scholarly journals Preparation and Characterization of Enteric Microspheres Containing Bovine Insulin by a w/o/w Emulsion Solvent Evaporation Method.

1998 ◽  
Vol 46 (10) ◽  
pp. 1613-1617 ◽  
Author(s):  
Norioko NAGAREYA ◽  
Takahiro UCHIDA ◽  
Kenji MATSUYAMA
Keyword(s):  
Bovine Insulin ◽  
Solvent Evaporation ◽  
Solvent Evaporation Method ◽  
Evaporation Method

scholarly journals Preparation and Characterization of Polylactic Acid Microspheres Containing Bovine Insulin by a w/o/w Emulsion Solvent Evaporation Method.

1997 ◽  
Vol 45 (9) ◽  
pp. 1539-1543 ◽  
Author(s):  
Takahiro UCHIDA ◽  
Noriko NAGAREYA ◽  
Sadako SAKAKIBARA ◽  
Yuriko KONISHI ◽  
Aki NAKAI ◽  
...  
Keyword(s):  
Polylactic Acid ◽  
Bovine Insulin ◽  
Solvent Evaporation ◽  
Solvent Evaporation Method ◽  
Evaporation Method

Glibenclamide-Nicotinamide Cocrystals Synthesized by The Solvent Evaporation Method to Enhance Solubility and Dissolution Rate of Glibenclamide

2019 ◽  
Vol 9 (01) ◽  
pp. 21-26
Author(s):  
Arif Budiman ◽  
Ayu Apriliani ◽  
Tazyinul Qoriah ◽  
Sandra Megantara
Keyword(s):  
Solvent Evaporation ◽  
Physical Mixture ◽  
Dissolution Profile ◽  
Solvent Evaporation Method ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Evaporation Method ◽  
Dissolution Properties ◽  
Mixture Characterization

Purpose: To develop glibenclamide-nicotinamide cocrystals with the solvent evaporation method and evaluate their solubility and dissolution properties. Methods: Cocrystals of glibenclamide-nicotinamide (1:2) were prepared with the solvent evaporation method. The prediction of interactive cocrystals was observed using in silico method. The solubility and dissolution were performed as evaluation of cocrystals. The cocrystals also were characterized by differential scanning calorimetry (DSC), infrared spectrophotometry, and powder X-ray diffraction (PXRD). Result: The solubility and dissolution profile of glibenclamide-nicotinamide cocrystal (1:2) increased significantly compared to pure glibenclamide as well as its physical mixture. Characterization of cocrystal glibenclamide-nicotinamide (1:2) including infrared Fourier transform, DSC, and PXRD, indicated the formation of a new solid crystal phase differing from glibenclamide and nicotinamide. Conclusion: The confirmation of cocrystal glibenclamide-nicotinamide (1:2) indicated the formation of new solid crystalline phases that differ from pure glibenclamide and its physical mixture

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