scholarly journals A new prostaglandin synthon from the 4-oxatricyclo[4.3.0.03,7]non-8-ene system. A total synthesis of (.+-.)-prostaglandin F2.ALPHA..

1979 ◽  
Vol 27 (11) ◽  
pp. 2582-2588 ◽  
Author(s):  
SEIICHI TAKANO ◽  
NOBORU KUBODERA ◽  
HIROMITSU IWATA ◽  
KUNIO OGASAWARA
Keyword(s):  
Total Synthesis ◽  
System A ◽  
Prostaglandin F2 Alpha

Receptor activation induces short-term modulation of arterial contractions: memory in vascular smooth muscle

1995 ◽  
Vol 269 (2) ◽  
pp. C417-C423 ◽  
Author(s):  
P. H. Ratz
Keyword(s):  
Myosin Light Chain ◽  
Receptor Activation ◽  
Inhibitory Effect ◽  
Myosin Light Chain Phosphorylation ◽  
Short Term ◽  
Contraction Coupling ◽  
System A ◽  
Prostaglandin F2 Alpha ◽  
Low Concentrations ◽  
Early Portion

This study examined the hypothesis that arteries retain a memory of receptor activation, resulting in temporary modulation of stimulus-contraction coupling. When pretreated for 30 min with 10(-5) M phenylephrine (PE), histamine, or prostaglandin F2 alpha (PGF2 alpha) and then relaxed fully for 10 min, steady-state increases in stress (S/So) and myosin light-chain phosphorylation (MLC20P/MLC20) produced by KCl in femoral arteries were weaker (0.33-0.57 S/So and 0.29-0.30 MLC20P/MLC20) than control responses (approximately 0.91 S/So and approximately 0.41 MLC20P/MLC20). The inhibitory effect lasted for at least 2 h and was not as strong in tissues pretreated for a 10-fold shorter duration or a 10-fold lower concentration of PE. When pretreated with low concentrations of PE (10(-7) M) and PGF2 alpha (10(-6) M), the early portion of subsequent KCl-induced contractile responses reached levels higher than control responses (0.79-0.86 S/So compared with approximately 0.70 S/So). These data support the hypothesis that receptor activation of arteries not only caused contractions but also stimulated another system, a response modulator that appeared to serve as memory of receptor activation.

ChemInform Abstract: An Asymmetric Route to the Conanine BCDE Ring System. A Formal Total Synthesis of (+)-Conessine.

ChemInform ◽  
2010 ◽  
Vol 28 (8) ◽  
pp. no-no
Author(s):  
M. E. KOPACH ◽  
A. H. FRAY ◽  
A. I. MEYERS
Keyword(s):  
Total Synthesis ◽  
Ring System ◽  
System A
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