scholarly journals Pharmacological studies of furo(3,2-b)indole derivatives. III. Correlation between analgesic effect and effect on central nervous system of N-(3-piperidinopropyl)-4-methyl-6-trifluoromethyl furo(3,2-b)indole-2-carboxamide (FI-302) in mice.

1987 ◽  
Vol 35 (7) ◽  
pp. 2973-2978
Author(s):  
FUSAO AMANUMA ◽  
TSUTOMU KAMEYAMA
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Analgesic Effect ◽  
Indole Derivatives ◽  
Pharmacological Studies

Neuropharmacological Profile and Chemical Analysis of Moroccan Ormenis mixta L.

2018 ◽  
Vol 16 (S1) ◽  
pp. S55-S64
Author(s):  
G. Hajjaj ◽  
A. Bahlouli ◽  
M. Tajani ◽  
K. Alaoui ◽  
Y. Cherrah ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Body Weight ◽  
Traditional Medicine ◽  
Behavioral Tests ◽  
Phytochemical Screening ◽  
Activity Profile ◽  
Acute Toxicity Study ◽  
Pharmacological Studies

Ormenis mixta L. is traditionally used for central nervous system (CNS)-related diseases. Its anti-stress properties have received attention in Moroccan traditional medicine and aromatherapy. However, no pharmacological studies have yet been undertaken on this plant in Morocco. The present study provides a preliminary phytochemical screening and psychopharmacological profile of the essential oil and aqueous extract from Ormenis mixta L. by using behavioral tests in vivo, at graded doses. The result of this research shows that Ormenis mixta L. was safe up to 2 g/kg b.w. (body weight) in the acute toxicity study, possesses potential psychostimulant effect, and has antianxiety and antidepressant-like activity. This activity profile of Ormenis mixta L. was similar to the typical psychostimulant, caffeine. The exact mechanism of action underlying this stimulant-like effect should be clarified with further detailed studies. These results explained the extensive use of Ormenis mixta L. as a traditional medicine in Morocco.

Central Nervous System Activities of Indole Derivatives: An Overview

2015 ◽  
Vol 16 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Teena Saini ◽  
Sanjiv Kumar ◽  
Balasubramanian Narasimhan
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Indole Derivatives

scholarly journals Bacopa monnieri: Historical aspects to promising pharmacological actions for the treatment of central nervous system diseases

2022 ◽  
Vol 21 (2) ◽  
pp. 131-155
Author(s):  
Andreia Fuentes Santos ◽  
◽  
Marilia Moraes Queiroz Souza ◽  
Karoline Bach Pauli ◽  
Gustavo Ratti da Silva ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cognitive Processes ◽  
Biological Effects ◽  
Bacopa Monnieri ◽  
Cellular Mechanisms ◽  
Healthy Elderly ◽  
Pharmacological Studies ◽  
Gastrointestinal Side Effects ◽  
The Central Nervous System

Bacopa monnieri(L.) Wettst. (Plantaginaceae), also known as Brahmi, has been used to improve cognitive processes and intellectual functions that are related to the preservation of memory. The objective of this research is to review the ethnobotanical applications, phytochemical composition, toxicity and activity of B. monnieriin the central nervous system. It reviewed articles on B. monnieriusing Google Scholar, SciELO, Science Direct, Lilacs, Medline, and PubMed. Saponins are the main compounds in extracts of B. monnieri. Pharmacological studies showed that B. monnieriimproves learning and memory and presents biological effects against Alzheimer’s disease, Parkinson’s disease, epilepsy, and schizophrenia. No preclinical acute toxicity was reported. However, gastrointestinal side effects were reported in some healthy elderly individuals. Most studies with B. monnierihave been preclinical evaluations of cellular mechanisms in the central nervous system and further translational clinical research needs to be performed to evaluate the safety and efficacy of the plant.

scholarly journals Influence of bile acid derivates on morphine analgesic effect in mice

2014 ◽  
Vol 71 (8) ◽  
pp. 767-771 ◽  
Author(s):  
Velibor Vasovic ◽  
Sasa Vukmirovic ◽  
Momir Mikov ◽  
Ivan Mikov ◽  
Zorana Budakov ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Methyl Ester ◽  
Bile Acids ◽  
Analgesic Effect ◽  
White Male ◽  
Subcutaneous Administration ◽  
Morphine Administration ◽  
The Central Nervous System

Background/Aim. It is known that bile acids improve the absorption, bioavailability and pharmacodynamic characteristics of some drugs. Morphine analgesia is produced by activation of opioid receptors within the central nervous system (CNS) at both spinal and supraspinal levels. Since a morphine molecule contains 3 polar groups and therefore hard to transfer through the blood-brain barrier, the aim of the study was to examine the potential influence of bile acids derivates, namely sodium salt of monoketocholic acid (MKH-Na) and methyl ester of monoketocholic acid (MKH-Me), on analgesic effect of morphine. Methods. White male mice of NMRI-Haan strain, with body weight of 20-24 g, were used in this study. The analgesic effect of morphine (administered by subcutaneous and intramuscular route in a dose of 2 mg/kg), with and without pretreatment with MKH-Na (4 mg/kg) and MKH-Me (4 mg/kg) was estimated by the hot plate method. Results. Administration of MKH-Me prior to subcutaneous administration of morphine increased the morphine analgesic effect but the increase was not statistically significant. At the same time administration of MKH-Na did not affect morphine analgesic effect. The analgesic effect of morphine increased when administered intramuscularly 20 min after MKH-Me administration. When compared with the group of animals treated only with morphine, a statistically significant increase in analgesic effect was detected 10, 30, 40 and 50 min after morphine administration (p < 0.05). Pretreatment with MKH-Na did not affect morphine analgesic effect. Conclusion. According to the results of this study it can be presumed that after intramuscular morphine administration methyl ester of monoketocholic acid increases morphine transport into the central nervous system and consequently the analgesic effect, as well. Further research on bile acids-morphine interaction both in vitro and in vivo is necessary to completely elucidate the mechanism of this interaction and increase in the morphine analgesic effect.

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