scholarly journals Studies on the Reactions of Heterocyclic Compounds. X. 1, 3-Dipolar Cycloaddition Reaction of Isoquinolinium Ylides and Dicyanoacetylene

1973 ◽  
Vol 21 (5) ◽  
pp. 1118-1123 ◽  
Author(s):  
YOSHIRO KOBAYASHI ◽  
ITSUMARO KUMADAKI ◽  
YASUO SEKINE ◽  
TERUO KUTSUMA
Keyword(s):  
Heterocyclic Compounds ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition

Synthesis of New Hexakis-Heterocyclic Compounds and their Use in the Formation and Stabilization of Au and Ag Nanoparticles

2014 ◽  
Vol 976 ◽  
pp. 3-7
Author(s):  
María Isabel Montalvo-Sierra ◽  
Miriam A. Martins Alho ◽  
Ana María Herrera-Gonzalez ◽  
Jesús García-Serrano ◽  
Paola Belem Bocardo-Tovar
Keyword(s):  
Ir Spectroscopy ◽  
Ag Nanoparticles ◽  
Heterocyclic Compounds ◽  
Cyano Group ◽  
Cycloaddition Reaction ◽  
Aldehyde Group ◽  
Dipolar Cycloaddition ◽  
Vis Spectroscopy ◽  
Aldehyde Derivative

The stabilization of nanoparticles in solution is a challenge of major proportions, and avoiding the formation of aggregates and eventual coalescence of particles is directly linked to the conservation of its unique properties. In this work, we reported the synthesis of two hexakis-heterocyclic compounds, containing the tetrazole or 2-amino-1,3,4-thiadiazole group, respectively. The hexa-heterocyclic compounds were used in the synthesis and stabilization of Au and Ag nanoparticles. To obtain these molecules was used phosphonitrilic chloride trimer compound as core, which reacted with phenols properly substituted in theparaposition with either cyano or aldehyde group. The cyano group was successfully converted to the corresponding tetrazole using a 1,3-dipolar cycloaddition reaction with ammonium azide generatedin situ. In the case of aldehyde derivative, it was converted to the corresponding thiosemicarbazone, which was further cyclized using FeCl3. Compounds were characterized by RMN and IR spectroscopy. The UV-Vis spectroscopy was used for nanoparticles analysis.

1,3-Dipolar cycloaddition of nitrones: synthesis of multisubstituted, diverse range of heterocyclic compounds

2021 ◽  
Author(s):  
Seema Thakur ◽  
Arunima Das ◽  
Tapas Das
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Cycloaddition Reaction ◽  
Biologically Active ◽  
Dipolar Cycloaddition ◽  
Diverse Range

The 1,3-dipolar cycloaddition reaction of nitrone is one of the most important methods for the synthesis of different sizes of heterocycles which have enormous applications in natural products, biologically active molecules and pharmaceuticals.

scholarly journals HUISGEN AND HIS ADVENTURES IN A PLAYGROUND OF MECHANISMS AND NOVEL REACTIONS

Química Nova ◽  
2020 ◽  
Author(s):  
Daniel Gonzaga ◽  
Luana Forezi ◽  
Carolina Lima ◽  
Patricia Ferreira ◽  
Fernando Silva ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Cycloaddition Reaction ◽  
Professor Emeritus ◽  
Dipolar Cycloaddition ◽  
Cycloaddition Reactions ◽  
University Of Munich ◽  
The University

The death of professor Rolf Huisgen (1920-2020) was announced on March 26th 2020, in the midst of the COVID-19 pandemic. Professor Huisgen was professor emeritus at the University of Munich in Germany, and studied in detail the mechanism of the 1,3-dipolar cycloaddition reaction, significantly expanding its scope. Even though he did not discover this reaction, it was through his studies that it became important in organic synthesis. Indeed, in honor of his work, the reaction became known as Huisgen’s cycloaddition and it has been consolidated as a useful method for the preparation of five-membered heterocyclic compounds. Considering these facts, in this review we provide an overview on the applications of 1,3-dipolar cycloaddition reactions, starting with the seminal examples in the field and further discussing the most recent applications.

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