scholarly journals Studies on Absorption and Excretion of Drugs. IX. Relation between Chemical Structure and Absorption Rate. (1). Effects of the Number and the Position of OH-Groups on the Intestinal Absorption Rate of Benzoyl Derivatives

1968 ◽  
Vol 16 (3) ◽  
pp. 389-395 ◽  
Author(s):  
HISASHI NOGAMI ◽  
MANABU HANANO ◽  
HIDEO YAMADA
Keyword(s):  
Intestinal Absorption ◽  
Chemical Structure ◽  
Absorption Rate ◽  
Oh Groups

Intestinal absorption of coprostanol (coprosterol) in the rat

1960 ◽  
Vol 199 (6) ◽  
pp. 1008-1010 ◽  
Author(s):  
C.S. Narayana Setty ◽  
A. C. Ivy
Keyword(s):  
Oleic Acid ◽  
Intestinal Absorption ◽  
Chemical Structure ◽  
Control Period ◽  
Chair Conformation ◽  
Color Reaction ◽  
Salt Mixture ◽  
Streptomycin Sulfate

A basal sterol-free diet consisting of casein, 18%; dextrin, 57%; oleic acid, 9%; U.S.P. salt mixture, 2%; yeast, 5%; and cellulose, 9%; along with 1% sulfasuxidine and 0.2% streptomycin sulfate was fed to eight rats during a control period of 12 days, the feces being collected under alcohol the last 4 days and assayed for digitonide sterol. The experiment was repeated with the addition of 28 mg of coprostanol to the diet. It was found that from 41 to 61% (average 48%) of the coprostanol was absorbed. The relation of chemical structure to the absorbability of cholesterol derivatives is discussed with the finding that all absorbable cholesterol derivatives have the ‘chair’ conformation, but are not alike in digitonide formation and Liebermann-Burchard color reaction.

The increased intestinal absorption rate is responsible for the reduced hepatic first-pass extraction of propranolol in rats with cisplatin-induced renal dysfunction

2003 ◽  
Vol 55 (4) ◽  
pp. 479-486 ◽  
Author(s):  
Hiromi Okabe ◽  
Akiko Mizukami ◽  
Masato Taguchi ◽  
Tetsuya Aiba ◽  
Masato Yasuhara ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Intestinal Absorption ◽  
Absorption Rate ◽  
First Pass

scholarly journals Absorption of inorganic, trivalent and hexavalent chromium following oral and intrajejunal doses in rats

2001 ◽  
Vol 49 (2) ◽  
pp. 203-209 ◽  
Author(s):  
Hedvig Fébel ◽  
B. Szegedi ◽  
Szilvia Huszár
Keyword(s):  
Intestinal Absorption ◽  
Hexavalent Chromium ◽  
Absorption Rate ◽  
Water Soluble ◽  
Chromic Oxide ◽  
Sodium Chromate ◽  
Rat Intestine ◽  
Indicator Method ◽  
Lower Blood ◽  
Chromium Compounds

The intestinal absorption of trivalent and hexavalent chromium (Cr) given orally (experiment I) or infused in the intestine (experiment II) was investigated in rats. The nonabsorbable form of chromium (51Cr2O3) and water-soluble and more absorbable Na251CrO4 (the hexavalent form of Cr) were compared. Total retention of chromium given orally ranged around 15 percent of the dose, regardless of the chromium compounds applied. The absorption rate of chromic oxide, which is considered a nonabsorbable compound, was 14.4 as a percentage of chromium intake. This result indicates that some loss of chromium has to be taken into account in metabolic trials made by the indicator method. In isolated rat intestine, from the injected Cr 2.5% of chromic oxide and 43.2% of sodium chromate were absorbed during an hour (experiment II). The absorbed chromium was transferred to the liver where the liver tissue retained 10.9% of chromic oxide and 51.1% of sodium chromate. Radioactivity of v. cava caudalis following intestinal injection of Na2CrO4 was thirtyfold greater than after Na2CrO4 dosing. This phenomenon can be explained by the lower blood clearance of chromate. Different absorption rate of chromate depending on the route of administration could be due to the fact that the hexavalent form given orally was reduced to Cr3+ in the acidic environment of the stomach. When Na2CrO4 was infused directly in the intestine of rats, such reduction could not occur. This means that the acidic gastric juice might play a role in inhibiting the intestinal absorption of Na2CrO4 when this compound is given orally.

The ex-vivo intestinal absorption rate of uranium is a two-phase function of supply

2014 ◽  
Vol 69 (2) ◽  
pp. 256-262 ◽  
Author(s):  
Rainer Konietzka ◽  
Rita Heinze ◽  
Margarete Seiwert ◽  
Hermann H. Dieter
Keyword(s):  
Intestinal Absorption ◽  
Phase Function ◽  
Absorption Rate ◽  
Ex Vivo ◽  
Two Phase

Total intestinal absorption of glucose and l-methionine in broilers infected with Eimeria acervulina, E. mivati, E. maxima or E. brunetti

Parasitology ◽  
1980 ◽  
Vol 80 (3) ◽  
pp. 555-569 ◽  
Author(s):  
M. D. Ruff ◽  
G. C. Wilkins
Keyword(s):  
Intestinal Absorption ◽  
Broiler Chickens ◽  
Absorption Rate ◽  
Glucose Absorption ◽  
Equal Weight ◽  
Post Inoculation ◽  
Eimeria Acervulina ◽  
Total Potential ◽  
Unit Of Measurement

SummaryThe in vitro absorption of glucose and l-methionine in the intestine of broiler chickens was measured 7, 14 and 21 days post-inoculation (p.i.) with sporulated oocysts of Eimeria acervulina, E. mivati, E. maxima or E. brunetti. The small intestine of each bird was divided into 8 regions of equal length and absorption was measured on 3 tissue disks of equal size from each region. The absorption rate of each substrate with each coccidial species was measured based on (1) an equal area from each region, (2) an equal weight from each region, (3) the total absorption in each region and (4) the total potential absorption in the intestine. Comparisons of absorption rate of equal areas in each intestinal region demonstrated that infected birds at 7 days p.i. absorbed significantly less substrate per unit area in the regions of maximum infection than uninfected controls. Malabsorption was less apparent when the weight of the region was used as the unit of measurement. Compensatory absorption was seen in some uninfected regions with E. acervulina. The total potential intestinal absorption at 7 days p.i. was reduced with E. mivati, E. maxima and E. brunetti but not with E. acervulina. At 14 days p.i., total l-methionine and glucose absorption in some regions of the intestine was significantly increased with E. acervulina but not with E. mivati, E. maxima or E. brunetti. No absorption differences were seen at 21 days p.i. with any species.

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