scholarly journals Studies on angiotensin converting enzyme inhibitors. II. Syntheses and angiotensin converting enzyme inhibitory activities of carboxyethylcarbamoyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives.

1983 ◽  
Vol 31 (10) ◽  
pp. 3553-3561 ◽  
Author(s):  
KIMIAKI HAYASHI ◽  
KENICHI NUNAMI ◽  
KAZUO SAKAI ◽  
YASUHIKO OZAKI ◽  
JYOJI KATO ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitors ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Inhibitory Activities

Angiotensin converting enzyme inhibitors: 1-glutarylindoline-2-carboxylic acid derivatives

1983 ◽  
Vol 26 (9) ◽  
pp. 1277-1282 ◽  
Author(s):  
Norbert Gruenfeld ◽  
James L. Stanton ◽  
Andrew M. Yuan ◽  
Frank H. Ebetino ◽  
Leslie J. Browne ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitors ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors

Synthesis and evaluation of methyl 2-methoxycarbonyl-3-phenylpropionate derivatives as a new type of angiotensin converting enzyme inhibitors

2006 ◽  
Vol 84 (9) ◽  
pp. 1110-1113 ◽  
Author(s):  
Xiao-hua Cai ◽  
Bing Xie ◽  
Hui Guo
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Ace Inhibitor ◽  
Enzyme Inhibitors ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Key Words Hypertension ◽  
Converting Enzyme Inhibitors ◽  
Control Drug ◽  
New Type ◽  
Inhibitory Activities

Methyl 2-methoxycarbonyl-3-phenylpropionate derivatives were prepared, and their inhibitory activities for angiotensin converting enzyme (ACE) were evaluated. Compounds 5b (IC50 = 0.0039 µmol/L), 5d (IC50 = 0.0027 µmol/L), 5e (IC50 = 0.0021 µmol/L), and5f (IC50 = 0.0052 µmol/L) exhibited more potent ACE inhibitiory activity than the control drug Captopril® (IC50 = 0.0075 µmol/L).Key words: hypertension, 2-methoxycarbonyl-3-phenyl propionate derivative, ACE inhibitor.

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