scholarly journals Pyrimidine Derivatives and Related Compounds. XIII. The Synthesis of N-Substituted Pyrazolo [3.4-d] pyrimidines from Pyrazole Derivatives

1972 ◽  
Vol 20 (2) ◽  
pp. 391-398 ◽  
Author(s):  
SHIGEO SENDA ◽  
KOSAKU IROTA ◽  
GUANG-NAN YANG
Keyword(s):  
Pyrazole Derivatives ◽  
Pyrimidine Derivatives ◽  
Related Compounds

scholarly journals An efficient synthesis of pyrido[2,3-d]pyrimidine derivatives and related compounds under ultrasound irradiation without catalyst

2008 ◽  
Vol 15 (3) ◽  
pp. 217-221 ◽  
Author(s):  
Shujiang Tu ◽  
Longji Cao ◽  
Yan Zhang ◽  
Qingqing Shao ◽  
Dianxiang Zhou ◽  
...  
Keyword(s):  
Ultrasound Irradiation ◽  
Efficient Synthesis ◽  
Pyrimidine Derivatives ◽  
Related Compounds

Synthesis of Some Pyrazolo [Diazepine, Pyrazole, Isoxazole and Pyrimidine] Derivatives and Related Compounds

1980 ◽  
Vol 35 (10) ◽  
pp. 1313-1316 ◽  
Author(s):  
El-Sayed Afsah ◽  
Fathy A. Amer ◽  
Momdouh Soafan
Keyword(s):  
Acetic Anhydride ◽  
Acid Derivative ◽  
Pyrimidine Derivatives ◽  
Related Compounds

Abstract 4-Arylidene-3-methyl-1-phenyl-2-pyrazolin-5-ones (1a-d) undergoes condensation with diethylmalonate, p-nitroacetophenone and/or 3-acetyl-pyridine under Michael condition to give compounds 2, 3 and 4, respectively. Treatment of 3 and 4 with hydrazine afforded the pyrazolodiazepines 7 and 8, respectively. Interaction of la with diethyl phenyl-malonate gave the Michael product 9, which undergoes hydrolysis, decarboxylation and cyclisation to give the indanone derivative (11). Condensation of 1c with hydrazine, hydroxylamine and urea gives compounds 12, 13 and 14, respectively. Cyclisation of the Michael compound 15 gives the benzopyranopyrazole (14). When 1c was subjected to Riemer-Tiemann reaction gives compounds 17 and 18. Acetic anhydride treatment of 18 gives the acetyl cresotic acid derivative (19).

Synthesis of amino acids and related compounds. 42. A novel transformation of imidazolines into 2,4,6-trisubstituted pyrimidine derivatives

1993 ◽  
Vol 58 (23) ◽  
pp. 6354-6359 ◽  
Author(s):  
Masahiko Seki ◽  
Hitoshi Kubota ◽  
Kazuo Matsumoto ◽  
Akio Kinumaki ◽  
Tadamasa Date ◽  
...  
Keyword(s):  
Amino Acids ◽  
Pyrimidine Derivatives ◽  
Related Compounds

Pyrimidine Derivatives and Related Compounds, V Synthesis of Some Isoxazolo [2,3-a] pyrimidines. A New Ring System

1977 ◽  
Vol 32 (3) ◽  
pp. 311-314 ◽  
Author(s):  
Mohamed Hilmy Elnagdi ◽  
Ezzat Mohamed Kandeel ◽  
Kamal Usef Sadek
Keyword(s):  
Acetic Acid ◽  
Hydrochloric Acid ◽  
Ethyl Acetoacetate ◽  
Pyrimidine Derivative ◽  
Ring System ◽  
The Other ◽  
Acid Mixture ◽  
Pyrimidine Derivatives ◽  
Benzoyl Isothiocyanates ◽  
Related Compounds

3-Amino-5-phenyl-4-phenylazoisoxazole (1) reacts with ethyl acetoacetate to yield the corresponding ethyl isoxazolylaminocrotonate derivative (2) which could be thermally cyclized into the isoxazolopyrimidine derivative (4). On the other hand, condensation of 1 with ethoxymethylenemalononitrile has resulted in the formation of the aminoethylene derivative (5).Compound 1 reacted with acrylonitrile to yield the isoxazolo[2,3-a]pyrimidine derivative (6). The latter was converted into the corresponding exo derivative (8) by the action of acetic acid-hydrochloric acid mixture.Compound 1 also reacted with methoxycarbonyl-, ethoxycarbomyl- and benzoyl isothiocyanates to yield the isoxazolylthioureas (10a, b) and (11), respectively. The reaction of 2 with acetic acid-hydrochloric acid and with phenylhydrazine is reported.

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