scholarly journals Macromolecule-Macromolecule Interaction in Drug Distribution. II. Effect of .ALPHA.-Globulin on Saturable Uptake of Fractionated (3H)Heparin by Rat Parenchymal Hepatocytes in Primary Culture.

1992 ◽  
Vol 40 (11) ◽  
pp. 3052-3055 ◽  
Author(s):  
Jun WATANABE ◽  
Hiroya MURANISHI ◽  
Hiroaki YUASA ◽  
Shoji OZEKI
Keyword(s):  
Primary Culture ◽  
Drug Distribution ◽  
Parenchymal Hepatocytes

scholarly journals Growth control of mature human parenchymal hepatocytes in primary culture: Relationships to collagen synthesis and non-parenchymal liver cells.

Kanzo ◽  
1989 ◽  
Vol 30 (10) ◽  
pp. 1481-1490
Author(s):  
Shigeharu TAKAI ◽  
Toshikazu NAKAMURA ◽  
Hiroo TAKEHARA ◽  
Nobuhiko KOMI ◽  
Akira ICHIHARA
Keyword(s):  
Primary Culture ◽  
Collagen Synthesis ◽  
Growth Control ◽  
Liver Cells ◽  
Parenchymal Liver ◽  
Parenchymal Hepatocytes

Cytopathology of Cardiac Tissue from Daunomycin-Treated Mice

1971 ◽  
Vol 29 ◽  
pp. 550-551
Author(s):  
Robert H. Liss ◽  
Frances A. Cotton
Keyword(s):  
Cardiac Tissue ◽  
Cardiac Toxicity ◽  
Drug Distribution ◽  
Personal Communication ◽  
Intravenous Dose ◽  
Single Intravenous Dose ◽  
Physiologic Saline ◽  
Histopathologic Changes ◽  
Distribution Studies ◽  
Lung And Kidney

Daunomycin, an antibiotic used in the clinical management of acute leukemia, produces a delayed, lethal cardiac toxicity. The lethality is dose and schedule dependent; histopathologic changes induced by the drug have been described in heart, lung, and kidney from hamsters in both single and multiple dose studies. Mice given a single intravenous dose of daunomycin (10 mg/kg) die 6-7 days later. Drug distribution studies indicate that the rodents excrete most of a single dose of the drug as daunomycin and metabolite within 48 hours after dosage (M. A. Asbell, personal communication).Myocardium from the ventricles of 6 moribund BDF1 mice which had received a single intravenous dose of daunomycin (10 mg/kg), and from controls dosed with physiologic saline, was fixed in glutaraldehyde and prepared for electron microscopy.

Primary culture of rat ependymal cells in serum-free defined medium

1986 ◽  
Vol 390 (2) ◽  
pp. 199-209 ◽  
Author(s):  
M WEIBEL ◽  
B PETTMANN ◽  
J ARTAULT ◽  
M SENSENBRENNER ◽  
G LABOURDETTE
Keyword(s):  
Primary Culture ◽  
Defined Medium ◽  
Ependymal Cells ◽  
Serum Free

Partial Characterization of a Fibrinolytic Inhibitor Produced by Cultured Endothelial Cells Derived from Human Umbilical Vein

1982 ◽  
Vol 47 (02) ◽  
pp. 128-131 ◽  
Author(s):  
F Esnard ◽  
E Dupuy ◽  
A M Dosne ◽  
E Bodevin
Keyword(s):  
Endothelial Cells ◽  
Primary Culture ◽  
Ammonium Sulphate ◽  
Concanavalin A ◽  
Umbilical Vein ◽  
Human Umbilical Vein ◽  
Preliminary Characterization ◽  
Umbilical Vein Endothelial Cells ◽  
Ammonium Sulphate Saturation

SummaryA preliminary characterization of a fibrinolytic inhibitor released by human umbilical vein endothelial cells in primary culture is reported. This molecule of Mr comprised between 2 × 105 and 106 and of μ2 mobility precipitates at 43% ammonium sulphate saturation and is totally adsorbed on Concanavalin A Sepharose 4 B. A possible relationship with a macroglobulins is discussed.

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