scholarly journals Intestinal absorption of a .BETA.-adrenergic blocking agent nadolol. II Mechanism of the inhibitory effect on the intestinal absorption of nadolol by sodium cholate in rats.

1986 ◽  
Vol 34 (9) ◽  
pp. 3836-3843 ◽  
Author(s):  
TOSHIKAZU YAMAGUCHI ◽  
CHISATO IKEDA ◽  
YUTAKA SEKINE
Keyword(s):  
Intestinal Absorption ◽  
Blocking Agent ◽  
Sodium Cholate ◽  
Inhibitory Effect ◽  
Beta Adrenergic ◽  
Adrenergic Blocking

ADRENERGIC CONTROL MECHANISM FOR ACTH SECRETION IN MAN

1973 ◽  
Vol 74 (2) ◽  
pp. 263-270 ◽  
Author(s):  
Yoshikatsu Nakai ◽  
Hiroo Imura ◽  
Teruya Yoshimi ◽  
Shigeru Matsukura
Keyword(s):  
Intravenous Infusion ◽  
Human Subjects ◽  
Blocking Agent ◽  
Inhibitory Effect ◽  
Plasma Acth ◽  
Acth Secretion ◽  
Glucose Levels ◽  
Alpha Receptors ◽  
Normal Human ◽  
Adrenergic Blocking

ABSTRACT In order to determine if an adrenergic mechanism is involved in the secretion of corticotrophin (ACTH), the effect of adrenergic-blocking or -stimulating agent on plasma ACTH, cortisol and glucose levels was studied in normal human subjects. The intravenous infusion of methoxamine, an alpha adrenergic-stimulating agent, caused a rise in plasma ACTH and cortisol. This increase in plasma ACTH and cortisol was significantly inhibited by the simultaneous administration of phentolamine, an alpha adrenergic-blocking agent, in combination with methoxamine. The intravenous infusion of propranolol, a beta adrenergic-blocking agent, caused no significant change in plasma ACTH and cortisol, although it enhanced the plasma ACTH response to insulin-induced hypoglycaemia. On the other hand, alpha adrenergicblockade by intravenous infusion of phentolamine significantly suppressed the plasma ACTH response to insulin-induced hypoglycaemia. These studies suggest a stimulatory effect of alpha receptors and a possible inhibitory effect of beta receptors on ACTH secretion in man.

Evaluation of a new beta-adrenergic blocking agent, carteolol, based on metabolic responses in rats—I

1976 ◽  
Vol 25 (16) ◽  
pp. 1837-1842 ◽  
Author(s):  
Seiji Morita ◽  
Yasuo Irie ◽  
Yuichi Saitoh ◽  
Hideaki Kohri
Keyword(s):  
Blocking Agent ◽  
Metabolic Responses ◽  
Beta Adrenergic ◽  
Adrenergic Blocking

scholarly journals 14C-labelling of a new .BETA.-adrenergic blocking agent (S-596)

RADIOISOTOPES ◽  
1982 ◽  
Vol 31 (2) ◽  
pp. 101-103 ◽  
Author(s):  
Akira YOSHITAKE ◽  
Hideyuki GOMI ◽  
Iwao NAKATSUKA
Keyword(s):  
Blocking Agent ◽  
Beta Adrenergic ◽  
14C Labelling ◽  
Adrenergic Blocking
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