Novel Potassium Channel Activators: Synthesis and Structure-Activity Relationship Studies of 3,4-Dihydro-2H-1,4-benzoxazine Derivatives.

Yuzo MATSUMOTO; Ryuji TSUZUKI; Akira MATSUHISA; Kazuhisa TAKAYAMA; Toru YODEN; Wataru UCHIDA; Masaharu ASANO; Shigeo FUJITA; Isao YANAGISAWA; Takashi FUJIKURA

doi:10.1248/cpb.44.103

Novel Potassium Channel Activators: Synthesis and Structure-Activity Relationship Studies of 3,4-Dihydro-2H-1,4-benzoxazine Derivatives.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.44.103 ◽

1996 ◽

Vol 44 (1) ◽

pp. 103-114 ◽

Cited By ~ 31

Author(s):

Yuzo MATSUMOTO ◽

Ryuji TSUZUKI ◽

Akira MATSUHISA ◽

Kazuhisa TAKAYAMA ◽

Toru YODEN ◽

...

Keyword(s):

Potassium Channel ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Potassium Channel Activators

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ChemInform Abstract: Novel Potassium Channel Activators: Synthesis and Structure-Activity Relationship Studies of 3,4-Dihydro-2H-1,4-benzoxazine Derivatives.

ChemInform ◽

10.1002/chin.199630202 ◽

2010 ◽

Vol 27 (30) ◽

pp. no-no

Author(s):

Y. MATSUMOTO ◽

R. TSUZUKI ◽

A. MATSUHISA ◽

K. TAKAYAMA ◽

T. YODEN ◽

...

Keyword(s):

Potassium Channel ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Potassium Channel Activators

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2-Nicotinamidoethyl acetate (SG-209) is a potassium channel opener: Structure activity relationship among nicorandil derivatives

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/bf00167224 ◽

1991 ◽

Vol 344 (2) ◽

pp. 235-239 ◽

Cited By ~ 13

Author(s):

Takaharu Ishibashi ◽

Masami Hamaguchi ◽

Shoichi Imai

Keyword(s):

Potassium Channel ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Potassium Channel Opener ◽

Structure Activity ◽

Channel Opener

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Quantitative structure-activity relationship study of ATP-sensitive potassium channel openers: Derivatives of 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.1080/14756360701442381 ◽

2008 ◽

Vol 23 (1) ◽

pp. 1-6 ◽

Cited By ~ 5

Author(s):

B. K. Sharma ◽

S. K. Sharma ◽

P. Singh ◽

Susheela Sharma

Keyword(s):

Potassium Channel ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Potassium Channel Openers ◽

Structure Activity ◽

Relationship Study ◽

Derivatives Of

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Advances in Structure–Activity Relationship Studies on Potassium Channel Modulators

Ion Channels and Their Inhibitors ◽

10.1007/978-3-642-19922-6_8 ◽

2011 ◽

pp. 241-264

Author(s):

Brij K. Sharma ◽

Prithvi Singh ◽

Yenamandra S. Prabhakar

Keyword(s):

Potassium Channel ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Potassium Channel Modulators

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Development and Validation of a high-throughput Structure-Activity Relationship Assay for the hERG Potassium Channel

Biophysical Journal ◽

10.1016/j.bpj.2011.11.1808 ◽

2012 ◽

Vol 102 (3) ◽

pp. 330a

Author(s):

Daniel J. Gillie ◽

Steven J. Novick ◽

Brian T. Donovan ◽

Lisa A. Payne ◽

Claire Townsend

Keyword(s):

Potassium Channel ◽

High Throughput ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Development And Validation

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A Quantitative Structure-Activity Relationship Study on Some Series of Potassium Channel Blockers

Medicinal Chemistry ◽

10.2174/157340609787049244 ◽

2009 ◽

Vol 5 (1) ◽

pp. 87-92 ◽

Cited By ~ 4

Author(s):

V. Kumar Satuluri ◽

Jyostna Seelam ◽

S. Gupta

Keyword(s):

Potassium Channel ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Channel Blockers ◽

Quantitative Structure ◽

Structure Activity ◽

Potassium Channel Blockers ◽

Relationship Study

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Quantitative Structure-Activity Relationship Models for Predicting Biological Properties, Developed by Combining Structure- and Ligand-Based Approaches: An Application to the Human Ether-a-go-go-Related Gene Potassium Channel Inhibition

Chemical Biology & Drug Design ◽

10.1111/j.1747-0285.2009.00873.x ◽

2009 ◽

Vol 74 (4) ◽

pp. 416-433 ◽

Cited By ~ 5

Author(s):

Alessio Coi ◽

Ilaria Massarelli ◽

Marilena Saraceno ◽

Niccolò Carli ◽

Lara Testai ◽

...

Keyword(s):

Potassium Channel ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Biological Properties ◽

Activity Relationship ◽

Quantitative Structure ◽

Related Gene ◽

Structure Activity ◽

Channel Inhibition

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Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors: Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

Journal of Medicinal Chemistry ◽

10.1021/jm0204542 ◽

2003 ◽

Vol 46 (12) ◽

pp. 2413-2426 ◽

Cited By ~ 47

Author(s):

Richard W. Friesen ◽

Yves Ducharme ◽

Richard G. Ball ◽

Marc Blouin ◽

Louise Boulet ◽

...

Keyword(s):

Potassium Channel ◽

Binding Affinity ◽

Structure Activity Relationship ◽

Tertiary Alcohol ◽

Activity Relationship ◽

Related Gene ◽

Phosphodiesterase 4 ◽

Structure Activity

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4-Phenoxybutoxy-substituted heterocycles – A structure–activity relationship study of blockers of the lymphocyte potassium channel Kv1.3

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2008.10.033 ◽

2009 ◽

Vol 44 (5) ◽

pp. 1838-1852 ◽

Cited By ~ 38

Author(s):

Silke B. Bodendiek ◽

Cédrick Mahieux ◽

Wolfram Hänsel ◽

Heike Wulff

Keyword(s):

Potassium Channel ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study

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Discovery, Synthesis, and Structure–Activity Relationship of a Series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener

ACS Chemical Neuroscience ◽

10.1021/cn200065b ◽

2011 ◽

Vol 2 (10) ◽

pp. 572-577 ◽

Cited By ~ 35

Author(s):

Haibo Yu ◽

Meng Wu ◽

Steven D. Townsend ◽

Beiyan Zou ◽

Shunyou Long ◽

...

Keyword(s):

Potassium Channel ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Potassium Channel Opener ◽

Structure Activity ◽

Channel Opener ◽

Relationship Of

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