scholarly journals Spirocyclopropane compounds. IV. Synthesis of 5-acetylspiro(benzofuran-2(3H),1'-cyclopropan)-3-one related compounds for evaluation as gastric antisecretory and antiulcer agents.

1984 ◽  
Vol 32 (9) ◽  
pp. 3551-3560 ◽  
Author(s):  
MASAZUMI WATANABE ◽  
MITSURU KAWADA ◽  
TAKEO HIRATA ◽  
YOSHITAKA MAKI ◽  
ISUKE IMADA
1993 ◽  
Vol 41 (10) ◽  
pp. 1760-1768 ◽  
Author(s):  
Takeshi HASEGAWA ◽  
Tomohiro NIGO ◽  
Takao KAKITA ◽  
Hiromu TOYODA ◽  
Harumasa TOYA ◽  
...  

1995 ◽  
Vol 43 (11) ◽  
pp. 2021-2023 ◽  
Author(s):  
Kohji TERASHIMA ◽  
Hiroshi SHIMAMURA ◽  
Akito KAWASE ◽  
Yuji TANAKA ◽  
Teru TANIMURA ◽  
...  

1988 ◽  
Vol 53 (8) ◽  
pp. 1820-1844 ◽  
Author(s):  
Hana Hulinská ◽  
Zdeněk Polívka ◽  
Jiří Jílek ◽  
Karel Šindelář ◽  
Jiří Holubek ◽  
...  

Reactions of N-cyclohexyl-2-chloroacetamide, N-phenyl-2-chloroacetamide, N-(4-dimethylaminophenyl)-2-chloroacetamide, N-(2-nitrophenyl)-N-phenyl-2-chloroacetamide, its 3-nitrophenyl and 4-nitrophenyl analogues, N-(2-benzylphenyl)-2-chloroacetamide, 5-(chloroacetyl)-dibenz[b,f]azepine, and its 10,11-dihydro derivative with piperazine, 1-methylpiperazine, 2-(1-piperazinyl)ethanol, and 3-(1-piperazinyl)propanol resulted in compounds II, III, V-XV, XVIII, XXI, and XXIII, simple analogues of the antiulcer agent pirenzepine (I). Contributions to the syntheses and characterization of mianserin (XIX), bisnor analogue of imipramine (XXV), and pirenzepine (I) are presented. Two 2-aryl-2-(2-pyridyl)thioacetamides XXXVIII and XL were synthesized via nitriles XXXIX and XLI. Compounds XI (VÚFB-17 104) and XXI (VÚFB-17 113) were found to be rather effective as antiulcer agents and anticholinergics.


1990 ◽  
Vol 38 (11) ◽  
pp. 3035-3041 ◽  
Author(s):  
Ikuo UEDA ◽  
Katsuyuki ISHII ◽  
Katsuo SHINOZAKI ◽  
Masao SEIKI ◽  
Heihachiro ARAI ◽  
...  

ChemInform ◽  
2010 ◽  
Vol 27 (16) ◽  
pp. no-no
Author(s):  
K. TERASHIMA ◽  
H. SHIMAMURA ◽  
A. KAWASE ◽  
Y. TANAKA ◽  
T. TANIMURA ◽  
...  

2013 ◽  
Author(s):  
A. V. Kalueff ◽  
A. M. Stewart ◽  
V. Gjeloshi ◽  
D. Kondaveeti ◽  
N. Neelkantan ◽  
...  
Keyword(s):  

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