scholarly journals Triterpenoid glycosides from the roots of Tetrapanax papyriferum K. Koch. III. Structures of four new saponins.

1985 ◽  
Vol 33 (11) ◽  
pp. 4701-4706 ◽  
Author(s):  
SEIICHI TAKABE ◽  
TADAHIRO TAKEDA ◽  
YINGJIE CHEN ◽  
YUKIO OGIHARA
Keyword(s):  
Tetrapanax Papyriferum ◽  
Triterpenoid Glycosides

Two new triterpenoid glycosides from leaves of Cyclocarya paliurus

2021 ◽  
pp. 1-6
Author(s):  
Huihui Sun ◽  
Hui Zhu ◽  
Jianping Wu ◽  
Yuyan Wang ◽  
Guihua Li ◽  
...  
Keyword(s):  
Cyclocarya Paliurus ◽  
Triterpenoid Glycosides

scholarly journals One-Pot Bi-Enzymatic Cascade Synthesis of Novel Ganoderma Triterpenoid Saponins

Catalysts ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 580
Author(s):  
Te-Sheng Chang ◽  
Chien-Min Chiang ◽  
Tzi-Yuan Wang ◽  
Yu-Li Tsai ◽  
Yu-Wei Wu ◽  
...  
Keyword(s):  
High Performance ◽  
Aqueous Solubility ◽  
Major Product ◽  
Cyclodextrin Glucanotransferase ◽  
Bioactive Constituents ◽  
Ganoderic Acid ◽  
One Pot ◽  
Triterpenoid Saponins ◽  
Medicinal Fungus ◽  
Triterpenoid Glycosides

Ganoderma lucidum is a medicinal fungus whose numerous triterpenoids are its main bioactive constituents. Although hundreds of Ganoderma triterpenoids have been identified, Ganoderma triterpenoid glycosides, also named triterpenoid saponins, have been rarely found. Ganoderic acid A (GAA), a major Ganoderma triterpenoid, was synthetically cascaded to form GAA-15-O-β-glucopyranoside (GAA-15-G) by glycosyltransferase (BtGT_16345) from Bacillus thuringiensis GA A07 and subsequently biotransformed into a series of GAA glucosides by cyclodextrin glucanotransferase (Toruzyme® 3.0 L) from Thermoanaerobacter sp. The optimal reaction conditions for the second-step biotransformation of GAA-15-G were found to be 20% of maltose; pH 5; 60 °C. A series of GAA glucosides (GAA-G2, GAA-G3, and GAA-G4) could be purified with preparative high-performance liquid chromatography (HPLC) and identified by mass and nucleic magnetic resonance (NMR) spectral analysis. The major product, GAA-15-O-[α-glucopyranosyl-(1→4)-β-glucopyranoside] (GAA-G2), showed over 4554-fold higher aqueous solubility than GAA. The present study demonstrated that multiple Ganoderma triterpenoid saponins could be produced by sequential actions of BtGT_16345 and Toruzyme®, and the synthetic strategy that we proposed might be applied to many other Ganoderma triterpenoids to produce numerous novel Ganoderma triterpenoid saponins in the future.

Holothurinosides: New antitumour non sulphated triterpenoid glycosides from the sea cucumber holothuria forskalii.

Tetrahedron ◽  
1991 ◽  
Vol 47 (26) ◽  
pp. 4753-4762 ◽  
Author(s):  
Jaime Rodriguez ◽  
Rita Castro ◽  
Ricardo Riguera
Keyword(s):  
Sea Cucumber ◽  
Triterpenoid Glycosides

Detection of Triterpenoid Glycosides on Paper Chromatograms

Nature ◽  
1956 ◽  
Vol 178 (4532) ◽  
pp. 538-538 ◽  
Author(s):  
I. BELIČ
Keyword(s):  
Triterpenoid Glycosides

scholarly journals An RP-LC-UV-TWIMS-HRMS and Chemometric Approach to Differentiate between Momordicabalsamina Chemotypes from Three Different Geographical Locations in Limpopo Province of South Africa

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1896
Author(s):  
Pieter Venter ◽  
Kholofelo Malemela ◽  
Vusi Mbazima ◽  
Leseilane J. Mampuru ◽  
Christo J. F. Muller ◽  
...  
Keyword(s):  
Molecular Species ◽  
High Resolution Mass Spectrometry ◽  
Parent Compound ◽  
Travelling Wave ◽  
Reversed Phase ◽  
Limpopo Province ◽  
Leaf Extracts ◽  
Triterpenoid Glycosides ◽  
Ht 29 ◽  
Geographical Locations

Momordica balsamina leaf extracts originating from three different geographical locations were analyzed using reversed-phase liquid chromatography (RP-LC) coupled to travelling wave ion mobility (TWIMS) and high-resolution mass spectrometry (HRMS) in conjunction with chemometric analysis to differentiate between potential chemotypes. Furthermore, the cytotoxicity of the three individual chemotypes was evaluated using HT-29 colon cancer cells. A total of 11 molecular species including three flavonol glycosides, five cucurbitane-type triterpenoid aglycones and three glycosidic cucurbitane-type triterpenoids were identified. The cucurbitane-type triterpenoid aglycones were detected in the positive ionization mode following dehydration [M + H − H2O]+ of the parent compound, whereas the cucurbitane-type triterpenoid glycosides were primarily identified following adduct formation with ammonia [M + NH4]+. The principle component analysis (PCA) loadings plot and a variable influence on projection (VIP) analysis revealed that the isomeric pair balsaminol E and/or karavilagen E was the key molecular species contributing to the distinction between geographical samples. Ultimately, based on statistical analysis, it is hypothesized that balsaminol E and/or karavilagen E are likely responsible for the cytotoxic effects in HT-29 cells.

Extraction, isolation and structural characterization of two triterpenoid glycosides from the fruits of Ficus bengalensis

2021 ◽  
pp. 108444
Author(s):  
Mohammad Sohail Akhtar ◽  
S.R. Mir ◽  
Sadri Abdullah Said ◽  
Mohammad Amzad Hossain ◽  
Mohammad Ali
Keyword(s):  
Structural Characterization ◽  
Triterpenoid Glycosides ◽  
Ficus Bengalensis

scholarly journals Multiple Oral Dosing Pharmacokinetics of Standardized Extract of Centella asiatica ECa 233 and Its Inductive Effect on Efflux Transporters in Rats

2017 ◽  
Vol 4 (02) ◽  
pp. e66-e73 ◽  
Author(s):  
Tosapol Anukunwithaya ◽  
Mayuree Tantisira ◽  
Tsutomu Shimada ◽  
Yoshimichi Sai ◽  
Phisit Khemawoot
Keyword(s):  
Inductive Effect ◽  
Area Under The Curve ◽  
Centella Asiatica ◽  
Pharmacokinetic Data ◽  
Maximum Plasma ◽  
Asiatic Acid ◽  
Multiple Dosing ◽  
Oral Dosing ◽  
Blood Biochemical ◽  
Triterpenoid Glycosides

AbstractECa 233 is a standardized extract of Centella asiatica, characterized as a white powder containing triterpenoid glycosides not less than 80% with a ratio of madecassoside to asiaticoside of 1.5±0.5:1. Although pharmacological and toxicological profiles of ECa 233 have been successively reported, the pharmacokinetic data needed for further therapeutic development are not fully elucidated. This study aimed to investigate the pharmacokinetics of multiple oral dosing of ECa 233 at 100 mg/kg/day for 7 days in rats. Plasma, tissues, urine, and feces were collected from 0 to 24 h after dosing on days 1 and 7. The concentrations of asiaticoside, madecassoside, asiatic acid, and madecassic acid were simultaneously analyzed by liquid chromatography-tandem mass spectrometry. No significant change was observed in physical and blood biochemical parameters of the animals treated with ECa 233 for 7 days. The maximum plasma concentration and area under the curve at day 7 of madecassoside and asiaticoside decreased by 70–80% from day 1. However, both triterpenoid glycosides were extensively distributed and accumulated, resulting in significantly higher concentrations at pharmacologically relevant organs. Madecasssic acid and asiatic acid are major metabolites mainly found in and excreted via feces. Moreover, multiple dosing of ECa 233 increased mRNA expression of Abcb1a and Abcc2 in the small intestine by approximately 2- to 3-fold. This is the first study to identify an inductive effect of a standardized extract of C. asiatica after multiple oral dosing in rats. Potential drug-herb interactions when ECa 233 is coadministered with Abcb1a and Abcc2 substrates calls for further investigations.

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