scholarly journals Phyridonecarboxylic Acids as Antibacterial Agents. Part XX. 7-(2-Aminomethyl-1-azetidinyl)-4-oxoquinoline-3-carboxylic Acids as Potent Antibacterial Agents: Design, Synthesis, and Antibacterial Activity.

1998 ◽  
Vol 46 (5) ◽  
pp. 787-796 ◽  
Author(s):  
Masahiro FUJITA ◽  
Katsumi CHIBA ◽  
Yukio TOMINAGA ◽  
Katsuhiko HINO
Keyword(s):  
Antibacterial Activity ◽  
Carboxylic Acids ◽  
Antibacterial Agents ◽  
Design Synthesis

Design, synthesis and biological evaluation of 5′-C-piperidinyl-5′-O-aminoribosyluridines as potential antibacterial agents

2015 ◽  
Vol 13 (28) ◽  
pp. 7720-7735 ◽  
Author(s):  
Takeshi Nakaya ◽  
Akira Matsuda ◽  
Satoshi Ichikawa
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Human Cells ◽  
Ritter Reaction ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Caprazamycin analogues, which were designed and synthesized via an aza-Prins–Ritter reaction, exhibit a good MraY and antibacterial activity without cytotoxicity against human cells.

Design, synthesis and mode of action of some benzothiazole derivatives bearing an amide moiety as antibacterial agents

RSC Advances ◽  
2014 ◽  
Vol 4 (36) ◽  
pp. 19013-19023 ◽  
Author(s):  
Meenakshi Singh ◽  
Sudhir K. Singh ◽  
Mayank Gangwar ◽  
Gopal Nath ◽  
Sushil K. Singh
Keyword(s):  
Antibacterial Activity ◽  
Mode Of Action ◽  
Antibacterial Agents ◽  
Design Synthesis ◽  
Benzothiazole Derivatives

Schematic outline of the most potent compound, benzothiazole bearing amide moiety A07, showing antibacterial activity and its mode of action.

scholarly journals Design, synthesis and antibacterial activity of new phthalazinedione derivatives

2011 ◽  
Vol 76 (3) ◽  
pp. 329-339 ◽  
Author(s):  
El-Galil Khalil ◽  
Moged Berghot ◽  
Mostafa Gouda
Keyword(s):  
Antibacterial Activity ◽  
Sodium Hydroxide ◽  
Ring Opening ◽  
Antibacterial Agents ◽  
Acetyl Chloride ◽  
Triazole Derivative ◽  
Design Synthesis ◽  
Gewald Reaction ◽  
Triazine Derivatives ◽  
Thiophene Derivatives

Dibenzobarrelene (1) was utilized as the key intermediate for the synthesis of some new 2-substituted (1,4-dioxo-3,4,4e,5,10,10ahexahydro- 1H-5,10-benzeno-benzo[g]phthalazine: 2, 5a-d, 8a-c and 10. Condensation of 2 with benzaldehyde or anisaldehyde gave the corresponding acrylonitrile derivative 3a, b, respectively. Thiophene derivatives 4a, b were obtained via the Gewald reaction of 2 with cyclohexanone or pentanone, respectively. Treatment of 5d with acetyl chloride or p-toluenesulfonyl chloride afforded the corresponding esters 6, 7, respectively. Cyclization of 8a-c with formalin afforded the corresponding triazine derivatives 9a-c. Ring opening of 10 with sodium hydroxide gave the corresponding triazole derivative 11, which when alkylated with pentyl bromide afforded the pentylsulfanyl derivative 12. Representative compounds of the synthesized products were established and evaluated as antibacterial agents.

scholarly journals Pyridonecarboxylic acid antibacterial agents. Part XV. Synthesis of 7-thio-substituted 4-oxoquinoline-3-carboxylic acids with antibacterial activity.

1990 ◽  
Vol 38 (8) ◽  
pp. 2190-2196 ◽  
Author(s):  
Yoshiro NISHIMURA ◽  
Tohru HIROSE ◽  
Hidetsugu OKADA ◽  
Koh-ichiro SHIBAMORI ◽  
Junji NAKANO ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Carboxylic Acids ◽  
Antibacterial Agents

scholarly journals Design, synthesis and evaluation of anti-inflammatory, analgesic and antibacterial activity of 2, 4, 6-trisubstituted quinazoline derivatives

2018 ◽  
Vol 29 (2) ◽  
pp. 97-102
Author(s):  
Nivrati Jain ◽  
Harshita Jain ◽  
Ashish Jain ◽  
Veerasamy Ravichandran ◽  
Prateek Jain
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Spectroscopy Analysis ◽  
Design Synthesis ◽  
E Coli ◽  
Quinazoline Derivatives ◽  
Anti Inflammatory ◽  
Synthesis And Biological Evaluation ◽  
Mass Spectroscopy Analysis

Abstract We described here the synthesis and biological evaluation of a series of 2, 4, 6-trisubstituted quinazoline derivatives as potential anti-inflammatory, analgesic and antibacterial agents. The synthesized compounds were characterized by FTIR, 1H NMR and mass spectroscopy analysis. We found that the compounds 6b, 6e, 6g, 6h and 6j showed better anti-inflammatory activity than indomethacin. Compounds 6b, 6e, 6h, 6j and 6l were found to exhibit appreciable analgesic activity, and 6b, 6g and 6k showed good antibacterial activity against Gram (+) bacteria: B. subtilis, S. aureus, S. epidermis, and Gram (-) bacteria: E. coli, P. aeruginosa and K. pneumoniae. Compound 6b showed overall better anti-inflammatory, analgesic and antibacterial activity among the synthesized compounds. The results of the present study could be helpful for the designing of effective anti-inflammatory, analgesic and antibacterial agents.

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