scholarly journals Studies on proton pump inhibitors. II. Synthesis and antiulcer activity of 8-((2-benzimidazolyl)-sulfinylmethyl)-1,2,3,4-tetrahydroquinolines and related compounds.

1989 ◽  
Vol 37 (8) ◽  
pp. 2109-2116 ◽  
Author(s):  
Minoru UCHIDA ◽  
Masatoshi CHIHIRO ◽  
Seiji MORITA ◽  
Toshimi KANBE ◽  
Hiroshi YAMASHITA ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Antiulcer Activity ◽  
Related Compounds

scholarly journals Studies on proton pump inhibitors. III. Synthesis of 8-((2-benzimidazolyl)sulfinylmethyl)-1,2-di-hydroquinolines and related compounds.

1990 ◽  
Vol 38 (2) ◽  
pp. 534-537 ◽  
Author(s):  
Minoru UCHIDA ◽  
Masatoshi CHIHIRO ◽  
Seiji MORITA ◽  
Hiroshi YAMASHITA ◽  
Katsuya YAMASAKI ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Related Compounds

scholarly journals Design and Synthesis of Novel Imidazopyridine Analogues and Evaluation as H+/K+-ATPase Antagonist

2020 ◽  
Vol 32 (11) ◽  
pp. 2685-2692
Author(s):  
R.S. Sonawane ◽  
Mrunal Shirsat ◽  
S.R. Patil ◽  
J.C. Hundiwale ◽  
A.V. P atil
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Inhibitory Activity ◽  
Docking Study ◽  
Positive Control ◽  
Antiulcer Activity ◽  
Molecular Docking Study ◽  
Design And Synthesis ◽  
Imidazopyridine Derivatives

CID data base were explored considering AZD0865 as standard and docked in proton pump ATPase pocket (PDB ID: 4ux2) to find out novel imidazopyridine derivatives as proton pump inhibitors. A number of compounds showed good proton pump ATPase inhibitory activity as per the molecular docking study as compared to standard compound AZD0865. The compound AZD0865showed a docking score of -7.11 and revealed the interactions with amino acids Asn 138 and Asp 137. A series of novel imidazopyridine derivatives as proton pump inhibitors were docked, synthesized and characterized by IR, NMR, CHN and MS spectral analysis. The target imidazopyridines were prepared from the intermediate substituted 2-aminonicotinic acid and 2-bromo-1-substituted ethanone. in vitro pharmacological studies explained that some compounds exhibited moderate to good proton pump ATPase inhibitory activity in comparison with the reference drugs i.e. AZD0865. Compound N-(3-(aminomethyl)benzyl)-3-(benzylamino)-2-(o-tolyl)imidazo[1,2-a]pyridine-8-carboxamide and N-(3-(aminomethyl)benzyl)-3-(benzylamino)-2-(4-ethylphenyl)imidazo[1,2-a]pyridine-8-carboxamide showed higher activities with the IC50 6.2 and 6.0 μg. Many compounds showed IC50 as weak antiulcer activity as compared to positive control AZD0865.

scholarly journals Studies on proton pump inhibitors. I. Synthesis of 8-((2-benzimidazolyl)sulfinyl)-5,6,7,8-tetrahydroquinolines and related compounds.

1989 ◽  
Vol 37 (6) ◽  
pp. 1517-1523 ◽  
Author(s):  
Minoru UCHIDA ◽  
Seiji MORITA ◽  
Masatoshi CHIHIRO ◽  
Toshimi KANBE ◽  
Katsuya YAMASAKI ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Related Compounds

Inhibitory effect of proton pump inhibitors against chemotaxis of Helicobacter pylori

2001 ◽  
Vol 120 (5) ◽  
pp. A655-A656
Author(s):  
H NAKAMURA ◽  
H YOSHIYAMA ◽  
H YANAI ◽  
M SHIRAL ◽  
T NAKAZAWA ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Inhibitory Effect

Abstract #728: Severe Hypomagnesemia and Breakthrough Seizure with Proton Pump Inhibitors Use

2015 ◽  
Vol 21 ◽  
pp. 139
Author(s):  
Muhammad Mahmood ◽  
Andrew Kinch ◽  
Woodall Brittany ◽  
Ayman Elkadry
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Breakthrough Seizure

Abstract #713 Proton Pump Inhibitors and Hypocalcemia: Does it Really Happen?

2018 ◽  
Vol 24 ◽  
pp. 157-158
Author(s):  
Franco Vallejo Garcia ◽  
Melissa Sum
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump

Erratum: Overutilization of Proton Pump Inhibitors: A Review of Cost-Effectiveness and Risk in PPI

2009 ◽  
Vol 104 (4) ◽  
pp. 1072-1072
Author(s):  
Joel J Heidelbaugh ◽  
Kathleen L Goldberg ◽  
John M Inadomi
Keyword(s):  
Cost Effectiveness ◽  
Proton Pump Inhibitors ◽  
Proton Pump
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