Highly Potent and Orally Active Non-Peptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 4'-[(4,4-Difluoro-5-methylidene-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl)carbonyl]-2-phenylbenzanililde Derivatives.

Yoshiaki SHIMADA; Nobuaki TANIGUCHI; Akira MATSUHISA; Kenichiro SAKAMOTO; Takeyuki YATSU; Akihiro TANAKA

doi:10.1248/cpb.48.1644

Highly Potent and Orally Active Non-Peptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 4'-[(4,4-Difluoro-5-methylidene-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl)carbonyl]-2-phenylbenzanililde Derivatives.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.48.1644 ◽

2000 ◽

Vol 48 (11) ◽

pp. 1644-1651 ◽

Cited By ~ 29

Author(s):

Yoshiaki SHIMADA ◽

Nobuaki TANIGUCHI ◽

Akira MATSUHISA ◽

Kenichiro SAKAMOTO ◽

Takeyuki YATSU ◽

...

Keyword(s):

Arginine Vasopressin ◽

Pharmacological Properties ◽

Vasopressin Antagonists ◽

Orally Active

Download Full-text

ChemInform Abstract: Highly Potent and Orally Active Non-peptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 4′-[(4,4-Difluoro-5-methylidene-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl )carbonyl

ChemInform ◽

10.1002/chin.200116165 ◽

2001 ◽

Vol 32 (16) ◽

pp. no-no

Author(s):

Yoshiaki Shimada ◽

Nobuaki Taniguchi ◽

Akira Matsuhisa ◽

Kenichiro Sakamoto ◽

Takeyuki Yatsu ◽

...

Keyword(s):

Arginine Vasopressin ◽

Pharmacological Properties ◽

Vasopressin Antagonists ◽

Orally Active

Download Full-text

Nonpeptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 4'-(5-(Substituted Methylidene)-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)benzanilide and 4'-(5-(Substituted Methyl)-2,3-dihydro-1H-1-benzoazepine-1-carbonyl)benzanilide Derivatives.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.47.329 ◽

1999 ◽

Vol 47 (3) ◽

pp. 329-339 ◽

Cited By ~ 15

Author(s):

Akira MATSUHISA ◽

Kazumi KIKUCHI ◽

Kenichiro SAKAMOTO ◽

Takeyuki YATSU ◽

Akihiro TANAKA

Keyword(s):

Arginine Vasopressin ◽

Pharmacological Properties ◽

Vasopressin Antagonists

Download Full-text

Nonpeptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 2-Phenyl-4'-(2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-carbonyl)benzanilide Derivatives.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.46.1566 ◽

1998 ◽

Vol 46 (10) ◽

pp. 1566-1579 ◽

Cited By ~ 22

Author(s):

Akira MATSUHISA ◽

Hiroyuki KOSHIO ◽

Kenichiro SAKAMOTO ◽

Nobuaki TANIGUCHI ◽

Takeyuki YATSU ◽

...

Keyword(s):

Arginine Vasopressin ◽

Pharmacological Properties ◽

Vasopressin Antagonists

Download Full-text

ChemInform Abstract: Nonpeptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 2-Phenyl-4′- [(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]benzanilide Derivatives (I)

ChemInform ◽

10.1002/chin.199818184 ◽

2010 ◽

Vol 29 (18) ◽

pp. no-no

Author(s):

A. MATSUHISA ◽

A. TANAKA ◽

K. KIKUCHI ◽

Y. SHIMADA ◽

T. YATSU ◽

...

Keyword(s):

Arginine Vasopressin ◽

Pharmacological Properties ◽

Vasopressin Antagonists

Download Full-text

Nonpeptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 2-Phenyl-4'-((2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl)benzanilide Derivatives.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.45.1870 ◽

1997 ◽

Vol 45 (11) ◽

pp. 1870-1874 ◽

Cited By ~ 18

Author(s):

Akira MATSUHISA ◽

Akihiro TANAKA ◽

Kazumi KIKUCHI ◽

Yoshiaki SHIMADA ◽

Takeyuki YATSU ◽

...

Keyword(s):

Arginine Vasopressin ◽

Pharmacological Properties ◽

Vasopressin Antagonists

Download Full-text

ChemInform Abstract: Nonpeptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 4′-(1,4,5,6-Tetrahydroimidazo[4,5-d] [1]benzoazepine-6-carbonyl)benzanilide Derivatives and 4′-(5,6-Dihydro-4H-thia

ChemInform ◽

10.1002/chin.200026157 ◽

2010 ◽

Vol 31 (26) ◽

pp. no-no

Author(s):

Akira Matsuhisa ◽

Nobuaki Taniguchi ◽

Hiroyuki Koshio ◽

Takeyuki Yatsu ◽

Akihiro Tanaka

Keyword(s):

Arginine Vasopressin ◽

Pharmacological Properties ◽

Vasopressin Antagonists

Download Full-text

Nonpeptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 4'-(1,4,5,6-Tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl)benzanilide Derivatives and 4'-(5,6-Dihydro-4H-thiazolo[5,4-d][1]benzoazepine-6-carbonyl)benzanilide Derivatives.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.48.21 ◽

2000 ◽

Vol 48 (1) ◽

pp. 21-31 ◽

Cited By ~ 26

Author(s):

Akira MATSUHISA ◽

Nobuaki TANIGUCHI ◽

Hiroyuki KOSHIO ◽

Takeyuki YATSU ◽

Akihiro TANAKA

Keyword(s):

Arginine Vasopressin ◽

Pharmacological Properties ◽

Vasopressin Antagonists

Download Full-text

ChemInform Abstract: Nonpeptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 4′-[5-(Substituted Methylidene)-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl]benzanilide and 4′-[5-(Substituted M

ChemInform ◽

10.1002/chin.199942283 ◽

2010 ◽

Vol 30 (42) ◽

pp. no-no

Author(s):

Akira Matsuhisa ◽

Kazumi Kikuchi ◽

Kenichiro Sakamoto ◽

Takeyuki Yatsu ◽

Akihiro Tanaka

Keyword(s):

Arginine Vasopressin ◽

Pharmacological Properties ◽

Vasopressin Antagonists

Download Full-text

ChemInform Abstract: Nonpeptide Arginine Vasopressin Antagonists for Both V1A and V2 Receptors: Synthesis and Pharmacological Properties of 2-Phenyl-4′- (2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-carbonyl)benzanilide Derivatives.

ChemInform ◽

10.1002/chin.199915186 ◽

2010 ◽

Vol 30 (15) ◽

pp. no-no

Author(s):

Akira Matsuhisa ◽

Hiroyuki Koshio ◽

Kenichiro Sakamoto ◽

Nobuaki Taniguchi ◽

Takeyuki Yatsu ◽

...

Keyword(s):

Arginine Vasopressin ◽

Pharmacological Properties ◽

Vasopressin Antagonists

Download Full-text

Non-peptide arginine-vasopressin antagonists: the vaptans

The Lancet ◽

10.1016/s0140-6736(08)60695-9 ◽

2008 ◽

Vol 371 (9624) ◽

pp. 1624-1632 ◽

Cited By ~ 253

Author(s):

Guy Decaux ◽

Alain Soupart ◽

Gilbert Vassart

Keyword(s):

Arginine Vasopressin ◽

Vasopressin Antagonists

Download Full-text