scholarly journals Metabolism of piromidic acid, a new antibacterial agent. III. Determination of piromidic acid and its metabolites in blood, urine and bile of rats and humans.

1976 ◽  
Vol 24 (7) ◽  
pp. 1433-1438 ◽  
Author(s):  
YUTAKA SEKINE ◽  
MIE MIYAMOTO ◽  
MASAHISA HASHIMOTO ◽  
KIYOSHI NAKAMURA
Keyword(s):  
Antibacterial Agent ◽  
Piromidic Acid

Metabolism in Rats and Man of Piromidic Acid, a New Antibacterial Agent

Xenobiotica ◽  
1976 ◽  
Vol 6 (3) ◽  
pp. 185-198 ◽  
Author(s):  
Yutaka Sekine ◽  
Mie Miyamoto ◽  
Masahisa Hashimoto ◽  
Kiyoshi Nakamura
Keyword(s):  
Antibacterial Agent ◽  
Piromidic Acid

Use of Transmitted Room-Temperature Phosphorescence to Improve Nalidixic Acid Determination

1998 ◽  
Vol 52 (1) ◽  
pp. 101-105 ◽  
Author(s):  
L. F. Capitán-Vallvey ◽  
F. Ojeda ◽  
M. Del Olmo ◽  
R. Avidad ◽  
A. Navalón ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Nalidixic Acid ◽  
Antibacterial Agent ◽  
Room Temperature ◽  
Acidic Solution ◽  
Sample Holder ◽  
Room Temperature Phosphorescence ◽  
Relative Standard ◽  
Acid Determination

A method for nalidixic acid (NA) determination by transmitted room-temperature phosphorescence is proposed. The antibacterial agent NA in acidic solution shows native fluorescence; when NA is spotted on a filter paper precoated with β-cyclodextrin and lead (II) acetate and dried for 5 min, phosphorescence results. The transmitted phosphorescence was measured directly with the use of a homemade sample holder. The excitation and emission wavelengths were 330 and 417 nm, respectively. The applicable concentration range was between 0.06 and 4.50 μg/mL with a relative standard deviation of 2.8% and a detection limit of 0.02 μg/mL. The method was applied to the determination of NA in human urine and pharmaceuticals, with recoveries from 97.5 to 105.5%.

scholarly journals Metabolism of piromidic acid, a new antibacterial agent. IV. Pharamcokinetics of piromidic acid in rats.

1976 ◽  
Vol 24 (7) ◽  
pp. 1462-1470 ◽  
Author(s):  
YUTAKA SEKINE ◽  
MIE MIYAMOTO ◽  
MASAHISA HASHIMOTO ◽  
KIYOSHI NAKAMURA
Keyword(s):  
Antibacterial Agent ◽  
Piromidic Acid

A New Method for the Determination of Nitrofurantoin in Urine

1965 ◽  
Vol 11 (10) ◽  
pp. 925-931 ◽  
Author(s):  
John D Conklin ◽  
Richard D Hollifield
Keyword(s):  
Urinary Tract ◽  
Human Urine ◽  
Antibacterial Agent ◽  
New Method ◽  
Direct Extraction ◽  
Standard Curve ◽  
Quantitative Procedure

Abstract Nitrofurantoin is presently used as an antibacterial agent for the urinary tract of both man and animals. A new, quantitative procedure for the determination of this drug in urine consists of direct extraction of the nonionized form of the drug by the use of nitromethane, addition of an alkaline reagent to the extract to produce a visible color, and determination of the nitrofurantoin concentration by spectrophotometry. The method has a sensitivity of 5 mg./L., with recoveries of 99-101% and a standard curve that is linear to 100 mg./L. Results indicate that the method measures nitrofurantoin alone, and not its metabolites, in rat, dog, and human urine.

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