scholarly journals Pharmaceutical Characterization of Commercially Available Intravenous Fat Emulsions: Estimation of Average Particle Size, Size Distribution and Surface Potential Using Photon Correlation Spectroscopy.

1995 ◽  
Vol 43 (8) ◽  
pp. 1412-1415 ◽  
Author(s):  
Hiroaki KOMATSU ◽  
Aya KITAJIMA ◽  
Satoshi OKADA
Keyword(s):  
Particle Size ◽  
Size Distribution ◽  
Surface Potential ◽  
Photon Correlation Spectroscopy ◽  
Average Particle Size ◽  
Correlation Spectroscopy ◽  
Average Particle ◽  
Photon Correlation ◽  
Intravenous Fat Emulsions

scholarly journals Nanosized and Enhancement of Solubility Fisetin

2019 ◽  
Vol 7 (2) ◽  
pp. 6-10
Author(s):  
Muhammad Dzakwan ◽  
Eko Pramukantoro Ganet ◽  
Mauludin Rachmat ◽  
Saleh Wikarsa
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Photon Correlation Spectroscopy ◽  
Average Particle Size ◽  
Correlation Spectroscopy ◽  
Polydispersity Index ◽  
Average Particle ◽  
Polysorbate 80 ◽  
Photon Correlation ◽  
The Poor

Fisetin (3,3,4,7-tetrahydroxyflavone) is a natural antioxidant that has shown to posses anticancer, antioxidant and anti-inflammatory properties. However, the poor solubility leads to poor bioavailability and limits its development.The aim of the research is to investigate the effect of fisetin nanosuspension using a nanoprecipitation technique and additional stabilizers polysorbat 80, SLS, PVA and Eudragit on particle size average, polydispersity index and zeta potential.The suspensions of microcrystalline FIS were prepared by a nanoprecipitation technique with different proportion of stabilizers fixed. The nanosuspension produced was then characterized using Photon Correlation Spectroscopy (PCS) in  term of particle size distribution, polydispersity index, zeta potential and morphology nanosuspensiom (TEM). Result showed fisetin nanosuspension were successfully prepared by anti-solvent precipitation with additional stabilizer SLS and polysorbat 80. The nanosuspension containing polysorbat 80 showed smaller average particle size of 225.7 nm ± 1.31, a polydispersity index of 0.272 ±0.02 and zeta potential -39.3 ± 0.26 was obtained. Conclusion, FIS nanosuspension successfully prepared by nanoprecipitation tecnique with the polysorbate 80 as stabilizer and ethanol as solvent were spherical in shape..

Determination of Size Distribution of Fat Globules in Intravenous Fat Emulsions by Photon Correlation Spectroscopy

1989 ◽  
Vol 72 (3) ◽  
pp. 436-441
Author(s):  
Terry D Cyr ◽  
Robert C Lawrence ◽  
Edward G Lovering
Keyword(s):  
Size Distribution ◽  
Photon Correlation Spectroscopy ◽  
Correlation Spectroscopy ◽  
Photon Correlation ◽  
Fat Emulsions ◽  
Fat Globules ◽  
Large Particles ◽  
Fat Globule ◽  
Intravenous Fat Emulsions

Abstract A photon correlation spectroscopy method has been developed to characterize the size distribution of fat globules in intravenous fat emulsions (IFE) in terms of mean diameter, standard deviation of the distribution, and percentage of large particles outside the distribution. Mean fat globule diameters of samples of all IFE products available in Canada were about 0.3 μm, similar to values reported in the literature. The methodology is sufficiently sensitive to detect the presence of 5% by weight of 2 μm polystyrene microspheres in an intravenous fat emulsion. The effect of changes in instrument settings and variables on the results has been evaluated.

Preparation and Characterization of Gold Nanoparticles in the Presence of Citrate and Soybean Seed Extract in an Acidic Conditions

Drug Research ◽  
2017 ◽  
Vol 67 (05) ◽  
pp. 266-270 ◽  
Author(s):  
Ebrahim Izadi ◽  
Ali Rasooli ◽  
Abolfazl Akbarzadeh ◽  
Soodabeh Davaran
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Size Distribution ◽  
Average Particle Size ◽  
Soybean Seed ◽  
Average Particle ◽  
X Ray Diffraction ◽  
Soybean Extract ◽  
Average Size

AbstractThrough the present study, an eco-friendly method was used to synthesize the gold nanoparticles (GNPs) by using the sodium citrate and extract of the soybean seed as reducing the agents at PH 3. X-Ray diffraction (XRD) method was used to evaluate the crystal structure of as-synthesized NPs and it’s revealed that this method leads to well crystallized GNPs. In order to determine the particle size and their distribution, field emission scanning microscopy (FE-SEM) and dynamic light scattering (DLS) were used. The results showed that, the average particle size distribution of synthesized GNPs in solutions containing of the soybean extract and 1% citrate at PH 3 is about 109.6 and 140.9 nm, respectively. Also, we find that the average size of GNPs is 40 and 33 nm from solutions of citrate and soybean extract, respectively. It was concluded that using the extract of soybean seeds as reducing agent can lead to GNPs with small size and narrow size distribution.

Preparation and Characterization of Azithromycin-Loaded Nanostructured Lipid Carriers

2011 ◽  
Vol 236-238 ◽  
pp. 2917-2920 ◽  
Author(s):  
Jia Ying Wu ◽  
Qiang Xia
Keyword(s):  
Particle Size ◽  
Photon Correlation Spectroscopy ◽  
Correlation Spectroscopy ◽  
Nanostructured Lipid Carriers ◽  
High Pressure Homogenization ◽  
Photon Correlation ◽  
Mean Particle Size ◽  
Ophthalmic Preparation ◽  
The Mean

To function lipophilic drug Azithromycin (AZM) as ophthalmic preparation, Azithromycin-loaded Nanostructured Lipid Carriers (AZM-NLC) were prepared by High Pressure Homogenization (HPH), and its stability was analyzed afterwards. Well-dissolved lipids of Azithromycin were selected, how the ratio of surfactants to lipids influenced the preparation of AZM-NLC was studied, and mature surfactant system was chosen. The optimized ratio of lipid carriers to emulsifiers [ polyoxyethylene (40) stearate - Poloxamer188 (7:3)] in this study was 1:6, and the final drug-capacity rate was 0.5%. Obtained by photon correlation spectroscopy, the mean particle size of AZM-NLC was 76±2 nm. The results showed that AZM-NLC had kept stable for 15 days, and mean particle size increased to 83 nm after four months.

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