A 3D-Quantitative Structur-Activity Relationship Study of Benzamide Type Serotonin 5-HT4 Receptor Agonists Based on a Comparative Molecular Field Analysis Model, and the Design and Synthesis of Potent Agonists.

Takuji KAKIGAMI; Nobuaki TSURUTA; Katsura TSUKAMOTO; Toshinao USUI; Takao IKAMI

doi:10.1248/cpb.46.1881

A 3D-Quantitative Structur-Activity Relationship Study of Benzamide Type Serotonin 5-HT4 Receptor Agonists Based on a Comparative Molecular Field Analysis Model, and the Design and Synthesis of Potent Agonists.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.46.1881 ◽

1998 ◽

Vol 46 (12) ◽

pp. 1881-1886

Author(s):

Takuji KAKIGAMI ◽

Nobuaki TSURUTA ◽

Katsura TSUKAMOTO ◽

Toshinao USUI ◽

Takao IKAMI

Keyword(s):

Field Analysis ◽

Molecular Field ◽

Activity Relationship ◽

Comparative Molecular Field Analysis ◽

Analysis Model ◽

Receptor Agonists ◽

Design And Synthesis ◽

Molecular Field Analysis ◽

Relationship Study

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Comparative molecular field analysis of selective A3 adenosine receptor agonists

Bioorganic & Medicinal Chemistry ◽

10.1016/0968-0896(95)00116-x ◽

1995 ◽

Vol 3 (10) ◽

pp. 1331-1343 ◽

Cited By ~ 14

Author(s):

Suhaib M. Siddiqi ◽

Robert A. Pearlstein ◽

Lawrence H. Sanders ◽

Kenneth A. Jacobson

Keyword(s):

Adenosine Receptor ◽

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Adenosine Receptor Agonists ◽

Receptor Agonists ◽

Molecular Field Analysis ◽

A3 Adenosine Receptor

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Three-Dimensional Quantitative Structure-Activity Relationship Studies on UGT1A9-Mediated 3-O-Glucuronidation of Natural Flavonols Using a Pharmacophore-Based Comparative Molecular Field Analysis Model

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.110.175356 ◽

2010 ◽

Vol 336 (2) ◽

pp. 403-413 ◽

Cited By ~ 31

Author(s):

Baojian Wu ◽

John Kenneth Morrow ◽

Rashim Singh ◽

Shuxing Zhang ◽

Ming Hu

Keyword(s):

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Field Analysis ◽

Molecular Field ◽

Activity Relationship ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

Analysis Model ◽

Structure Activity

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Diltiazem-like Calcium Entry Blockers: A Hypothesis of the Receptor-Binding Site Based on a Comparative Molecular Field Analysis Model

Journal of Medicinal Chemistry ◽

10.1021/jm9605647 ◽

1997 ◽

Vol 40 (1) ◽

pp. 125-131 ◽

Cited By ~ 21

Author(s):

Federico Corelli ◽

Fabrizio Manetti ◽

Andrea Tafi ◽

Giuseppe Campiani ◽

Vito Nacci ◽

...

Keyword(s):

Binding Site ◽

Receptor Binding ◽

Calcium Entry ◽

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Analysis Model ◽

Calcium Entry Blockers ◽

Receptor Binding Site ◽

Molecular Field Analysis

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Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective β2-adrenergic receptor agonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.11.062 ◽

2010 ◽

Vol 18 (2) ◽

pp. 728-736 ◽

Cited By ~ 36

Author(s):

Krzysztof Jozwiak ◽

Anthony Yiu-Ho Woo ◽

Mary J. Tanga ◽

Lawrence Toll ◽

Lucita Jimenez ◽

...

Keyword(s):

Adrenergic Receptor ◽

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Receptor Agonists ◽

Molecular Field Analysis ◽

Β2 Adrenergic Receptor

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Three-Dimensional Quantitative Structure−Activity Relationship Study of the Cannabimimetic (Aminoalkyl)indoles Using Comparative Molecular Field Analysis

Journal of Medicinal Chemistry ◽

10.1021/jm980305c ◽

1998 ◽

Vol 41 (23) ◽

pp. 4521-4532 ◽

Cited By ~ 32

Author(s):

Joong-Youn Shim ◽

Elizabeth R. Collantes ◽

William J. Welsh ◽

Babu Subramaniam ◽

Allyn C. Howlett ◽

...

Keyword(s):

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Field Analysis ◽

Molecular Field ◽

Activity Relationship ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

Structure Activity ◽

Relationship Study

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A Comparative Molecular Field Analysis Model for 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines Binding Selectively to the Mitochondrial Benzodiazepine Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm00050a007 ◽

1994 ◽

Vol 37 (24) ◽

pp. 4100-4108 ◽

Cited By ~ 18

Author(s):

Giovanni Greco ◽

Ettore Novellino ◽

Isabella Fiorini ◽

Vito Nacci ◽

Giuseppe Campiani ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Analysis Model ◽

Molecular Field Analysis

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Three-Dimensional Quantitative Structure−Activity Relationship Study of the Inhibition of Na+,K+-ATPase by Cardiotonic Steroids Using Comparative Molecular Field Analysis†

Biochemistry ◽

10.1021/bi011511g ◽

2002 ◽

Vol 41 (4) ◽

pp. 1137-1148 ◽

Cited By ~ 23

Author(s):

Carol D. Farr ◽

Craig Burd ◽

Michael R. Tabet ◽

Xia Wang ◽

William J. Welsh ◽

...

Keyword(s):

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Field Analysis ◽

Molecular Field ◽

Activity Relationship ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

Structure Activity ◽

Relationship Study

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Three-dimensional quantitative structure activity relationship (QSAR) of cytotoxic active 3,5-diaryl-4,5-dihydropyrazole analogs: a comparative molecular field analysis (CoMFA) revisited study

Chemistry Central Journal ◽

10.1186/1752-153x-6-50 ◽

2012 ◽

Vol 6 (1) ◽

Cited By ~ 2

Author(s):

Abdel-Sattar S Hamad Elgazwy ◽

DaliaH S Soliman ◽

Saad R Atta-Allah ◽

Diaa A Ibrahim

Keyword(s):

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Field Analysis ◽

Molecular Field ◽

Activity Relationship ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

Molecular Field Analysis ◽

Structure Activity

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Structure–activity relationship study of human liver microsomes-catalyzed hydrolysis rate of ester prodrugs of MENT by comparative molecular field analysis (CoMFA)

Steroids ◽

10.1016/s0039-128x(02)00186-1 ◽

2003 ◽

Vol 68 (3) ◽

pp. 213-220 ◽

Cited By ~ 4

Author(s):

Roberta Bursi ◽

Arijan Grootenhuis ◽

Jaap van der Louw ◽

Jos Verhagen ◽

Marcel de Gooyer ◽

...

Keyword(s):

Human Liver ◽

Liver Microsomes ◽

Field Analysis ◽

Molecular Field ◽

Hydrolysis Rate ◽

Activity Relationship ◽

Comparative Molecular Field Analysis ◽

Structure Activity ◽

Relationship Study ◽

Ester Prodrugs

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Flavonoid Derivatives as Adenosine Receptor Antagonists: A Comparison of the Hypothetical Receptor Binding Site Based on a Comparative Molecular Field Analysis Model

Journal of Medicinal Chemistry ◽

10.1021/jm970446z ◽

1998 ◽

Vol 41 (1) ◽

pp. 46-52 ◽

Cited By ~ 35

Author(s):

Stefano Moro ◽

A. Michiel van Rhee ◽

Lawrence H. Sanders ◽

Kenneth A. Jacobson

Keyword(s):

Binding Site ◽

Receptor Binding ◽

Adenosine Receptor ◽

Field Analysis ◽

Molecular Field ◽

Comparative Molecular Field Analysis ◽

Analysis Model ◽

Receptor Antagonists ◽

Receptor Binding Site ◽

Molecular Field Analysis

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