scholarly journals A Collagen Network Formation Effector from Leaves of Premna subscandens.

1999 ◽  
Vol 47 (9) ◽  
pp. 1341-1343 ◽  
Author(s):  
Hirokazu SUDO ◽  
Kaori KIJIMA(nee YUASA) ◽  
Hideaki OTSUKA ◽  
Toshinori IDE ◽  
Eiji HIRATA ◽  
...  
Keyword(s):  
Network Formation ◽  
Collagen Network

scholarly journals A36 MODULATION OF COLLAGEN NETWORK FORMATION TO IMPROVE FUNCTIONAL PROPERTIES IN CARTILAGE REGENERATION

2006 ◽  
Vol 14 ◽  
pp. S35
Author(s):  
Y.M. Jenniskens ◽  
W. Koevoet ◽  
A.C. De Bart ◽  
J.A. Verhaar ◽  
H. Weinans ◽  
...  
Keyword(s):  
Functional Properties ◽  
Network Formation ◽  
Cartilage Regeneration ◽  
Collagen Network

Complexity of type IV collagens: from network assembly to function

2019 ◽  
Vol 400 (5) ◽  
pp. 565-574 ◽  
Author(s):  
Yuexin Wu ◽  
Gaoxiang Ge
Keyword(s):  
Type Iv Collagen ◽  
Network Formation ◽  
Basement Membranes ◽  
Structural Components ◽  
Collagen Network ◽  
Complex Type ◽  
Form Complex ◽  
Structural Support ◽  
Type Iv ◽  
Covalent Crosslinking

Abstract Collagens form complex networks in the extracellular space that provide structural support and signaling cues to cells. Network-forming type IV collagens are the key structural components of basement membranes. In this review, we discuss how the complexity of type IV collagen networks is established, focusing on collagen α chain selection in type IV collagen protomer and network formation; covalent crosslinking in type IV collagen network stabilization; and the differences between solid-state type IV collagen in the extracellular matrix and soluble type IV collagen fragments. We further discuss how complex type IV collagen networks exert their physiological and pathological functions through cell surface integrin and nonintegrin receptors.

Inhibition of glycosaminoglycan incorporation influences collagen network formation during cartilage matrix production

2009 ◽  
Vol 379 (2) ◽  
pp. 222-226 ◽  
Author(s):  
Yvonne M. Bastiaansen-Jenniskens ◽  
Wendy Koevoet ◽  
Kaspar M.B. Jansen ◽  
Jan A.N. Verhaar ◽  
Jeroen DeGroot ◽  
...  
Keyword(s):  
Network Formation ◽  
Cartilage Matrix ◽  
Collagen Network ◽  
Matrix Production

ChemInform Abstract: A Collagen Network Formation Effector from Leaves of Premna subscandens.

ChemInform ◽  
2010 ◽  
Vol 31 (11) ◽  
pp. no-no
Author(s):  
Hirokazu Sudo ◽  
Kaori Kijima ◽  
Hideaki Otsuka ◽  
Toshinori Ide ◽  
Eiji Hirata ◽  
...  
Keyword(s):  
Network Formation ◽  
Collagen Network

scholarly journals A21 INHIBITION OF PROTEOGLYCAN PRODUCTION INFLUENCES CARTILAGE COLLAGEN NETWORK FORMATION

2008 ◽  
Vol 16 ◽  
pp. S22
Author(s):  
Y.M. Bastiaansen-Jenniskens ◽  
W. Koevoet ◽  
K.M. Jansen ◽  
J.A. Verhaar ◽  
J. DeGroot ◽  
...  
Keyword(s):  
Network Formation ◽  
Collagen Network

Platelet Microtubules in Clot Structure Formation and Contractile Force Generation: Investigation of a Controversy

1986 ◽  
Vol 56 (01) ◽  
pp. 023-027 ◽  
Author(s):  
C J Jen ◽  
L V McIntire
Keyword(s):  
Network Formation ◽  
Contractile Force ◽  
Second Phase ◽  
Clot Retraction ◽  
Forming Process ◽  
Microtubule Organization ◽  
Physiological Processes ◽  
Fibrin Network ◽  
Two Parameters

SummaryWhether platelet microtubules are involved in clot retraction/ contraction has been controversial. To address this question we have simultaneously measured two clotting parameters, clot structural rigidity and isometric contractile force, using a rheological technique. For recalcified PRP clots these two parameters began rising together at about 15 min after CaCl2 addition. In the concentration range affecting microtubule organization in platelets, colchicine, vinca alkaloids and taxol demonstrated insignificant effects on both clotting parameters of a recalcified PRP clot. For PRP clots induced by adding small amounts of exogenous thrombin, the kinetic curves of clot rigidity were biphasic and without a lag time. The first phase corresponded to a platelet-independent network forming process, while the second phase corresponded to a platelet-dependent process. These PRP clots began generating contractile force at the onset of the second phase. For both rigidity and force parameters, only the second phase of clotting kinetics was retarded by microtubule affecting reagents. When PRP samples were clotted by adding a mixture of CaCl2 and thrombin, the second phase clotting was accelerated and became superimposed on the first phase. The inhibitory effects of micro tubule affecting reagents became less pronounced. Thrombin clotting of a two-component system (washed platelets/ purified fibrinogen) was also biphasic, with the second phase being microtubule-dependent. In conclusion, platelet microtubules are important in PRP clotted with low concentrations of thrombin, during which fibrin network formation precedes platelet-fibrin interactions. On the other hand they are unimportant if a PRP clot is induced by recalcification, during which the fibrin network is constructed in the presence of platelet-fibrin interactions. The latter is likely to be more analogous to physiological processes in vivo.

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