Constituents of the Pollen of Crocus sativus L. and Their Tyrosinase Inhibitory Activity

Background: Reactive oxygen species and reactive nitrogen species, which are collectively called reactive oxygen nitrogen species, are inevitable by-products of cellular metabolic redox reactions, such as oxidative phosphorylation in the mitochondrial respiratory chain, phagocytosis, reactions of biotransformation of exogenous and endogenous substrata in endoplasmic reticulum, eicosanoid synthesis, and redox reactions in the presence of metal with variable valence. Among medicinal plants there is a growing interest in Crocus sativus L. It is a perennial, stemless herb, belonging to Iridaceae family, cultivated in various countries such as Greece, Italy, Spain, Israel, Morocco, Turkey, Iran, India, China, Egypt and Mexico. Objective: The present study aims to address the anti-toxicant role of Crocus sativus L. in the cases of toxin and drug toxification. Materials and Methods: An electronic literature search was conducted by the two authors from 1993 to August 2017. Original articles and systematic reviews (with or without meta-analysis), as well as case reports were selected. Titles and abstracts of papers were screened by a third reviewer to determine whether they met the eligibility criteria, and full texts of the selected articles were retrieved. Results: The authors focused on literature concerning the role of Crocus Sativus L. as an anti-toxicant agent. Literature review showed that Saffron is a potent anti-toxicant agent with a plethora of applications ranging from anti-oxidant properties, to chemotherapy protective effects. Conclusion: Literature findings represented in current review herald promising results for using Crocus Sativus L. and/or its active constituents as anti-toxicant, chemotherapy-induced protection and toxin protection.

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Patents on Therapeutic and Cosmetic Applications of Bioactives of Crocus Sativus L. and their Production through Synthetic Biology Methods: A Review

Recent Patents on Biotechnology ◽

10.2174/1872210510666161114123804 ◽

2017 ◽

Vol 11 (1) ◽

pp. 3-19 ◽

Cited By ~ 2

Author(s):

Manasi Telang ◽

Mitali Dawalbhakta

Keyword(s):

Synthetic Biology ◽

Crocus Sativus ◽

Crocus Sativus L

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Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers

Food and Chemical Toxicology ◽

10.1016/j.fct.2019.05.013 ◽

2019 ◽

Vol 130 ◽

pp. 32-43 ◽

Cited By ~ 2

Author(s):

Elias Begas ◽

Maria Bounitsi ◽

Thomas Kilindris ◽

Evangelos Kouvaras ◽

Konstantinos Makaritsis ◽

...

Keyword(s):

Healthy Volunteers ◽

Crocus Sativus ◽

Short Term ◽

Metabolizing Enzymes ◽

Xenobiotic Metabolizing Enzymes ◽

Crocus Sativus L

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