoderma lucidum on human tumor cells with different p53 statuses

2016 ◽  
Vol 7 (4) ◽  
pp. 1872-1875 ◽  
Author(s):  
Jue Zhang ◽  
Jun-ming Chen ◽  
Xiao-xia Wang ◽  
Yong-mei Xia ◽  
Steve W. Cui ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Ganoderma Lucidum ◽  
Human Tumor ◽  
Tumor Suppressor Protein ◽  
Human Tumor Cells ◽  
Cancer Cell Growth ◽  
Tumor Suppressor Protein P53

GLPs inhibit cancer cell growth when the tumor suppressor protein p53 is functional but often stimulate cancer cells when p53 is absent.

ChemInform Abstract: New Triterpene Aldehydes, Lucialdehydes A-C, from Ganoderma lucidum and Their Cytotoxicity Against Murine and Human Tumor Cells.

ChemInform ◽  
2010 ◽  
Vol 33 (48) ◽  
pp. no-no ◽  
Author(s):  
Jiang-Jing Gao ◽  
Byung-Sun Min ◽  
Eun-Mi Ahn ◽  
Norio Nakamura ◽  
Hyeong-Kyu Lee ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Ganoderma Lucidum ◽  
Human Tumor ◽  
Human Tumor Cells

Inhibition by dihydrorifampicin of RNA polymerases I and II isolated from nuclei of Rous sarcoma cells and human tumor cells HEp-2

1979 ◽  
Vol 44 (9) ◽  
pp. 2722-2736 ◽  
Author(s):  
Jindřich Kára ◽  
Zdeněk Hostomský
Keyword(s):  
Tumor Cells ◽  
Human Tumor ◽  
Tumor Cell Line ◽  
Selective Inhibition ◽  
Rna Polymerases ◽  
Embryonic Cells ◽  
Human Tumor Cells ◽  
Ribonucleic Acids ◽  
Rous Sarcoma ◽  
Sarcoma Cells

Dihydrorifampicin, a rifampicin derivative hydrogenated at the 18-19 carbon atoms of the aliphatic ansa chain of the rifampicin molecule, inhibits the enzymatic activity of RNA polymerases I and II, isolated from the nuclei of avian tumor cells (Rous sarcoma) and from the human tumor cell line HEp-2. The RNA polymerases from these tumors have been separated and partially purified by chromatography on DEAE Sephadex A-25 and characterized by the sensitivity to α-amanitin. The [3H]UMP-labeled ribonucleic acids synthesized in the isolated nuclei of Rous sarcoma cells in the presence and absence of DHR were analyzed by sedimentation analysis in sucrose density gradients. It was found that the synthesis of rRNAs and mRNAs is very significantly inhibited by dihydrorifampicin, whereas the synthesis of tRNAs is much less inhibited at the same DHR concentration (100μg/ml). The observed cytostatic effect of DHR on the growth of human tumor cells HEp-2 and embryonic cells in culture is apparently mediated by the selective inhibition of RNA polymerases I and II in human and avian cells. The relationship between the molecular structure of DHR and its affinity to RNA polymerases of eukaryotic cells is discussed.

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