scholarly journals Influence of Formulation Change on Drug Release Kinetics from Hydroxypropylmethylcellulose Matrix Tablets.

1995 ◽  
Vol 43 (3) ◽  
pp. 483-487 ◽  
Author(s):  
Guojie XU ◽  
Hisakazu SUNADA
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Matrix Tablets ◽  
Drug Release Kinetics ◽  
Formulation Change

scholarly journals Predicting the drug release kinetics of matrix tablets

2009 ◽  
Vol 12 (2) ◽  
pp. 261-277 ◽  
Author(s):  
Boris Baeumer ◽  
◽  
Lipika Chatterjee ◽  
Peter Hinow ◽  
Thomas Rades ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Matrix Tablets ◽  
Drug Release Kinetics ◽  
Kinetics Of

Importance of drug type, tablet shape and added diluents on drug release kinetics from hydroxypropylmethylcellulose matrix tablets

1987 ◽  
Vol 40 (3) ◽  
pp. 223-234 ◽  
Author(s):  
James L. Ford ◽  
Michael H. Rubinstein ◽  
Fionan McCaul ◽  
John E. Hogan ◽  
Penny J. Edgar
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Matrix Tablets ◽  
Drug Release Kinetics ◽  
Drug Type

Modulation of drug release kinetics of shellac-based matrix tablets by in-situ polymerization through annealing process

2008 ◽  
Vol 69 (3) ◽  
pp. 1004-1013 ◽  
Author(s):  
S LIMMATVAPIRAT ◽  
C LIMMATVAPIRAT ◽  
S PUTTIPIPATKHACHORN ◽  
J NUNTHANID ◽  
M LUANGTANAANAN ◽  
...  
Keyword(s):  
Drug Release ◽  
In Situ Polymerization ◽  
Release Kinetics ◽  
Annealing Process ◽  
Matrix Tablets ◽  
Drug Release Kinetics ◽  
Kinetics Of

Modulation of drug release kinetics from hydroxypropyl methyl cellulose matrix tablets using polyvinyl pyrrolidone

2007 ◽  
Vol 337 (1-2) ◽  
pp. 246-253 ◽  
Author(s):  
Ian J. Hardy ◽  
Anne Windberg-Baarup ◽  
Claudia Neri ◽  
Paul V. Byway ◽  
Steven W. Booth ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Methyl Cellulose ◽  
Matrix Tablets ◽  
Polyvinyl Pyrrolidone ◽  
Hydroxypropyl Methyl Cellulose ◽  
Drug Release Kinetics ◽  
Cellulose Matrix

scholarly journals Drug Release Kinetics and Front Movement in Matrix Tablets Containing Diltiazem or Metoprolol/λ-Carrageenan Complexes

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Ruggero Bettini ◽  
Maria Cristina Bonferoni ◽  
Paolo Colombo ◽  
Laura Zanelotti ◽  
Carla Caramella
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Matrix Tablets ◽  
Drug Dissolution ◽  
Stable Complex ◽  
Drug Release Kinetics ◽  
The Matrix ◽  
Poorly Soluble ◽  
Drug Polymer Interaction ◽  
Polymer Interaction

In this work we investigated the moving boundaries and the associated drug release kinetics in matrix tablets prepared with two complexes betweenλ-carrageenan and two soluble model drugs, namely, diltiazem HCl and metoprolol tartrate aiming at clarifying the role played by drug/polymer interaction on the water uptake, swelling, drug dissolution, and drug release performance of the matrix. The two studied complexes released the drug with different mechanism indicating two different drug/polymer interaction strengths. The comparison between the drug release behaviour of the complexes and the relevant physical mixtures indicates that diltiazem gave rise to a less soluble and more stable complex with carrageenan than metoprolol. The less stable metoprolol complex afforded an erodible matrix, whereas the stronger interaction between diltiazem and carrageenan resulted in a poorly soluble, slowly dissolving matrix. It was concluded that the different stability of the studied complexes affords two distinct drug delivery systems: in the case of MTP, the dissociation of the complex, as a consequence of the interaction with water, affords a classical soluble matrix type delivery system; in the case of DTZ, the dissolving/diffusing species is the complex itself because of the very strong interaction between the drug and the polymer.

Sign in / Sign up

Export Citation Format

Share Document