scholarly journals Pharmacological studies on EB-382, a new non-steroidal antiinflammatory agents: Mode of action of the analgesic effects.

1989 ◽  
Vol 37 (3) ◽  
pp. 775-777 ◽  
Author(s):  
Toshio FUJIYOSHI ◽  
Hiroyuki IIDA ◽  
Motoya MURAKAMI ◽  
Miho KUWASHIMA ◽  
Toshio UEMATSU
Keyword(s):  
Mode Of Action ◽  
Analgesic Effects ◽  
Antiinflammatory Agents ◽  
Pharmacological Studies

scholarly journals Alkaloid Profiles and Activity in Different Mitragyna speciosa Strains

2018 ◽  
Vol 13 (9) ◽  
pp. 1934578X1801300 ◽  
Author(s):  
Luisa Boffa ◽  
Corrado Ghè ◽  
Alessandro Barge ◽  
Giampiero Muccioli ◽  
Giancarlo Cravotto
Keyword(s):  
Geographic Origin ◽  
Plant Leaves ◽  
Analgesic Effects ◽  
Total Alkaloids ◽  
Mitragyna Speciosa ◽  
Organic Extraction ◽  
Pharmacological Studies ◽  
Different Strains ◽  
Pharmacologically Active

Mitragyna speciosa (K.) H. (Kratom) is a tree that possesses stimulant and opioid-like analgesic effects, and is indigenous to Southeast Asia and Indochina, where it has seen widespread use for hundreds of years. The principal pharmacologically active alkaloids in kratom leaves include mitragynine (MG), 7-hydroxymitragynine (HMG), speciociliatine (SC), speciogynine (SG) and paynantheine (P). The pharmacological effects induced and their potency can vary dramatically according to variations in the proportions of alkaloid compounds present, which are related to geographic origin, stage of maturity and ecotype. Much of the analgesic and opiate-like psychoactive effect of kratom has been associated with the MG and HMG detected in M. speciosa (K.). H. Five different strains of M. speciosa (K.) H., which present differing vein colours and geographic origin, have been studied herein; red vein strains from Thailand, Malaysia and Bali, named Red Thai, Red Malay and Red Bali, a white vein strain from Borneo (White Borneo) and a green vein strain from Malaysia (Green Malay) were included in the study. Plant leaves were extracted under magnetic stirring at room temperature in a MeOH/H2O 1:1 mixture. Purified alkaloids were isolated in a number of organic extraction steps, from either aqueous basic or acidic phases, that culminated in precipitation (yields between 0.94 and 1.43%). These samples have been analysed using HPLC-DAD, HPLC-MS, HPLC-MS/MS and GC-MS to optimize the identification and quantification of the principal alkaloids present in the different strains. 24 alkaloids were detected in Red Bali whereas 11 compounds were found in the other varieties. Red Thai, Red Bali, Green Malay and White Borneo strains had a higher w/w percentage for MG than for P, while P was more abundant in Red Malay. The Green Malay variety (GMK) showed the highest w/w percentages for MG and total alkaloids in its extracts (59.7 and 94.9% respectively). The Green Malay variety was therefore chosen for in vivo pharmacological studies. The Green Malay extract has shown remarkable and significant antinociceptive and anti-inflammatory activity in mouse hot plate and carrageenan-induced paw edema tests.

scholarly journals Comparison of Analgesic Effects of Novafen and Ibuprofen after Periodontal Surgeries

2017 ◽  
Vol 5 (1) ◽  
pp. 1
Author(s):  
Amirreza Babaloo ◽  
Mahdi Rahbar ◽  
Shima Ghasemi ◽  
Mohammadtaghi Chitsazi ◽  
Hamed Moradzadeh
Keyword(s):  
Healthy Subjects ◽  
Analgesic Efficacy ◽  
Analgesic Effects ◽  
Antiinflammatory Agents ◽  
Dental Procedures ◽  
Relieve Pain ◽  
Minute Interval ◽  
Group 2 ◽  
Ibuprofen Group ◽  
Group 1

Introduction: Management of pain after dental procedures is one of the most important issues for dentists. Non-steroidal antiinflammatory agents, such as ibuprofen, are one of the most commonly used medications to relieve pain. Recently a new medication, Novafen, has been introduced into the Iranian pharmaceutical market, which is a combination of ibuprofen, acetaminophen and caffeine. Considering the importance of management of pain after periodontal surgeries and a paucity of studies in this respect, the present study was undertaken to compare the analgesic efficacy of Novafen and ibuprofen in alleviating pain after periodontal surgeries. Materials and methods: In the present controlled randomized clinical trial, 30 systemically healthy subjects with moderate to severe generalized chronic periodontitis, who were candidates for flap surgeries were evaluated in two groups with 30 areas in each group (two areas in each patient). After the periodontal surgical procedures, the subjects in group 1 received Novafen capsules (containing 325 mg of acetaminophen, 200 mg of ibuprofen and 40 mg of caffeine) and the subjects in group 2 received ibuprofen (400 mg). The medications were selected from one pharmaceutical company and the patients only used the medications they received. The severity of pain was determined and compared at 3-minute, 1-hour and 3-hour intervals using VAS and 1, 2 and 3 days postoperatively using VRS. Results: Severity of pain at 30-minute interval in the Novafen group was significantly less than that in the ibuprofen group, with no significant differences at 1- and 3-hour intervals. However, VRS revealed significantly less pain 1, 2 and 3 days postoperatively in the Novafen group compared to the ibuprofen group. Conclusion: Based on the results of the present study, it can be concluded than Novafen can be more effective after periodontal surgeries in alleviating pain. However, its pain control capacity was similar to that of ibuprofen during the early postoperative hours, with better performance 1‒3  days postoperatively.Key words: Novafen; ibuprofen; pain relief; periodontal surgery; Analgesia;

scholarly journals Chemical constituents and biological activities of Artocarpus heterophyllus lam (Jackfruit): A review

2021 ◽  
Vol 4 (1) ◽  
pp. 005-009
Author(s):  
Bhad Pranay Raja ◽  
Bobde Meeneri Vilas ◽  
G Sibi
Keyword(s):  
Bioactive Compounds ◽  
Mode Of Action ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Deciduous Tree ◽  
Anticancer Activities ◽  
Artocarpus Heterophyllus ◽  
Edible Fruit ◽  
Pharmacological Studies ◽  
Promising Source

Artocarpus (Moraceae) is a deciduous tree with appreciable importance as a source of edible fruit and is widely used in folk medicines. The extracts and metabolites of Artocarpus heterophyllus particularly those from leaves, bark, stem and fruit possess several useful bioactive compounds. This review indents to compile various studies on A. heterophyllus and critically evaluates its ethnomedical and ethnopharmacological properties. Several pharmacological studies from A. heterophyllus have conclusively established their mode of action in anti-inflammatory, antimicrobial, antioxidant and anticancer activities. Based on the available data, it is concluded that Artocarpus as a promising source of useful products and opens up new avenues for novel therapeutics.

scholarly journals Pharmacological studies on EB-382, a new non-steroidal antiinflammatory agent: Mode of action of the antiinflammatory effects.

1989 ◽  
Vol 37 (3) ◽  
pp. 771-774 ◽  
Author(s):  
Toshio FUJIYOSHI ◽  
Hiroyuki IIDA ◽  
Motoya MURAKAMI ◽  
Miho KUWASHIMA ◽  
Toshio UEMATSU
Keyword(s):  
Mode Of Action ◽  
Antiinflammatory Agent ◽  
Pharmacological Studies ◽  
Agent Mode ◽  
Antiinflammatory Effects
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