scholarly journals Co2(CO)8-mediated Endo Mode Cyclization of Epoxy-alcohol: Synthesis of 2-Ethynyl-3-hydroxy-2-methyltetrahydropyran and 2-Ethynyl-3-hydroxy-3-methyltetrahydropyran Derivatives.

2001 ◽  
Vol 49 (5) ◽  
pp. 613-618 ◽  
Author(s):  
Chisato MUKAI ◽  
Sumie YAMAGUCHI ◽  
In Jong KIM ◽  
Miyoji HANAOKA
Keyword(s):  
Epoxy Alcohol ◽  
Alcohol Synthesis

ChemInform Abstract: An Enantioselective Construction of a Tetrahydrofuran Synthon via an Epoxy Alcohol: Synthesis of the (S)-Enantiomer of SRI- 62-834.

ChemInform ◽  
2010 ◽  
Vol 27 (30) ◽  
pp. no-no
Author(s):  
K. PRASAD ◽  
W. J. HOULIHAN ◽  
C.-P. CHEN ◽  
R. L. UNDERWOOD ◽  
O. REPIC
Keyword(s):  
Epoxy Alcohol ◽  
Alcohol Synthesis

Direct epoxy alcohol synthesis from cyclic olefins using molecular oxygen and VO(acac)2-AIBN catalyst system

1980 ◽  
Vol 45 (15) ◽  
pp. 3004-3009 ◽  
Author(s):  
Kiyotomi Kaneda ◽  
Koichiro Jitsukawa ◽  
Takashi Itoh ◽  
Shiichiro Teranishi
Keyword(s):  
Molecular Oxygen ◽  
Catalyst System ◽  
Epoxy Alcohol ◽  
Cyclic Olefins ◽  
Alcohol Synthesis

An enantioselective construction of a tetrahydrofuran synthon via an epoxy alcohol: Synthesis of S-enantiomer of SRI 62-834

1996 ◽  
Vol 7 (3) ◽  
pp. 837-842 ◽  
Author(s):  
Kapa Prasad ◽  
William J. Houlihan ◽  
Chung-Pin Chen ◽  
Russell L. Underwood ◽  
Oljan Repic
Keyword(s):  
Epoxy Alcohol ◽  
Alcohol Synthesis

Cryogels based on composition chitosan–polyvinyl alcohol: synthesis and properties

2019 ◽  
Vol 5 (4) ◽  
pp. 56-63
Author(s):  
E.V. Dikhtiaruk ◽  
◽  
V.V. Paientko ◽  
A.K. Matkovsky ◽  
Yu.N. Nichiporuk ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Alcohol Synthesis

scholarly journals Lipid Metabolic Events Underlying the Formation of the Corneocyte Lipid Envelope

2021 ◽  
pp. 1-13
Author(s):  
Philip W. Wertz
Keyword(s):  
Stratum Corneum ◽  
Outer Surface ◽  
Barrier Function ◽  
Skin Surface ◽  
Schiff’S Base ◽  
Cornified Envelope ◽  
Epoxy Alcohol ◽  
Viable Epidermis ◽  
Transglutaminase 1 ◽  
Base Formation

Cornified cells of the stratum corneum have a monolayer of an unusual lipid covalently attached to the outer surface. This is referred to as the corneocyte lipid envelope (CLE). It consists of a monolayer of ω-hydroxyceramides covalently attached to the outer surface of the cornified envelope. The CLE is essential for proper barrier function of the skin and is derived from linoleate-rich acylglucosylceramides synthesized in the viable epidermis. Biosynthesis of acylglucosylceramide and its conversion to the cornified envelope is complex. Acylglucosylceramide in the bounding membrane of the lamellar granule is the precursor of the CLE. The acylglucosylceramide in the limiting membrane of the lamellar granule may be oriented with the glucosyl moiety on the inside. Conversion of the acylglucosylceramide to the CLE requires removal of the glucose by action of a glucocerebrosidase. The ester-linked fatty acid may be removed by an as yet unidentified esterase, and the resulting ω-hydroxyceramide may become ester linked to the outer surface of the cornified envelope through action of transglutaminase 1. Prior to removal of ester-linked fatty acids, linoleate is oxidized to an epoxy alcohol through action of 2 lipoxygenases. This can be further oxidized to an epoxy-enone, which can spontaneously attach to the cornified envelope through Schiff’s base formation. Mutations of genes coding for enzymes involved in biosynthesis of the CLE result in ichthyosis, often accompanied by neurologic dysfunction. The CLE is recognized as essential for barrier function of skin, but many questions about details of this essentiality remain. What are the relative roles of the 2 mechanisms of lipid attachment? What is the orientation of acylglucosylceramide in the bounding membrane of lamellar granules? Some evidence supports a role for CLE as a scaffold upon which intercellular lamellae unfold, but other evidence does not support this role. There is also controversial evidence for a role in stratum corneum cohesion. Evidence is presented to suggest that covalently bound ω-hydroxyceramides serve as a reservoir for free sphingosine that can serve in communicating with the viable epidermis and act as a potent broad-acting antimicrobial at the skin surface. Many questions remain.

scholarly journals Allylic Alcohol Synthesis by Ni-Catalyzed Direct and Selective Coupling of Alkynes and Methanol

2021 ◽  
Author(s):  
Herong chen ◽  
Zhijun Zhou ◽  
Wangqing Kong
Keyword(s):  
Coupling Reaction ◽  
Allylic Alcohol ◽  
Raw Material ◽  
Alcohol Synthesis

Methanol is an abundant and renewable chemical raw material, but its use as a C1 source in C-C bond coupling reaction still constitutes a big challenge, and the known methods...

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