scholarly journals Bromoacylpolystyrene, a New Type of Polymer Support for Solid Phase Peptide Synthesis

1969 ◽  
Vol 17 (2) ◽  
pp. 411-412 ◽  
Author(s):  
TOMISHIGE MIZOGUCHI ◽  
KEISUKE SHIGEZANE ◽  
NORIO TAKAMURA
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Polymer Support ◽  
New Type

A novel core-shell type polymer support for solid-phase peptide synthesis

2000 ◽  
Vol 41 (39) ◽  
pp. 7481-7485 ◽  
Author(s):  
Jin Ku Cho ◽  
Byeong-Deog Park ◽  
Yoon-Sik Lee
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Polymer Support ◽  
Core Shell ◽  
Shell Type

SUBPOL:  A Novel Sucrose-Based Polymer Support for Solid-Phase Peptide Synthesis and Affinity Chromatography Applications

2003 ◽  
Vol 125 (44) ◽  
pp. 13415-13426 ◽  
Author(s):  
Alexander Poschalko ◽  
Thomas Rohr ◽  
Heinrich Gruber ◽  
Alberto Bianco ◽  
Gilles Guichard ◽  
...  
Keyword(s):  
Affinity Chromatography ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Polymer Support

scholarly journals Solid Phase Peptide Synthesis employing Haloacylpolystyrene as a Polymer Support

1970 ◽  
Vol 18 (7) ◽  
pp. 1465-1474 ◽  
Author(s):  
TOMISHIGE MIZOGUCHI ◽  
KEISUKE SHIGEZANE ◽  
NORIO TAKAMURA
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Polymer Support

scholarly journals Solid Phase Peptide Synthesis by Four Component Condensation: Peptide Formation on an Isocyano Polymer Support

1981 ◽  
Vol 36 (9) ◽  
pp. 1202-1203 ◽  
Author(s):  
Reza Arshady ◽  
Ivar Ugi
Keyword(s):  
Amino Acids ◽  
Peptide Synthesis ◽  
Trifluoroacetic Acid ◽  
Room Temperature ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Polymer Support ◽  
Small Peptides ◽  
Peptide Formation

Abstract Coupling of various protected amino acids or small peptides on an isocyano polymer and in the presence of 1 -methyl-3-formylindole demonstrates the feasibility of peptide formation by four component condensation on a polymer support, and the final peptide is detached from the resin by 50% trifluoroacetic acid in aceto-nitrile at room temperature.

The Boc/Solid Phase Synthesis of Glu-Abu(P)-Leu

1992 ◽  
Vol 45 (10) ◽  
pp. 1765 ◽  
Author(s):  
JW Perich ◽  
EC Reynolds
Keyword(s):  
Amino Acids ◽  
Peptide Synthesis ◽  
Trifluoroacetic Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Hydrogen Bromide ◽  
Solid Phase Peptide Synthesis ◽  
Polymer Support ◽  
Methyl Groups ◽  
Phase Synthesis

The synthesis of the 4-phosphono-2-aminobutanoyl-containing tripeptide , H- Glu -Abu(P)- Leu-OH.CF3C02H was accomplished by the use of Boc-Abu(PO3Me2)-OH in Boc /solid phase peptide synthesis. Peptide synthesis was performed by using Boc-Leu-polystyrene as the polymer support with the peptide assembled by the use of 1H-benzotriazol-1-yloxytris(pyrro1idin-1-yl) phosphonium hexafluorophosphate ( PyBOPR ) for the coupling of Boc amino acids and 50% CF3C02H/CH2C12 for cleavage of the Boc group from the Boc -peptide after each coupling cycle. The protected peptide was cleaved from the polymer support by hydrogen bromide in trifluoroacetic acid and final cleavage of the methyl groups from Glu-Abu(PO2Me2)-Leu was effected by silylitic treatment with 30% bromotrimethylsilane in acetonitrile.

A Strategy for Thioamide Incorporation During Fmoc Solid-Phase Peptide Synthesis with Robust Stereochemical Integrity

2019 ◽  
Author(s):  
luis camacho III ◽  
Bryan J. Lampkin ◽  
Brett VanVeller
Keyword(s):  
Amino Acid ◽  
Functional Groups ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Side Chains ◽  
Amino Acid Side Chains ◽  
Peptide Elongation

We describe a method to protect the sensitive stereochemistry of the thioamide—in analogy to the protection of the functional groups of amino acid side chains—in order to preserve the thioamide moiety during peptide elongation.<br>

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