scholarly journals Preparation and evaluation in vitro and in vivo of polylactic acid microspheres containing dibucaine.

1982 ◽  
Vol 30 (10) ◽  
pp. 3719-3727 ◽  
Author(s):  
NAOKI WAKIYAMA ◽  
KAZUHIKO JUNI ◽  
MASAHIRO NAKANO
Keyword(s):  
Polylactic Acid ◽  
Preparation And Evaluation

scholarly journals Preparation and evaluation in vitro and in vivo of polylactic acid microspheres containing doxorubicin.

1985 ◽  
Vol 33 (1) ◽  
pp. 313-318 ◽  
Author(s):  
KAZUHIKO JUNI ◽  
JUNKO OGATA ◽  
MASAHIRO NAKANO ◽  
TOMOFUMI ICHIHARA ◽  
KATSUTAKA MORI ◽  
...  
Keyword(s):  
Polylactic Acid ◽  
Preparation And Evaluation

scholarly journals Docetaxel-loaded exosomes for targeting non-small cell lung cancer: preparation and evaluation in vitro and in vivo

Drug Delivery ◽  
2021 ◽  
Vol 28 (1) ◽  
pp. 1510-1523
Author(s):  
Ying Wang ◽  
Mimi Guo ◽  
Dingmei Lin ◽  
Dajun Liang ◽  
Ling Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Preparation And Evaluation

scholarly journals Preparation and evaluation of sustained-release azithromycin tablets in vitro and in vivo

2014 ◽  
Vol 9 (3) ◽  
pp. 155-161 ◽  
Author(s):  
Le Sun ◽  
Weixiang Zhang ◽  
Xiaohong Liu ◽  
Jin Sun
Keyword(s):  
Sustained Release ◽  
Preparation And Evaluation

Preparation and Evaluation of Anti-Helicobacter pylori Efficacy of Chitosan Nanoparticles in Vitro and in Vivo

2009 ◽  
Vol 20 (11) ◽  
pp. 1587-1596 ◽  
Author(s):  
Dongqing Luo ◽  
Jianhua Guo ◽  
Fengjie Wang ◽  
Jing Sun ◽  
Guangwu Li ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Chitosan Nanoparticles ◽  
Preparation And Evaluation

scholarly journals Docosahexaenoic Acid-Loaded Polylactic Acid Core-Shell Nanofiber Membranes for Regenerative Medicine after Spinal Cord Injury: In Vitro and In Vivo Study

2020 ◽  
Vol 21 (19) ◽  
pp. 7031
Author(s):  
Zhuo-Hao Liu ◽  
Yin-Cheng Huang ◽  
Chang-Yi Kuo ◽  
Chao-Ying Kuo ◽  
Chieh-Yu Chin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Docosahexaenoic Acid ◽  
Neurite Outgrowth ◽  
Polylactic Acid ◽  
In Vivo Study ◽  
Core Shell ◽  
Cord Injury

Spinal cord injury (SCI) is associated with disability and a drastic decrease in quality of life for affected individuals. Previous studies support the idea that docosahexaenoic acid (DHA)-based pharmacological approach is a promising therapeutic strategy for the management of acute SCI. We postulated that a nanostructured material for controlled delivery of DHA at the lesion site may be well suited for this purpose. Toward this end, we prepare drug-loaded fibrous mats made of core-shell nanofibers by electrospinning, which contained a polylactic acid (PLA) shell for encapsulation of DHA within the core, for delivery of DHA in situ. In vitro study confirmed sustained DHA release from PLA/DHA core-shell nanofiber membrane (CSNM) for up to 36 days, which could significantly increase neurite outgrowth from primary cortical neurons in 3 days. This is supported by the upregulation of brain-derived neurotropic factor (BDNF) and neurotrophin-3 (NT-3) neural marker genes from qRT-PCR analysis. Most importantly, the sustained release of DHA could significantly increase the neurite outgrowth length from cortical neuron cells in 7 days when co-cultured with PLA/DHA CSNM, compared with cells cultured with 3 μM DHA. From in vivo study with a SCI model created in rats, implantation of PLA/DHA CSNM could significantly improve neurological functions revealed by behavior assessment in comparison with the control (no treatment) and the PLA CSNM groups. According to histological analysis, PLA/DHA CSNM also effectively reduced neuron loss and increased serotonergic nerve sprouting. Taken together, the PLA/DHA CSNM may provide a nanostructured drug delivery system for DHA and contribute to neuroprotection and promoting neuroplasticity change following SCI.

Preparation and evaluation of pectin-based colon-specific pulsatile capsule in vitro and in vivo

2012 ◽  
Vol 35 (11) ◽  
pp. 1927-1934 ◽  
Author(s):  
Jing Liu ◽  
Liangke Zhang ◽  
Yuntao Jia ◽  
Wenjing Hu ◽  
Jingqing Zhang ◽  
...  
Keyword(s):  
Preparation And Evaluation

The Preparation and Evaluation of Cepharanthine-Nanostructured Lipid Carriers In Vitro and In Vivo

2017 ◽  
Vol 7 (9) ◽  
pp. 848-857 ◽  
Author(s):  
Qianwen Li ◽  
Tiange Cai ◽  
Yinghong Huang ◽  
Ronghua Zhang ◽  
Susan P. C. Cole ◽  
...  
Keyword(s):  
Nanostructured Lipid Carriers ◽  
Preparation And Evaluation

scholarly journals PREPARATION AND EVALUATION OF PANCHA HARITHAKADI CHURNA FOR DIGESTIVE ACTIVITY

2021 ◽  
Vol 12 (4) ◽  
pp. 19-22
Author(s):  
S. Sarala ◽  
D. Chamundeeswari ◽  
V. Gopal
Keyword(s):  
Heavy Metals ◽  
Particle Size ◽  
Digestive Enzymes ◽  
Fine Powder ◽  
Polyherbal Formulation ◽  
Standard Procedures ◽  
Preparation And Evaluation ◽  
Digestive Activity

Pancha Harithakadi Churna (PHC) is a traditional polyherbal formulation meant for digestion which consists of household ingredients having digestive property. PHC is mainly used for Constipation and Bloating. Churna’s will play an important role in gastro intestinal problems. Churna’s are having greater bioavailability because of smaller particle size. It consists of fine powder (sieve 100 size) of Ginger rhizomes, Fennel fruits, Myrobalan fruits, Senna leaflets and Pink Rock salt in equal proportions (1:1:1:1:1) are mixed well. PHC is formulated by standard procedures and evaluated by physical and analytical methods. Physicochemical standards and heavy metals are found to be within the limits. PHC is found to be free from microbes. The PHC showed pronounced amylolytic activity and moderate lipolytic and proteolytic activity when compared with standard showing its efficacy for treating indigestion. In future we will carry out other digestive enzymes in vitro studies and also to carry out in vivo digestive studies.

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