scholarly journals Drug-carrier property of albumin microspheres in chemotherapy. IV. Antitumor effect of single-shot or multiple-shot administration of microsphere-entrapped 5-fluorouracil on Ehrlich ascites or solid tumor in mice.

1980 ◽  
Vol 28 (10) ◽  
pp. 3087-3092 ◽  
Author(s):  
YASUNORI MORIMOTO ◽  
MASAYUKI AKIMOTO ◽  
KENJI SUGIBAYASHI ◽  
TANEKAZU NADAI ◽  
YOSHIO KATO
Keyword(s):  
Solid Tumor ◽  
Antitumor Effect ◽  
Drug Carrier ◽  
Single Shot ◽  
Albumin Microspheres ◽  
Ehrlich Ascites ◽  
Multiple Shot

scholarly journals Drug-carrier property of albumin microspheres in chemotherapy. III. Effect of microsphere-entrapped 5-fluorouracil on ehrlich ascites carcinoma in mice.

1979 ◽  
Vol 2 (6) ◽  
pp. 350-355 ◽  
Author(s):  
KENJI SUGIBAYASHI ◽  
MASAYUKI AKIMOTO ◽  
YASUNORI MORIMOTO ◽  
TANEKAZU NADAI ◽  
YOSHIO KATO
Keyword(s):  
Drug Carrier ◽  
Ehrlich Ascites Carcinoma ◽  
Albumin Microspheres ◽  
Ehrlich Ascites

Репрограммированые in vitro на М3 фенотип макрофаги останавливают рост солидной карциномы in vivo

2018 ◽  
pp. 41-46
Author(s):  
А.А. Раецкая ◽  
С.В. Калиш ◽  
С.В. Лямина ◽  
Е.В. Малышева ◽  
О.П. Буданова ◽  
...  
Keyword(s):  
Solid Tumor ◽  
Antitumor Effect ◽  
Tumor Development ◽  
Significant Inhibition ◽  
The Body ◽  
Ehrlich Carcinoma ◽  
Solid Carcinoma ◽  
Ec Cells

Цель исследования. Доказательство гипотезы, что репрограммированные in vitro на М3 фенотип макрофаги при введении в организм будут существенно ограничивать развитие солидной карциномы in vivo . Методика. Рост солидной опухоли инициировали у мышей in vivo путем подкожной инъекции клеток карциномы Эрлиха (КЭ). Инъекцию макрофагов с нативным М0 фенотипом и с репрограммированным M3 фенотипом проводили в область формирования солидной КЭ. Репрограммирование проводили с помощью низких доз сыворотки, блокаторов факторов транскрипции STAT3/6 и SMAD3 и липополисахарида. Использовали две схемы введения макрофагов: раннее и позднее. При раннем введении макрофаги вводили на 1-е, 5-е, 10-е и 15-е сут. после инъекции клеток КЭ путем обкалывания макрофагами с четырех сторон область развития опухоли. При позднем введении, макрофаги вводили на 10-е, 15-е, 20-е и 25-е сут. Через 15 и 30 сут. после введения клеток КЭ солидную опухоль иссекали и измеряли ее объем. Эффект введения макрофагов оценивали качественно по визуальной и пальпаторной характеристикам солидной опухоли и количественно по изменению ее объема по сравнению с группой без введения макрофагов (контроль). Результаты. Установлено, что M3 макрофаги при раннем введении от начала развития опухоли оказывают выраженный антиопухолевый эффект in vivo , который был существенно более выражен, чем при позднем введении макрофагов. Заключение. Установлено, что введение репрограммированных макрофагов M3 ограничивает развитие солидной карциномы в экспериментах in vivo . Противоопухолевый эффект более выражен при раннем введении М3 макрофагов. Обнаруженные в работе факты делают перспективным разработку клинической версии биотехнологии ограничения роста опухоли, путем предварительного программирования антиопухолевого врожденного иммунного ответа «в пробирке». Aim. To verify a hypothesis that macrophages reprogrammed in vitro to the M3 phenotype and injected into the body substantially restrict the development of solid carcinoma in vivo . Methods. Growth of a solid tumor was initiated in mice in vivo with a subcutaneous injection of Ehrlich carcinoma (EC) cells. Macrophages with a native M0 phenotype or reprogrammed towards the M3 phenotype were injected into the region of developing solid EC. Reprogramming was performed using low doses of serum, STAT3/6 and SMAD3 transcription factor blockers, and lipopolysaccharide. Two schemes of macrophage administration were used: early and late. With the early administration, macrophages were injected on days 1, 5, 10, and 15 following the injection of EC cells at four sides of the tumor development area. With the late administration, macrophages were injected on days 10, 15, 20, and 25. At 15 and 30 days after the EC cell injection, the solid tumor was excised and its volume was measured. The effect of macrophage administration was assessed both qualitatively by visual and palpation characteristics of solid tumor and quantitatively by changes in the tumor volume compared with the group without the macrophage treatment. Results. M3 macrophages administered early after the onset of tumor development exerted a pronounced antitumor effect in vivo , which was significantly greater than the antitumor effect of the late administration of M3 macrophages. Conclusion. The observed significant inhibition of in vivo growth of solid carcinoma by M3 macrophages makes promising the development of a clinical version of the biotechnology for restriction of tumor growth by in vitro pre-programming of the antitumor, innate immune response.

scholarly journals Antitumor Effect of Mercury-Hematoporphyrin Complex on Solid-type Ehrlich Ascites Tumor Cells

1960 ◽  
Vol 80 (9) ◽  
pp. 1291-1292
Author(s):  
Mihoko Abe ◽  
Hideo Hirokawa ◽  
Yukito Masamune ◽  
Den'ichi Mizuno
Keyword(s):  
Tumor Cells ◽  
Antitumor Effect ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Ehrlich Ascites ◽  
Solid Type

Antitumor Effect of Snake Venom (Hydrophis spiralis) on Ehrlich Ascites Carcinoma Bearing Mice

2007 ◽  
Vol 3 (4) ◽  
pp. 167-173 ◽  
Author(s):  
R. Karthikeya ◽  
S. Karthigaya ◽  
M. Sri Balasubash ◽  
S. Vijayalaks ◽  
S.T. Somasundar ◽  
...  
Keyword(s):  
Snake Venom ◽  
Antitumor Effect ◽  
Ehrlich Ascites Carcinoma ◽  
Ehrlich Ascites

scholarly journals In vitro and in vivo evaluation of antitumor activity of methanolic extract of Argyreia nervosa leaves on Ehrlich ascites carcinoma

2015 ◽  
Vol 10 (2) ◽  
pp. 399
Author(s):  
Bhawna Sharma ◽  
Isha Dhamija ◽  
Sandeep Kumar ◽  
Hema Chaudhary
Keyword(s):  
Antitumor Activity ◽  
Solid Tumor ◽  
Methanolic Extract ◽  
Ehrlich Ascites Carcinoma ◽  
Ehrlich Ascites ◽  
Wide Range ◽  
Antioxidant Parameters ◽  
Argyreia Nervosa

<p>The herb of importance like <em>Argyreia nervosa</em> has shown wide range of pharmacological activities. Its methanolic extract of <em>A. nervosa</em> has been explored against Ehrlich ascites carcinoma (EAC) induced liquid and solid tumor in mice. Liquid and solid tumors were induced by intraperitoneal and subcutaneous transplantation of EAC cells in Balb/C mice. Significant and dose dependant results are observed when the mice are sacrificed on 15<sup>th</sup> day for estimation of tumor proliferation, hematological, biochemical and hepatic antioxidant parameters. Mean survival time (days) was increased to 36.5 from 20.5 extract treated mice. The extract also showed a decrease (p&lt;0.001) in body weight and percentage reduction in tumor volume respectively when it was evaluated in solid tumor induced mice for a period of 30 days.  From the result it was concluded that the extract has as a potent antitumor activity and that is comparable to 5-fluorouracil.</p><p> </p>

Antitumor Effect of 4-O-Methylglucuronoxylan on Solid Tumor in Mice

1979 ◽  
Vol 43 (5) ◽  
pp. 951-959
Author(s):  
Mieko Hashi ◽  
Takayasu Takeshita
Keyword(s):  
Solid Tumor ◽  
Antitumor Effect

scholarly journals Antitumor Effect of 2-Substituted Benzimidazole against Solid Type of Ehrlich Ascites Tumor

1958 ◽  
Vol 78 (3) ◽  
pp. 242-244 ◽  
Author(s):  
Tomoyoshi Komai ◽  
Hiroko Higurashi ◽  
Mihoko Abe ◽  
Den-ichi Mizuno
Keyword(s):  
Antitumor Effect ◽  
Ehrlich Ascites Tumor ◽  
Ascites Tumor ◽  
Ehrlich Ascites ◽  
Solid Type
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