scholarly journals Characterization of human tissue-specific alkaline phosphatase.

1982 ◽  
Vol 30 (4) ◽  
pp. 1387-1392 ◽  
Author(s):  
KAZUYUKI HIRANO ◽  
YUICHI IIIZUMI ◽  
MAMORU SUGIURA ◽  
JUN MIYAZAKI ◽  
KAZUMASA MIKI ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Human Tissue ◽  
Tissue Specific ◽  
Specific Alkaline Phosphatase

scholarly journals Recombinant Human Tissue Non-Specific Alkaline Phosphatase Successfully Counteracts Lipopolysaccharide Induced Sepsis in Mice

2015 ◽  
pp. 731-738 ◽  
Author(s):  
B. BENDER ◽  
M. BARANYI ◽  
A. KEREKES ◽  
L. BODROGI ◽  
R. BRANDS ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Intravenous Injection ◽  
Human Tissue ◽  
Molecular Mechanisms ◽  
Multiple Organ ◽  
Control Group ◽  
Intestinal Alkaline Phosphatase ◽  
Specific Alkaline Phosphatase ◽  
Transgenic Rabbits ◽  
Rabbit Milk

Sepsis is a life threatening condition that arises when the body's response to an infection injures its own tissues and organs. Sepsis can lead to shock, multiple organ failure and death especially if not recognized early and treated promptly. Molecular mechanisms underlying the systemic inflammatory response syndrome associated with sepsis are still not completely defined and most therapies developed to target the acute inflammatory component of the disease are insufficient. In this study we investigated a possibility of combating sepsis in a mouse model by intravenous treatment with recombinant human tissue non-specific alkaline phosphatase (rhTNAP) derived from transgenic rabbit milk. We induced sepsis in mice by intraperitoneal injection of LPS and three hours later treated experimental group of mice by intravenous injection with rhTNAP derived from transgenic rabbits. Such treatment was proved to be physiologically effective in this model, as administration of recombinant rhTNAP successfully combated the decrease in body temperature and resulted in increased survival of mice (80 % vs. 30 % in a control group). In a control experiment, also the administration of bovine intestinal alkaline phosphatase by intravenous injection proved to be effective in increasing survival of mice treated with LPS. Altogether, present work demonstrates the redeeming effect of the recombinant tissue non-specific AP derived from milk of genetically modified rabbits in combating sepsis induced by LPS.

scholarly journals Clinical Significance of Urinary Human Tissue Non-Specific Alkaline Phosphatase (hTNAP) in Pre-Eclampsia and Eclampsia

1997 ◽  
Vol 34 (4) ◽  
pp. 405-411 ◽  
Author(s):  
Mohamed Shaarawy ◽  
Samira Youssef El Mallah ◽  
Azza Abd El-Monem El-Yamani
Keyword(s):  
Alkaline Phosphatase ◽  
Pregnant Women ◽  
Human Tissue ◽  
Fetal Outcome ◽  
Tubular Damage ◽  
Third Trimester ◽  
Renal Tubular Damage ◽  
Specific Alkaline Phosphatase ◽  
Severity Of The Disease ◽  
Renal Tubular

The aim of this work was to determine the levels of urinary human tissue non-specific alkaline phosphatase (hTNAP) in pre-eclampsia and eclampsia in order to assess renal tubular damage. Urine samples were collected from 26 mild pre-eclamptic, 26 severe pre-eclamptic, 20 eclamptic patients and 20 healthy pregnant women (controls) in their late third trimester. Urinary hTNAP/creatinine (hTNAP/cr) in severe pre-eclampsia and eclampsia were significantly higher than in controls. Urinary hTNAP/cr was increased in 23%, 77% and 90% of cases of mild pre-eclampsia, severe pre-eclampsia and eclampsia, respectively, indicating that the increase correlates with the severity of the disease. Marked elevation or urinary hTNAP/cr was also associated with bad fetal outcome. These results provide additional evidence for renal tubular damage in pre-eclampsia and eclampsia.

Cloning, expression and characterization of human tissue-specific DNA polymerase λ2

2007 ◽  
Vol 50 (4) ◽  
pp. 457-465 ◽  
Author(s):  
Fu Gu ◽  
Chun You ◽  
JianPing Liu ◽  
Ao Chen ◽  
Yao Yu ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Human Tissue ◽  
Tissue Specific

scholarly journals Enhancement of drug delivery to bone: Characterization of human tissue-nonspecific alkaline phosphatase tagged with an acidic oligopeptide

2006 ◽  
Vol 88 (3) ◽  
pp. 244-255 ◽  
Author(s):  
Tatsuo Nishioka ◽  
Shunji Tomatsu ◽  
Monica A. Gutierrez ◽  
Ken-ichi Miyamoto ◽  
Georgeta G. Trandafirescu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Alkaline Phosphatase ◽  
Human Tissue ◽  
Acidic Oligopeptide ◽  
Tissue Nonspecific Alkaline Phosphatase

Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes

Genomics ◽  
1990 ◽  
Vol 8 (3) ◽  
pp. 541-554 ◽  
Author(s):  
Thomas Manes ◽  
Kimberly Glade ◽  
Carol A. Ziomek ◽  
JoséLuis Millán
Keyword(s):  
Alkaline Phosphatase ◽  
Genomic Structure ◽  
Mouse Tissue ◽  
Tissue Specific ◽  
Specific Alkaline Phosphatase
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