scholarly journals Effect of fluid volume on gastric emptying and intestinal drug absorption. II. dihydrocodeine and thiopental concentration profiles in plasma after oral administration in different fluid volumes to mice.

1982 ◽  
Vol 30 (5) ◽  
pp. 1892-1895 ◽  
Author(s):  
OSAMI TSUZUKI ◽  
KIMIHIKO KOUNO ◽  
MICHIKO MATSUMOTO ◽  
YASUYOSHI NOGAMI ◽  
TOSHITAKA KOGA
Keyword(s):  
Gastric Emptying ◽  
Oral Administration ◽  
Drug Absorption ◽  
Fluid Volume ◽  
Concentration Profiles ◽  
Intestinal Drug Absorption

scholarly journals Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 272
Author(s):  
Arik Dahan ◽  
Isabel González-Álvarez
Keyword(s):  
Drug Absorption ◽  
Unmet Needs ◽  
Drug Formulation ◽  
Fluid Composition ◽  
Mucosal Cell ◽  
Special Issue ◽  
Junction Resistance ◽  
Intestinal Drug Absorption ◽  
Carrier Mediated Transport ◽  
Mechanistic Basis

The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these segments, and even within the segment, are dependent on many factors, e.g., the surrounding pH, fluid composition, transporters expression, metabolic enzymes activity, tight junction resistance, different morphology along the GIT, variable intestinal mucosal cell differentiation, changes in drug concentration (in cases of carrier-mediated transport), thickness and types of mucus, and resident microflora. Each of these variables, alone or in combination with others, can fundamentally alter the solubility/dissolution, the intestinal permeability, and the overall absorption of various drugs. This is the underlying mechanistic basis of regional-dependent intestinal drug absorption, which has led to many attempts to deliver drugs to specific regions throughout the GIT, aiming to optimize drug absorption, bioavailability, pharmacokinetics, and/or pharmacodynamics. In this Editorial we provide an overview of the Special Issue "Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation". The objective of this Special Issue is to highlight the current progress and to provide an overview of the latest developments in the field of regional-dependent intestinal drug absorption and delivery, as well as pointing out the unmet needs of the field.

A double-peak phenomenon in the pharmacokinetics of veralipride after oral administration: A double-site model for drug absorption

1987 ◽  
Vol 15 (3) ◽  
pp. 225-239 ◽  
Author(s):  
Yves Plusquellec ◽  
G. Campistron ◽  
S. Staveris ◽  
J. Barre ◽  
L. Jung ◽  
...  
Keyword(s):  
Oral Administration ◽  
Drug Absorption ◽  
Double Peak ◽  
Site Model

scholarly journals Robotic screening of intestinal drug absorption

2020 ◽  
Vol 4 (5) ◽  
pp. 485-486
Author(s):  
Abdul W. Basit ◽  
Christine M. Madla ◽  
Francesca K. H. Gavins
Keyword(s):  
Drug Absorption ◽  
Intestinal Drug Absorption

Buprenorphine Delays Drug Absorption and Gastric Emptying in Man

1985 ◽  
Vol 29 (6) ◽  
pp. 599-601 ◽  
Author(s):  
B. Adelhøj ◽  
O. U. Petring ◽  
M. Ibsen ◽  
J. Brynnum ◽  
H. E. Poulsen
Keyword(s):  
Gastric Emptying ◽  
Drug Absorption
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