scholarly journals A Convenient Synthesis of Tertiary Amines by Alkylation of Secondary Amines with Alkyl Halides in the Presence of Potassium Hydride and Triethylamine.

1995 ◽  
Vol 43 (1) ◽  
pp. 159-161 ◽  
Author(s):  
Kunihiko MOHRI ◽  
Kazumi SUZUKI ◽  
Masumi USUI ◽  
Kimiaki ISOBE ◽  
Yoshisuke TSUDA
Keyword(s):  
Alkyl Halides ◽  
Secondary Amines ◽  
Tertiary Amines ◽  
Convenient Synthesis ◽  
Potassium Hydride

Reaction of arylmethylenemalonaldehydes with some nucleophiles

1987 ◽  
Vol 52 (11) ◽  
pp. 2699-2709 ◽  
Author(s):  
Dalimil Dvořák ◽  
Zdeněk Arnold
Keyword(s):  
Inorganic Anions ◽  
Secondary Amines ◽  
Tertiary Amines ◽  
Primary And Secondary Amines ◽  
Dipolar Structure

Reaction of arylmethylenemalonaldehydes with tributylphosphine and tertiary amines affords compounds of dipolar structure whereas reaction with primary and secondary amines leads to 1,4-addition products. Salts of nucleophilic inorganic anions add to arylmethylenemalonaldehydes under formation of salts of substituted malonaldehydes.

Reaction of primary amines with Pt/C catalyst in water under microwave irradiation: a convenient synthesis of secondary amines from primary amines

2006 ◽  
Vol 47 (9) ◽  
pp. 1437-1439 ◽  
Author(s):  
Akira Miyazawa ◽  
Kaori Saitou ◽  
Kan Tanaka ◽  
Thomas M. Gädda ◽  
Masashi Tashiro ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Secondary Amines ◽  
Primary Amines ◽  
Convenient Synthesis

A Convenient Synthesis of Secondary Amines

Synthesis ◽  
1979 ◽  
Vol 1979 (01) ◽  
pp. 70-71 ◽  
Author(s):  
F. De Angelis ◽  
I. Grgurina ◽  
R. Nicoletti
Keyword(s):  
Secondary Amines ◽  
Convenient Synthesis

scholarly journals One-pot sequential synthesis of isocyanates and urea derivatives via a microwave-assisted Staudinger–aza-Wittig reaction

2013 ◽  
Vol 9 ◽  
pp. 2378-2386 ◽  
Author(s):  
Diego Carnaroglio ◽  
Katia Martina ◽  
Giovanni Palmisano ◽  
Andrea Penoni ◽  
Claudia Domini ◽  
...  
Keyword(s):  
Wittig Reaction ◽  
Scale Up ◽  
Alkyl Halides ◽  
Secondary Amines ◽  
Nucleophilic Substitutions ◽  
One Pot ◽  
Urea Derivatives ◽  
Step Process ◽  
Microwave Assisted ◽  
Simple Filtration

A fast and efficient protocol for the synthesis of N,N'-disubstituted urea derivatives from alkyl halides and primary or secondary amines has been developed. The synthetic pathway combines nucleophilic substitutions and a Staudinger–aza-Wittig reaction in the presence of polymer-bound diphenylphosphine under 14 bar of CO2 pressure and has been performed in a one-pot two-step process. The protocol has been optimized under microwave irradiation and the scale-up experiment has been conducted under conventional conditions in a Parr reactor. The final compounds were isolated after simple filtration in almost quantitative overall yields which makes this procedure facile and rapid to execute.

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