scholarly journals Stimulating Effect of Panax ginseng Extract on RNA Polymerase Activity in Rat Liver Nuclei

1971 ◽  
Vol 19 (8) ◽  
pp. 1656-1663 ◽  
Author(s):  
SUSUMU HIAI ◽  
HIKOKICHI OURA ◽  
KINJI TSUKADA ◽  
YOSHIKATSU HIRAI
Keyword(s):  
Rna Polymerase ◽  
Panax Ginseng ◽  
Rat Liver ◽  
Polymerase Activity ◽  
Ginseng Extract ◽  
Rat Liver Nuclei ◽  
Rna Polymerase Activity ◽  
Liver Nuclei

scholarly journals The effects of copper and other ions on the ribonucleic acid polymerase activity of isolated rat liver nuclei

1969 ◽  
Vol 111 (1) ◽  
pp. 115-119 ◽  
Author(s):  
F. Novello ◽  
F. Stirpe
Keyword(s):  
Rna Polymerase ◽  
Ammonium Sulphate ◽  
Rat Liver ◽  
Ribonucleic Acid ◽  
Polymerase Activity ◽  
Isolated Rat Liver ◽  
Rat Liver Nuclei ◽  
Liver Nuclei ◽  
Isolated Liver ◽  
Isolated Rat

1. The effects of various ions on the Mg2+- and Mn2+/ammonium sulphate-activated RNA polymerase activities of isolated liver nuclei were studied. 2. The Mg2+-activated RNA polymerase reaction was inhibited by more than 60% by Cd2+, SeO32−, Be2+, Cu2+, Co2+, Ca2+ and La3+, all at 1mm concentrations. 3. The Mn2+/ammonium sulphate-activated RNA polymerase reaction was strongly inhibited by Hg2+, Cd2+, Cu2+ and Ag+. The effect of Hg2+, Cd2+ and Ag+ was relieved by cysteine or mercaptoethanol. 4. Inhibition by Cu2+ was not affected by addition of DNA, and was relieved only partially by EDTA or histidine. 5. No changes of RNA polymerase activities were observed in nuclei isolated from the liver of rats treated with copper albuminate.

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